Iproton-pump inhibitors inokunyusa umngcipheko weentlobo ezithile.
Kwimbali yamayeza, ezimbalwa iziyobisi ziye zasebenza ngokukhawuleza ekunciphiseni ubuhlungu njengeproton-pump inhibitors (PPIs) , okanye imithi efana ne-omeprazole (i-generic), i-Prevacid ne-Nexium.
Iproton-pump inhibitors inceda izigidi zabantu baseMelika zifumane ukukhulula kwi- reflux ye-gastroesophageal disease (GERD). Isifo se-reflux se-Gastroesophageal senziwa ngokuqhelekileyo xa isisu sityhilela into yaso e-acidic ebuyela kwisitopu, okanye ipayipi yokutya, ngaloo ndlela kudala ukucaphukisa okanye ukuguquka.
(Ubuncinci bemiba yabantu abanamava okukhankanya kwi-GERD eyesibili ukuya kwixesha elifutshane elingaphantsi kwe-sphincter ukuphumula okanye i- TLESR .)
Kwiyona nto ininzi, iiPPIs zikhuselekile ngokwenene. Nangona kunjalo, bekukho ukugubungela phakathi kwamalungu ommandla wezonyango ukuba i-PPIs ingakhokelela ekuphukeni kwethambo phakathi kwabantu abadala (ikakhulukazi abasetyhini abasebekhulile abasengozini enkulu ye- osteopenia okanye i-osteoporosis).
Ukongezelela, kukho iinkxalabo ezithile ukuba i-PPIs inokuthi igalele ngandlela-thile umngcipheko wokuqhaqha , okubangela iindleko ezinkulu, ukukhubazeka, ukugula kunye nokufa okuhambisanayo.
Ixhaphake kangakanani ukusebenzisa i-PPIs?
Iproton-pump inhibitors ngokwenene inciphisa inani le-asidi elifihliweyo ngesisu. Ngokuphawulekayo, iiPPIs zibhetele ekunciphiseni ukugcinwa kwe-acid esiswini kunokuba zi-block block ze-H2, okanye i-histamine-blocking medication, njenge-Zantac okanye i-cimetidine.
E-United States ngo-2009, malunga nezigidi ezili-120 zeemfuno ze-PPI zabhalwa.
Ukongezelela, loo nyaka ukuthengiswa kwee-PPIs kuye kwaba ngu-13.5 billion.
Amaphesenti angama-40 abantu abadala baseMelika bafumana iimpawu ze-GERD nyanga zonke, kwaye abantu abaninzi bahlala kwixesha elide lokwelapha i-PPI ukuphelisa intlungu.
I-PPIs ingaba negalelo njani kwiNgcipheko yeThambo?
Enye indlela ecacileyo yokuba i-PPIs inokubangela ukuba ingozi yokuphulwa kwethambo ibandakanya ukunciphisa i-calcium ngesondlo sesisu.
Ukulawulwa kwezidakamizwa ezingapheliyo kunokuthi kungonakalise ukutyalwa kwe-calcium, efunekayo ukuze kusetyenziswe amathambo, ukugcinwa kunye nokulungiswa.
Nazi ezinye iingcamango ezichaza indlela i-PPIs inokunyusa ngayo umngcipheko wesifo seethambo.
- I-PPI inyuse ukukhululwa kwe-gastrin, enye ihomoni yesisu, ephazamisa umsebenzi we-thyroid. I-thyroid ifihla i-calcitonin kunye ne- hormone ye-parathyroid (PTH) , elawula iqondo le-calcium kwigazi kunye ne-bone metabolism.
- I-PPIs inokuchaphazela ngqo i-osteoclasts kunye ne-osteoblasts, okanye iiseli ezidibanayo kwaye zakha ithambo, ngokulandelanayo.
- Abantu abahlala bethatha ii-PPIs banokuthi bafumane ezinye iimeko kunye neentlobo ezingabangela ukulahleka kwe-calcium kunye nokuphuka kwethambo, njengokusetyenziswa kwe-thiazide diuretics okanye esinye isifo sesisu. Ukongezelela, aba bantu banokuphuza utywala obuninzi, okwenza utshintsho lwama-calcium kunye ne-bone metabolism.
- Abantu abahlala bethatha ii-PPIs banokulungisa izidlo zabo ukuze banciphise iimpawu ze-GERD ngale ndlela ngandlela-thile ukunciphisa i-calcium absorption.
Oko Uphando lucebisa
Kwangexesha elide, uphando oludibanisa ukusetyenziswa kwexesha elide lwePPI kunye neentlobo zethambo zaxutyaniswa. Kwaye kwaze kwaba ngo-2010 ukuba sibone isifundo sokuqala esilungileyo sihlolisisa ikhonkco phakathi kwezi zimbini.
Ukusebenzisa idatha esuka kwi-Women's Health Initiative, uvavanyo lwezempilo lukazwelonke oluhlola abafazi abangama-161,808 abavela kwimimandla eyahlukeneyo abaneminyaka engama-50 ukuya ku-79 ubudala, abaphandi bavelisa isilingo esilindele ukuba sihlolisise imibutho phakathi kwexesha elide lokusetyenziswa kwePPI, ingozi yokuphulukana kwethambo kunye ne-bone mineral power (esinye isalathisi impilo yethambo).
Ngokutsho kweziphumo zolu cwaningo, ukusetyenziswa kwexesha elide le-PPI kudibene nomngcipheko okhulayo we-clinical spine, iphambili, isandla kunye neziqhekeza ezipheleleyo. Nangona kunjalo, ukusetyenziswa kwexesha elide le-PPI kwakungekho nxu lumngcipheko lweemfucu ze-hip okanye ukuhla kwe-bone mineral.
Uluphando Luni Kuwe?
Ukuba usukhulile kwaye ugqirha wakho uye wanikezela ukuba unyango lwe-PPI lwexesha elide lokufumana ukukhutshwa kwi-GERD, kufuneka uqhubeke nokuthatha le mayeza kwaye udibane nodokotela wakho rhoqo.
Ukukhathazeka okukodwa malunga neePPs ezikhokelela ekuphukeni kwethambo akufanele kukuyeke ukufumana ukukhululeka kwesisu.
Nangona kunjalo, ugqirha wakho kufuneka ahlole ngenyameko ukuba ngaba ufuna i-PPI kwaye kwaye, ukuba kunjalo, ijolise ukunika umlinganiselo omncinci wokulinganisa. Ngaphezulu, ngelixa uhlala kwi-PPIs, kufuneka uqiniseke ukuba udle ukutya okunokulinganisela okugcwele i-calcium eyaneleyo. Ugqirha wakho unokufuna ukumisela i-calcium supplement.
Ukuba uhlala uthabatha ii-PPI zokulawula ukuguquka kwenhliziyo kodwa ungakaze ubonwe ugqirha kule ngxaki, yinto efanelekileyo yokwenza i-aphoyintimenti kwaye uvavanywe.
Imithombo:
"Ukusetyenziswa kwe-Proton Pump Inhibitor, ukuHlaba kwe-Hip, kunye noTshintsho kwi-Bone Mineral Density In Women's Postmenopausal: Iziphumo ezivela kwi-Women's Health Initiative" nge-SL Grey kunye nabalobi ababambisene nabo abapapashwe kwi- Archives of Internal Medicine ngo-2010.
"Umbutho wexesha elide leproton Pump Inhibitor Therapy kunye ne-Bone Fractures kunye neempembelelo kwi-Absorption of Calcium, i-Vitamin B12, i-Iron, ne-Magnesium" ngo-T Ito no-RT Jensen kwiiNgxelo ze-Gastroenterology zangoku ngo-2010.