Ijusi yamagilebhisi iyaziwa ukuba inxibelelanise nenani lamachiza , ukwandisa umphumo kwinqanaba elinobutyhefu. Ngoko ke, xa kuziwa ku-Plavix (clopidogrel), igazi elincinci lonyango elisebenzisa ukunciphisa ukuxhaphaka kwe-stroke kunye ne-myocardial infarction, ngaba kuphephile ukuyidla isiphumo sesithelo? Impendulo emfutshane "ayikho."
I-Jupefruit Juice ihambelana njani ne-Plavix?
Uphononongo luka-2014 olufumene iJaji ye-grapefruit inqanda zombini i-CYP3A4 enzyme, apho i-clopidogrel yintsimpsi, kunye ne-CYPC19 enzyme, eyenza i-drug-drug isilumali.
I-jupe ye-Grapefruit inokuthi iphazamise ukuguqulwa kwe-clopidogrel kwifomu yayo esebenzayo, ngoko ukunciphisa i-antiplatelet yempembelelo yonyango efunekayo ukukhusela ukubetha okanye ukuhlaselwa kwentliziyo.
Emzimbeni, i-clopidogrel isetyenziswe ngokusetyenziswa kwe-CYP2C19 enzyme. Nangona kunjalo, abantu abathile bangama-poorabolizers ase-CYP2C19. Aba bantu abanqabile kwi-clopidogrel. Nangona kukho ukuhlolwa kwegazi ukufumanisa izigulane ezingapheliyo kwi-clopidogrel phambi kweziko leyeza kunyango, le mvavanyo ayisebenzisi ngokubanzi. Ingqalelo, abantu abahluphekileyo be-clopidogrel metabolizers, nabo banomngcipheko owenyukayo wokufa kweziganeko zentliziyo okanye i-thrombosis.
Ngokombiko we-FDA, ezinye iiliti zentliziyo ezithatha i-jupe fruit juice zibandakanya:
- imimiselo (njengeZocor kunye neLipitor)
- Imishanguzo yegazi njengesi-nifedipine
- amachiza okulwa ne-arrhythmia njengama-amiodarone
Ukongeza kwiyeza zentliziyo, i-juice yamagilebhisi iyathintela ezi zi yobisi:
- amayeza asetshenziselwa ukufakelwa komzimba njenge cyclosporine
- amayeza anxamnye noxinzelelo njengebhasipirone
- antihistamines njengeAlgragra
Ijusi yamagilebhisi ingaba yinkalo enempilo yalo naluphi ukutya. Ukuba unamayeza entliziyo, nceda uxoxe ukuba ingaba yinto efanelekileyo yokusela isantya samagilebhisi kunye nodokotela wakho okanye omnye umboneleli wezempilo.
Qinisekisa ukuxelela umboneleli wakho wezempilo yonk 'imithi oyithathayo kunye namadayira ala mayeza.
ILizwi
Kusoloko kuluvo oluhle lokufunda ngokucophelela ukushicilela okushicilelweyo okuza ne-clopidogrel. Kufuneka kubekho icandelo malunga nokusebenzisana phakathi kwe-clopidogrel kunye namanye amayeza. Ukuba awuzange ufumane i-pack package, cela umkhompili wakho ikopi.
Ukuba usebenzisa iipilisi ezingaphezulu kwe-counter-the-counter (i-OTC) okanye i-supplementary dietary, kufuneka uxoxe nekhemistiki kunye nodokotela malunga nokusebenzisana. Kufuneka uqaphele ngakumbi ngokusebenzisa imishanguzo yokuvuvukala njenge-ibuprofen kunye ne-OTC izongezelelo eziqukethe i-ginkgo. Umphumo wecala wale mveliso uyaphala.
> Imithombo:
> Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. I-jupe ye-Grapefruit inqanda ukusebenza kwe-clopidogrel. Clinic Pharmacol Ther . 2014 Inkcazo: 10.1038 / clpt.2013.192
> IKrasowski MD. Pharmacogenomics. Ku: South-Paul JE, Matheny SC, Lewis EL. eds. UKUPHATHWA KWESIFUNDO NOKUPHATHWA KWEZINDAWO: I-Medicine yentsapho, 4e . New York, NY: McGraw-Hill; 2015.
> Trevor AJ, Katzung BG, iKruidering-Hall M. Pharmacogenomics. Ku: Trevor AJ, Katzung BG, iKruidering-Hall M. eds. I-Katzung & Trevor's Pharmacology: UkuHlola kunye nokuHlola kweBhodi, 11e . New York, NY: McGraw-Hill; 2015.