Izifo zesibindi ngenxa yeeNkcazo kunye neMiphumo yeeNkcazo kwiSifo seBindi
Ngaba unako ukusela utywala kunye ne-Lipitor okanye enye imithi ye-statin? Ukuba ifakwe ipakethe ibhekisela "ekumodareyithweni" ekudleni kotywala, kuthini oko kuthetha ntoni? Iyintoni umphumo weemimiselo kwisibindi? Ukusuka kwinqanaba elichaseneyo, siyazi ntoni ngesiphumo sama-statins kwisifo sesibindi?
Izinzuzo ze-Statin Drugs ezifana ne-Lipitor (Atorvastatin)
Izitatimende zenze umehluko omkhulu malunga nesifo senhliziyo.
Bazinzisa i-coronary artery plaques ezingakhokelela ekuhlaselweni kwentliziyo, eyona nto ibangela ukufa ku-US ngaphambi komhlaza. Banciphisa ubungakanani bala macwecwe . Banciphisa ukuvuvukala . Kubonakala ngathi banceda ngegazi elingavamile. Banciphisa ingozi ye-Alzheimer's disease. Banciphisa ithuba lokuba uya kuba ne-cataract. Baya kuphucula uphulo lomhlaza womphunga , eyona nto ibangela ukuba ukufa kwabantu abachaphazeleka ngumhlaza kumadoda nabasetyhini. Ngoko umbuzo malunga nokuba ufuna ukudibanisa la mayeza kunye notywala kufuneka uphendule ngokucophelela.
I-Alcohol Warning with Lipitor (Statins)
Ngokwe- Lipitor (i-atorvastatin) esemthethweni ipakethi-evunywe yi-US Food and Drug Administration (FDA) -Liphathi "kufuneka isetyenziswe ngokugulisa kwizigulane ezitya kakhulu ubuninzi botywala kunye / okanye zineembali zesifo sesibindi." Ngelishwa , akukho "isisemthethweni" inkcazo yoluphi ubungakanani bokusela kotywala.
Ukuqonda ukuba kutheni ukuba nayiphi na inkunkuma yotywala ingaba yingxaki kunye ne-Lipitor okanye nayiphina imimiselo, makhe sijonge indlela amayeza angasichaphazela ngayo isibindi, nokuba utywala bunokunyusa njani umphumo.
Impembelelo yeeNkcazo kwiNgqumbo
Akuqhelekanga ukuba uvavanyo lwesibindi olungavamile xa uthatha i-statins, kodwa kubalulekile ukuqonda oko kuphelile.
Kukho iindlela ezahlukeneyo zokuchaza indlela i-statins echaphazela ngayo isibindi, ngoko makhe sibone ukutshintsha kwimivavanyo yesibindi yedwa (akukho zibonakaliso,) izifo zesibindi zesifo (izibonakaliso) ezihambelana nokusetyenziswa kwesimo somzimba, isifo esiqinileyo sesibindi, kunye nendlela i-statins inganciphisa ngayo Ukufa kubantu abathile sele benesifo sesibindi.
Iimvumi ze-Enzymes kunye neeNkcazo ezifana neLipitor
Iingcebiso zangoku zihlolwe ukuba uvavanyo lweesibindi luhlolwe ngaphambi kokuqala i-Lipitor, kwaye emva kweeveki ezili-12. Ukubekwa iliso kufuneka kuqhubeke ngokukhawuleza kwithuba lexesha umntu esela mayeza. Oko kwathiwa, ixesha elide ukuba i-Lipitor ibekwe kwiimarike, amaninzi amaninzi angamayeza ayenayo ekulandeleni le mvavanyo ngokuhamba kwesikhathi.
Izifundo ziye zafumanisa ukuba abanye abantu abasebenzisa i-Lipitor banokuphakama kwe- enzyme ye- aspartate i-aminotransferase (AST) kunye ne-alanine aminotransferase (ALT.) Ukwanda (ukuya kwexesha eliqhelekileyo kathathu) kulezi zixabiso kubakho malunga neepesenti ezintathu zabantu. Oko sikufundile ngexesha elide, nangona kunjalo, kukuba ininzi yexesha ezi ziphakamileyo zisesigxina kwaye ayisoloko yingozi.
Ukususela ekumodareyithweni ukuya kwinqanaba eliphezulu lokusela utywala kunokunyusa ukwenziwa kovavanyo lweesibindi, ukudibanisa ukusela kakhulu kunye nemimiselo kuza kwandisa amathuba okungaqhelekanga.
Ukulimala kwesibindi kunye neengxelo
Ukulimala kwesibindi kwenzakalo okwaneleyo kubangele iimpawu kunokuba zivivinye nje kuphela zolu hlobo lwezilingo zentsholongwane-akuqhelekanga ngama-statins, ngokungafani nokuphakama kweenzyme zesibindi esisodwa esizibonile.
Ngokuqinisekileyo, ukulimala kwesibindi kunokwenzeka. Kukho ubuncinane iingxelo ezingama-50 zesibindi sesibindi kubantu abathatha izitembu eziye zaholela ekufeni okanye isidingo sokufakelwa kwesibindi. Ukujonga le manani, nangona kunjalo kubalulekile ukuba uqaphele ukuba ngeli xesha i-Lipitor ibe yimbosi enye echanekileyo kwiziyobisi emhlabeni jikelele. (Xa kuthelekiswa, kucatshangelwa ukuba abantu abayi-15 000 bafa ngamnye ngonyaka ukusuka kwintsholongwane yesisu esisuka ku-Advil.) Ukulimala kakhulu kwesibindi kunokwenzeka kwiimimiselo, kodwa oku akunqabile.
Xa uthetha ngefuthe lotywala kwisifo sesibindi esihambelana nama-statins, kubalulekile ukuba uqaphele ukuba ukulimala kwesibindi esingaqhelekanga kungekhona ngenxa yempembelelo yokulimala. Kunoko, isilwanyana esibangela isifo sesibindi ngokuqhelekileyo sisigxina se-autoimmune, apho izidakamizwa zikhuthaza abanye abantu ukuba benze izilwanyana eziza kuhlasela izicubu zabo zesibindi. Oku kuthethwa ngokuthi "idiosyncratic" yokusabela, into engacaciswanga kakuhle kwaye ayikwazi ukuqikelelwa.
Olunye uhlangothi lwe-Equation - Iitatimende ezinokuthi zibe Ncedisayo ngeSifo seSibindi
Kungenokuba yinto eqinisekisayo ukuva ukuba, nangona iinconywa zokubeka iliso kwiimvavanyo zesibindi, kunye neengozi ezingaqhelekanga zokulimala kwesibindi, izitembu zinokuba luncedo kwabanye abantu abanezifo zesibindi.
Kwisifundo esithile ekhangele abantu abanezifo ezinobisi obunxilisayo , ukusetyenziswa kwemimiselo yesigxina kubeka ingozi yokufa kwi- cirrhosis yotywala. Isiphelo sophando lwango-2017 kukuba i-statins esetyenziselwa abantu abanezifo ezingasigxina zingaphinda zinciphise ukungaphumeleli kwesibindi kunye neengxaki zokungaphumeleli kwesibindi njenge-portal hypertension. IiNkcazo zijongwa njengamanje ngenxa yokukwazi ukunciphisa ukwanda kwesifo sesibindi kubantu abanesifo esingenalo utywala esinobunxila.
Ukongeza, abo baneesifo sesibindi ngenxa yokusuleleka kwe-hepatitis C engapheliyo bangaphendula kangcono kumachiza (interferon) xa banikwa i-statins. (Ingqalelo ukuba utywala buyingozi kakhulu kwi-hepatitis C. )
Kutheni Kutheni Ukusela Utywala Kubeka Ingxaki ngeLipitor?
Yonke loo nto ithe, ukusela utywala kunokubangela ingxaki kubantu xa kudibene ne-Lipitor. Ukunyuka kweemvavanyo zentsholongwane akusiyo kuphela yempembelelo yecala. Iingxaki ze-muscle kunye nama-statins aqhelekanga, kwaye utywala kunokukhokelela ekulimaleni. Utywala lungaphinda luphazamise umonakalo wezidakamizwa ezininzi, ezinje ezinokusetyenziswa kunye ne-Lipitor yesifo senhliziyo. Inkxalabo ebalulekileyo ngotywala kubantu abasebenzisa i-Lipitor, nangona kunjalo, mhlawumbi i-ingxaki yezinye iingxaki ezifumaneka ngotywala kuphela. I-Lipitor kunye neminye imimiselo inokunciphisa umngcipheko wesifo senhliziyo, kodwa utywala, ngenxa yezizathu ezinjenge-alcoholic cardiomyopathy kunye nokunye okuninzi, kungalimaza ingozi yakho. Kakade ke, utywala lunamatholeji amaninzi, into ephakamisa ingozi yesifo senhliziyo.
Ngaphantsi kweeNkcazo kunye noTywala
Into endiyifunayo ngokwenene kukuba, "Ngaba ndingenayo ibhiya okanye ezimbini okanye iglasi yewayini ngelixa ndithatha izitembu? Kungenzeka ukuba ukongeza utywala kwiimimiselo kunemiphumo encinci xa kusetshenziselwa ukumodareyitha.
Umbuzo wangempela uhla waya kuthi, "Ngaba unengxaki yokusela utywala?" Kulabo badla ixabiso eliningi lotywala (ngaphezulu kwezibini ezimbini ngosuku ngosuku lomntu okanye ngaphezulu kwesiselo esisodwa ngosuku ngosuku lwabesetyhini), kunokubakho okungakumbi ukukhathazeka malunga nokuba kunokuchaphazela isibindi sakho sokudibanisa i-statins notywala.
Ukusela kwiModareyitha-Iyintoni Ingcaciso?
Amaziko ase-United States yokuLawula nokuVikela (i-CDC) ichaza ukusela ngokumodareyitha njengesiselo esisiselo sosuku ngalunye kubafazi kunye neziphuzo ezimbini zamadoda. Ngokubhekisele kwiwayini, isiselo esisinye sinama-ounces amahlanu. Nangona kunjalo, abaphandi abafunda iziphumo ezixhamlekileyo zotywala ekukhuseleni izifo zentliziyo bachaza ukusela okucokisekileyo njengesiphuzo ezimbini kwiintsuku zowesifazana kunye neesiselo ezilishumi ngosuku ngalunye.
Ixhalabo ezinxulumene noTywala
Ukuba unamalungu entsapho okanye abahlobo abaye babonisa ukuxhalaba ngokusela kwakho, kubalulekile ukubheka ngokunyanisekileyo ukusetyenziswa kwakho. Ukuba uthe waphuza nonke, thabatha umzuzwana uze uzame le mibuzo ukuze ubone ukuba unako ukusetyenziswa kotywala.
Thetha noGqirha Wakho Ngokusebenzisa Utywala
Ukuba usela utywala kufuneka uvumele ugqirha wakho wazi. Abantu abaninzi banqabile ukungena kwabo, kodwa ukunyaniseka nogqirha wakho ekugqibeleni uya kukunyamekela ngokunokwenzeka. Ugqirha wakho uyazi imbali yakho yezobugqirha kunye nesimo sempilo yangoku kwaye kufuneka akwazi ukukucebisa malunga nokusetyenziswa kotywala.
Thatha ixesha lokufunda malunga neendlela zokonywa utywala nokuba unomdla malunga nawe okanye umhlobo okanye ilungu lentsapho. Ngombulelo, awunakuze uhambe kakhulu ukuva iindaba eziyimpumelelo ezivela kubantu abaye banikwe indawo entsha yokuqeshisa ubomi emva kokuyeka.
> Imithombo
- > Athyros, V., Alexandrides, T., Bilianou, H. et al. Ukusetyenziswa kwee-Statins kuphela, okanye kwiNhlanganisela yePioglitazone kunye nezinye iziyobisi, ukuPhathiswa kweZifo ezingabinxilongwane kunye neNyango yokuNxila kunye noTywala kunye neNgcaciso yengozi ye-Cardiovascular Risk. Ingxelo yePhaneli yeNkcazo. Metabolism . 2017. 71: 17-32.
- > Bjornsson, E. I-Hepatotoxicity yeeNkcazo kunye nezinye iAppid-Lowering Agents. KwiLiver International . 2017. 37 (2): 173-178.
- > Janicko, M., Drazilova, S., Pella, D., Fedacko, J., noP. Jarcuska. Iimpembelelo zePleiotropic zeeNkcazo kwiZifo zesibindi. I-World Journal yeGastroenterology . 2016. 22 (27): 6201-13.
- > Thapar, M., Russo, M., noH. Bonkovsky. Iimpawu zeNkcazo kunye neNyango yokuBala. Gastroenterology kunye neHepatology . 2013. 9 (9): 605-606.