Uphando luhlolisisa ukudibanisa okunokwenzeka phakathi kwe-celiac, ubuzwe obuninzi be-gluten kunye nengqondo
Nangona uninzi lwabantu lubheka isifo se-celiac kunye ne-non-celiac gulen senitivity kuba imeko ebandakanya kakhulu iinkqubo zabo zokutya, uphando lubonisa ukuba le miqathango ngokwenene ingaba nemiphumo ebanzi emzimbeni wakho, kubandakanywa namalungu akho, i-hormone yakho, kunye nengqondo yakho.
Ngenxa yoko, ngaba banokufaka isandla kwi-okanye nokuba bangela ukuba- isifo se-Alzheimer kunye nomqondo we-dementia ?
Ngethamsanqa, kubonakala kungenakwenzeka: ubungqina obuvela kwizifundo zezokwelapha kude kube ngokuthi ukungcola kwe-gluten akuphakamisi umngcipheko wesifo sengqondo se-Alzheimer okanye unesi sifo saloliac okanye ubuninzi be-gluten.
Izifo zeCeliac kunye nezifo ze-Alzheimer: Ziziphi ubungqina?
UDkt. Alessio Fasano, intloko yeziko laseMassachusetts General Hospital kwiCeliac Research and Treatment, uxelela ukuba uphando olutshanje, olwenziwa eSweden, lubonisa ukuba ukufumana isifo esiqhenqileyo asikongezeli umngcipheko wesifo sengqondo kunye ne-Alzheimer's disease.
Uphononongo lubhekisele kuma-8,846 abantu abaneminyaka engama-50 ubudala nangaphezulu abaye bafumanisa ukuba banesifo se-celiac besebenzisa i-biopsy yamathumbu ukuqinisekisa ukulimala kwamathumbu emathumbu, kwaye bafanisa nabantu abangama-43 474 abangenayo isifo se-celiac. Ubudala beminyaka yobudala bezinto ezifundiswayo beyiminyaka engama-63 ubudala.
Ngaphezulu kwexesha lokulandelela iminyaka engaphezu kwe-sibhozo, i-dementia yafunyaniswa kwi-4.3 ekhulwini yabanesifo esiqhekezayo kunye ne-4.4 pesenti yeqela lolawulo.
"Kuyaqinisekisa ukuba asizange sithole ingozi eyomeleleyo," kubhala ababhali.
Uphononongo luye lwafumanisa umngcipheko wokwanda kwengqondo yokuxilongwa komzimba ngethuba lonyaka wokuqala emva kokuxilongwa kwesifo se-celiac. Nangona kunjalo, lo mngcipheko awunakwandanga ngaphezu kwaloo nyaka wokuqala, kwaye abalobi beengxelo bathi mhlawumbi ngenxa yokuba abo bafundayo bavavanyiswa ngenyameko, kwaye izimo zonyango ebezikho kodwa zazingabonwa mhlawumbi ufumaneke kwaye uphathwe ngenxa yolu.
Umngcipheko we-Vascular Dementia ophakanyisiwe
Okumalunga noko, isifundo safumanisa ubuncipheko obuncinane besifo sengqondo somzimba-uhlobo lwesifo sengqondo sokubangela ukunyuka kwegazi kwi-brain yakho-phakathi kwabantu abanezifo eziqhekezayo. Oku kungabangela ingxaki, abalobi babhala, kuba abantu abanesifo esiqhekezayo sinomngcipheko owenyukayo wesifo senhliziyo, ephakamisa umngcipheko wokugula komzimba.
Kungenzeka ukuba lo mngcipheko we-vascular dementia ungabangelwa ngenxa yokungaphumeleli kwe- vitamin- ngokukhethekileyo, ukungabikho kwe-vitamin B12, ababhali abhale. Nangona kunjalo, uphando oluninzi luya kufuneka ukuze kuqinisekiswe ukuba oku kunjalo.
"Ukufumana kwethu ingozi yokunyuka kwengqondo kwe-vascular (and not Almheimer's 'dementia') kungabangelwa ngethuba kodwa kuphakamisa amathuba okuba ingqondo yesifo sengqondo ingaba ngumphumo wangexesha elide lesifo esiqhekezayo esichaphazelekayo esichengeni isifo se-cardiovascular and cerebrovascular disease , "abalobi baphetha.
Uphando olungakumbi malunga ne-Alzheimer's and Celiac
Nangona isifundo esivela eSweden bubungqina obuqinileyo bokuthi isifo se-celiac asiphakamisi umngcipheko we-dementia kunye nesifo se-Alzheimer, mhlawumbi asiyi kuba ligama lokugqibela kulo mbandela. Amaphando ambalwa asebekhulile acetyiswa ukuba ukungcola kwe-gluten kungadlupha okanye kubangele i-Alzheimer kunye nezinye iintlobo zengqondo yokugula komntu kubantu abanesi sifo.
UDkt. Fasano uthi ulindele ukuba uphando olungakumbi luqhube phambili luhlolisise le ngxaki: "Ukubona ngokwenene ukuba kukho ubuhlobo phakathi kwesifo se-celiac kunye nokusukela emva kokubuya kwesifo se-Alzheimer, sifuna izifundo eziza kulandela abantu ngexesha elide. , sinokukwazi ukubona indlela isifo se-celiac sichaphazela ngayo ukuphuhliswa kwesifo se-Alzheimer okanye ezinye iintlobo zesifo sokugula komzimba kunye nokuncipha kwengqondo. "
Olunye uphando lufumene ukuba i-subset yamajethi ehambelana nezifo ze-celiac kunye nezinye izifo ezizimele , eziquka i-rheumatoid arthritis kunye nesifo sesibindi sokuvuvukala, nazo zidibene nesifo se-Alzheimer.
Into eqhelekileyo ibonakala ivuvuka, abalobi bafunda babhala. Kodwa kwakhona, uphando olongezelelweyo lufunekayo kulawo majelo kunye nemiphumo yabo ukukhwabanisa nayiphi na inxibelelwano.
Akukho Ubungqina BamaBango kwi- Brain Brain
Usenokuba uqhelane ne-neurologist uDkt. David Perlmutter, umbhali weGrain Brain, owatsho iprotheni ye-gluten kwi-gluten okusanhlamvu kwengqolowa, ibhalley, kunye ne-rye (kwaye kwinqanaba elithile, zonke iinkozo) ekunciphiseni impilo yezobuchopho ukuba kwezinye iimeko iholele ekudemeni kwengqondo. Umyalelo wakhe ukugwema i-carb-based based carbs, ngakumbi i-gluten.
UDkt. Perlmutter's Grain Brain uxwayisa ukuba ingqolowa (kunye nezinye iinkozo) zibi kakhulu kwimpilo yengqondo kumntu wonke, kungekhona nje abo banezifo eziqhekezayo okanye izilwanyana ezingenalo celiac. Usola ukwanda kweeshukela zegazi ezixhomekeke ekusebenziseni okusanhlamvu, besithi oku kubangela ukukhuseleka kwe-insulin kunye nesifo sesifo seesifo, isifo sikashukela, kwaye ekugqibeleni ukuhla kwengqondo kunye nokugula komzimba.
Ingxaki kukuba, izigqibo ze-Permutter zixhaswa ngokukodwa ngobubungqina bakhe bokuqala, kwaye azixhaswa ngophando oluthile lwezonyango. Akukho bungqina bobunzululwazi obubonisa ukuba i-gluten kunye / okanye iinkozo zingabangela isifo se-Alzheimer okanye ezinye iintlobo zomqondo weengqondo.
Ukuvuvukala kunye ne-Microbiome
Omnye usosayensi ofundayo umbuzo wokuba i-gluten ingestion ingabangela ingqondo ekungabikho komqondo kubantu abangenalo-celiac gluten uzwela nguDkt. Mak Daulatzai, i-cardiologist kunye nophando lwezonyango oluphezulu kwiYunivesithi yaseMelbourne e-Australia. Ngokutsho kwephepha le-2015 nguDkt. Daulatzai, ukuguqulwa kwimizimba yakho ye-microbiome ebangelwa yi-non-celiac-sensitive gluten kungabangela ukuvuvukala komzimba, okuya kuthi kukhokelela ekungciphekweni komngcipheko we-Alzheimer's disease.
UDiulatzai uthi: "Imizimba yethu iyinyamezela ukutya okuthe gqolo kwaye ayiyikunyusa imfutho ye-immunological reaction." "Nangona kunjalo, kwimeko ye gluten, [ezinye izidumbu zabantu] zijonga ukuba yinto engcolileyo," kwaye usabele ngayo. Oku kubangela ukuvuvukala, uthi, kwaye "kunokubangela ukubonakaliswa kwengqondo / yeengqondo kunye neyentliziyo" ye-non-celiac gluten senitivity, ezinokubandakanya ukugula komqondo.
UDkt. Daulatzai uthi le ndlela yokucetywa kwengqondo yokuhlala kwengqondo ihlala isengqiqweni kwaye ingakhuselekanga, nangona iqaphela iqela lakhe liqhuba uphando olungayibuyisela imfundiso yakhe.
Ngaphantsi
Ubungqina bokuba bubonisa ukuba ukufumana isifo se-celiac asiphakamisi umngcipheko wesifo se-Alzheimer okanye isifo sengqondo sokugula. Okwangoku, akukho bungqina bonyango obonisa ukukhathazeka kwe-gluten kunokuphakamisa umngcipheko kwiimeko ezinxulumene nengqondo-nangona uphando lukaDkt. Daulatzai lucebise indlela enokuthi idibene ngayo, ihlala ingavumelekanga kwaye iqikelele.
Nangona i-gluten-free food inezinzuzo ezibonakalayo kwimpilo yakho ukuba unayo isifo se-celiac okanye u-sensitivity ye-gluten, ngelishwa awukwazi ukuxhomekeka kukukhusela kwisifo se-Alzheimer okanye u-mententi. Ngethamsanqa, kukho ezinye iindlela onokukunceda ukunciphisa umngcipheko we-Alzheimer's , kuquka nokuzilolonga (kokubili ngokomzimba nangokwengqondo).
> Imithombo:
> Daulatzai MA. Ubunzima be-Celiac Gluten Ukukhathazeka Okubangela ukuba i-Dysbiosis, i-Neuroinflammation, i-Gut-Brain i-Axis Dysfunction, kunye ne-Vulnerability ye-Dementia. I-CNS & Neurological Disorders - Iithagethi Zeziyobisi. 2015; 14 (1): 110-31.
> Lebwohl B et al. Umngcipheko weDementia kwizigulane ezinezifo eziCeliac: Isifundo soLuntu oluSebenziweyo. Ingxelo yeZifo ze-Alzheimer's. 2016; 49 (1): 179-85.
> McKeon A et al. I-Neurologic Ukubaluleka kwamaCeliac Disease Biomarkers. Neurology. 2014 uNgo-11; 83 (20): 1789-96.
> Yokoyama JS et al. Umbutho Phakathi kweeMpawu zeGenetic zeZifo eziMzimba kunye neAlzheimer's disease. JAMA Neurology . 2016 Juni 1; 73 (6): 691-7.