I-Alpha-ketoglutaric acid iyinto efunyenwe ngokwemvelo emzimbeni womntu. Kwakhona kufumaneka kwifom ye-supplementary diet, i-alpha-ketoglutaric acid idlala indima ebalulekileyo kumjikelezo weKrebs (uluhlu lweempendulo zamakhemikhali ezibandakanyeka kwimveliso yomzimba). I-alpha-ketoglutaric supplement supplementation is required to offer various types of health benefits.
I-Alpha-ketoglutaric acid nayo ivela kwifomu yetyuwa, njengento ebizwa ngokuthi i-alpha-ketoglutarate.
I-Alpha-ketoglutarate ibandakanyeka ekwakheni i-glutamine, i-amino acid efunekayo kwi-protein synthesis kunye nokusebenza kakuhle kwe-immune system.
Ukusetyenziswa
I-Alpha-ketoglutaric acid isoloko kuthiwa ikhuthaza ukusebenza kwezemidlalo. Ezinye iziphakamisi zonyango ezongezelelweyo zithi ukusetyenziswa kwe-alpha-ketoglutaric acid kunokunceda ukuveliswa komzimba weprotheni, ukuzinzisa izinga lokushukela kwegazi ngexesha lokuzivocavoca, nokuphucula ukunyamezela.
Ngenye iyeza, i-alpha-ketoglutaric acid ithetha kwakhona ukunceda ngeengxaki zezempilo ezilandelayo:
- ulwasulelo lwebhaktheriya
- neengxaki
- isifo sesifo
- imvubelo yesifo
Izinzuzo
Nangona uphando ngemiphumo yempilo ye-alpha-ketoglutaric acid iyancipha kakhulu, uphando oluthile lubonisa ukuba i-alpha-ketoglutarate inokunika iinkonzo ezithile zezempilo. Nanku ukukhangela kwiziphumo ezininzi eziphambili kwiziphumo ezikhoyo:
1) iHemodialysis
I-Alpha-ketoglutarate inokuba yinzuzo ethile kubantu abaphantsi kwe-hemodialysis.
Kuphando olupapashwe kwiphepha leNifron ngo-1996, abaphandi bafumanisa ukuba ukulawula i-alpha-ketoglutarate kunye ne-calcium carbonate kwizigulane ze-hemodialysis zanceda ukukhulisa i-amino acid metabolism kunye nokunciphisa i-hyperphosphatemia (imeko ephawulwe ngamanqanaba angaphakanywanga e-phosphate egazini).
2) Ukuvuthwa kweCardia
I-Alpha-ketoglutarate inokukunceda ukuphucula umsebenzi wezintso phakathi kwezigulane ezenziwa ngophando lwe-cardiaac, ngokuphathelele uphando olwenziwa ngo-1998 oluvela kwi- Annals of Thoracic Surgery . Uhlolisiso lwabandakanya abantu abangama-22 abaneentsholongwane eziqhelekileyo ngaphambi kokuba baphethwe ngumzimba. Kulao gulane, abantu aba-11 bafumana ukunyuka kwe-alpha-ketoglutarate ngeyure emva kokuhlinzwa kwabo. Iziphumo zoFundo zibonisa ukuba i-alpha-ketoglutarate inokuphucula ukuhamba kwegazi ezintso.
3) Ubude obude
Uphononongo lwe-2014 olupapashwe kwiNdalo ibonisa ukuba i-alpha-ketoglutarate ingabonisa isithembiso ekunyuseni ixesha elide. Kwiimvavanyo ze-neematode ze- Caenorhabditis elegans , abalobi beengcali bafumene ukuba i-alpha-ketoglutarate iphazamise ukuveliswa kwamandla weselula kwaye imilisa imiphumo yezilwanyana eziphantsi kakhulu kwiikhalori, eziye zaboniswa ukwandisa ubomi bezilwanyana ezithile. Ngokutsho kwababhali bokufunda, i-alpha-ketoglutarate yandisa ubomi beepompo eziphathwayo malunga nama-50% ngaphezu kolawulo olungaphendulwanga. Kufuneka uphononongo olongezelelweyo ukuze ubone ukuba zeziphi iziphumo eziza kubakho kubantu.
Imijelo
Ngenxa yokungabikho kophando, uncinci luyaziwa ngokhuseleko lwexesha elide okanye oluqhelekileyo lwezongezelelo eziqukethe i-alpha-ketoglutaric acid.
Nangona kunjalo, kukho inkxalabo yokuba ukusetyenziswa kwe-alpha-ketoglutaric acid kungamcaphukisa isisu kunye / okanye kuphazamise isisu.
Kubalulekile ukugcina engqondweni ukuba izongezelelo azange zivivinywe ukukhusela kunye nezondlo zokutya zikhululekile. Kwezinye iimeko, loo mveliso inokuhambisa amaxabiso ahluke kwixabiso elichaziweyo kwiyeza ngalinye. Kwezinye iimeko, loo mveliso inokungcoliswa nezinye izinto ezifana nezitye. Kwakhona, ukhuseleko lwezongezelelo kubasetyhini abakhulelweyo, oomama abangabongikazi, abantwana, kunye nalabo abanezifo zonyango okanye abathabatha imishanguzo ayilwanga.
Unokufumana amanye amathiphu ekusebenziseni izongezo apha .
Ezinye iindlela
Amanye amanyathelo angokwemvelo angasetyenziswa ekuphuculeni ukusebenza kwezemidlalo. Ngokomzekelo, uphando lubonisa ukuba i-branino-chain chain i-amino acids ingakunceda ukuphucula ukusebenza komzimba nokukhusela ukukhathala ngexesha lexesha elide lokuzivocavoca.
Ukongezelela, i-phosphatidylserine supplementation ifunyenwe ukukhulisa umthamo wokuzivocavoca, kunye nokunciphisa ubuhlungu besisu kunye nokukhusela ngokunyuka kwamazinga e-cortisol (i-hormone ekhutshwe ngexesha loxinzelelo) oludla ngokukhawuleza ekugqibeleni.
Kukho ubungqina bokuthi ukudala kunokunyusa intsebenzo ekuphakameni okukhulu, imisebenzi emfutshane (njengokuphakamisa isisindo kunye ne-sprinting).
Kuphi Ukuyifumana
Efumaneka ukuthengwa nge-intanethi, i-alpha-ketoglutaric acid idayiswa kwiindawo ezininzi zokutya zendalo, izikhuselo zezilwanyana, kunye neendawo zokugcina izakhono zokutya.
ILizwi
Ngenxa yophando olutshanje, ngokukhawuleza ukunyusa i-alpha-ketoglutaric acid kwiphina imeko. Kubalulekile ukuba uqaphele ukuba ukuzithobela impilo ye-alpha-ketoglutaric acid kwaye ukuphepha okanye ukulibazisa ukunakekelwa okuqhelekileyo kunokuba nemiphumo emibi. Ukuba ucinga ukuwusebenzisa, qiniseka ukuba udibane nodokotela wakho.
Imithombo
I-CHM, i-Fu X, i-Pai YAM, i-Vergnes L, i-Hwang H, i-Deng G, i-Diep, i-Lomenick B, i-VS i-Me, i-Monsalve i-G, i-Hu E, i-Whelan SA, i-Wang JX, i-Jung G, i-Solis i-GM, i-Fazlollahi i-F, i-Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, uFrand AR, iHuang J. "I-metabolite α-ketoglutarate yandisa ubomi ngokuvimbela i-ATP synthase ne-TOR." Uhlobo. 2014; 509 (7500). dx.doi.org/10.1038/nature13264
Jeppsson A, Ekroth R, Friberg P, Kirnö K, Milocco I, Nilsson FN, Svensson S, Wernerman J. "Imiphumo emibi ye-alpha-ketoglutarate emva kokusebenza kwe-coronary." Ann Thorac Surg. Ngo-1998 uMar; 65 (3): 684-90.
URedel E, uNündel M, uHll H. "Isicelo se-Alpha-Ketoglutarate kwizigulane ze-hemodialysis ziphucula i-amino acid metabolism." Nefron. 1996; 74 (2): 261-5.
Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onelayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.