Ngaphambi kokuba siqale, ndifuna ukugxininisa ukuba abo banomdla kwibali lonke lolo unyango lwezesondo zesini , eli nqaku malunga nepatch testosterone kufuneka lifundwe kwimiqathango yamanye amanqaku endibhalileyo: I- Viagra yabasetyhini kunye entsha-kodwa engavumelekanga - ipilisi ye-sex flibanserin . Ngokukodwa, ipattosterone ipatch ibonisa isitifiketi esiphakathi sale ntlupheko yezesondo zesifo sezesondo: indlela eyazama emva kokuba i-Pfizer inqume ukuxosha i-Viagra kubasetyhini naphambi kokuphuhliswa kwe-flibanserin, isicatshulwa sesini esinikwa sisini esilungisa amanqanaba e-neurotransmitter.
Izifundo malunga nokuxhatshazwa kwezesondo zabasetyhini
Ukuqukumbela kwazo zonke iinzame zokwenza unyango lwezesondo zentsebenzo yezesondo ukuya kwinqaku le-1999 elipapashwe kwi- JAMA ebizwa ngokuba yi-"43-31". Abaphandi beli phofu ba bonisa ukuba abafazi abangaphezu kwezi-4 kwabangama-10 (iipesenti ezingama-43) baneengxaki zesini xa kuthelekiswa nama-31 ekhulwini lamadoda. Olu phofu luchaza okokuqhubekayo ukuxubusha kuyo yonke ingxoxo malunga nokunyangwa kwezesondo zesini; ukuxuba amaqhinga okuxuba amayeza kunye neengcali ezininzi zezocansi kwelinye icala, kunye nabagxekayo bathi ukugulisa imeko yesondo njengomnye umzekelo "wesifo sengqondo" ngaphesheya.
NgoJuni 21, 2004, iProtector & Gamble isicelo se-FDA imvume yenkqubo entsha ye-testosterone ye-transdermal (i-jargon ye-testosterone patch), i-Intrinsa. Intrinsa yayijoliswe ngokuthi:
Unyango lweengxaki zengcinezelo zesini esingazenzisiyo kwisifo se-menopausal esiphezulu sokufumana unyango lwe-estrogen. Ingxaki yokuxhatshazwa ngokwesini (HSDD) yintlupheko eqhubekayo okanye ephindaphindiweyo okanye ukungabikho kweengcamango zesondo, iingcamango, kunye / okanye umnqweno wokufumana okanye ukufumana isenzo somsebenzi wesondo, okubangela ubunzima bodwa okanye ubunzima bobuqu. Umnqweno ophantsi wezesondo ungadibana nomsebenzi ophantsi wezesondo, iingxaki zokuvusa isondo okanye ubunzima be-orgasm.
Njengoko kuphawulwe kwimbali yam esesidlulileyo yentsholongwane yobundlobongela besifazane, i-HSDD lixesha elidlulileyo. Ngamhla, i-DSM-5 ikhuluma "ngentsapho yokukhupha isondo / intswela-mdla" edibanisa iingxaki zomnqweno kunye nokuvusa kwiziko elilodwa lekliniki.
Iziphumo ezisuka kwi-P & G zeSigaba sesi-3 zivavanyo zonyango zibonisa ukuba kwabasetyhini abaneziganeko ezivuyisayo zesini ngo-2 ngenyanga, ukulawulwa kwama-300 μg (kodwa akukho 150 μg okanye 450 μg) idibaniswe nesiganeko sokwanelisa ngesinye ngesondo ngenyanga.
Ngezizathu ezi-2 ezicacileyo, i-FDA yenqwenela ukuvuma i-Intrinsa. Okokuqala, ezi ziphumo ziyikliniki ezingenanto. Kubantu abasele benesondo esoloko neyanelisayo , i-testosterone patch ikwandisa inani leziganeko eziyanelisayo ngesondo ngenyanga! Okwesibini, ngenxa yesi siganeko esisodwa esonelisayo ngesondo, abafazi abanomdla wokuqhathaniswa nokuqhathaniswa kwezidakamizwa abaye bathatha i-estrogen baza kuboniswa kwenye i-hormone eyingozi, i-testosterone. Makhe ndicacise.
Ngeli xesha i-P & G isetyenziselwa ukuvunyelwa kwepatch yayo ye-testosterone, wonke umntu wayekhupha ngokukhawuleza ngeziphumo ezivela kwii-Women's Health's Initiative studies ekuhloleni i-hormone supplementation. Ngelo xesha, iziphumo ezivela kulezi zifundo ziphakamisa ukulawulwa kwe-estrogen kunye ne-progesterone kubasetyhini emva kwe-hysterectomy kwandise umngcipheko weziganeko ze-cerebrovascular (cinga ukuphazamiseka), iziganeko zenhliziyo kunye nomhlaza wesifuba. I-FDA yagqiba ukuba ngaphandle kokuqhutyelwa kwexesha elide lokufunda, kunokuba yingozi ukunika abafazi be-postmenopausal testosterone kunye nezinye i-hormone. Ingqalelo, uphando lwangaphambili lwe-P & G luhlolisise ukuxhaswa kwe-testosterone kubathathi-nxaxheba kwiiveki ezingama-52 kuninzi.
Ngenxa yokuhlaselwa kuka-FDA, i-P & G yabona ukungabi nantoni yokuxosheza umcimbi kwaye yawa i-Intrinsa.
Ekubuyiseleni, kuyacaca ukuba uP & G wayenethemba lokuba oogqirha babeza kunika itekiti ye testosterone yokusetyenziswa kweleyile-ngokukodwa, kwabasetyhini ngaphandle kwalabo abaye bavalelwa emva kokuhlinzwa kwamadoda. Ngokungabikho kokufundwa kwexesha elide, nangona kunjalo, i-FDA yayicatshukiswa yile nto.
Kukho ezinye iziphumo zophando eziza kubuza nokusebenza ngempumelelo kwe testosterone njengongenelelo kubantu abanobudlobongela besini / ingxaki yomdla. Okokuqala, asikho ubungqina bokusebenza kwe-androgen ephantsi kwabasetyhini abaneentsholongwane zesondo. Okwesibini, nangona singakwazi ukulinganisa i-intracrine okanye i-intracellular level testosterone, asikwazi ukulinganisa amanqanaba e-testosterone kwinkqubo ye-nervous central.
Amanqanaba eTesttosterone kwinkqubo yesantya ephakathi ayenawo umphumo omkhulu ekuvukeleni kunye nomnqweno.
Ngaba Abasetyhini Bayafuna I-Testosterone Eninzi?
Ngamanye amagama, asikwazi ukuba ngaba i-testosterone level in brain and spinal cord of those with sexual disadvantage is insufficient ngokwaneleyo ukuze ifune ukuxhaswa kwe testosterone, ukuqala. Okwesithathu, nakwii-testosterone gels kunye neepatches eziye zenziwe ukuphatha abantu, asikwazi ukuba uninzi lwe-testosterone lithatha ukuthatha ingqalelo ngokukwenziwa kwenkqubo yokongezwa kwe testosterone.
Kodwa nantsi into. Kubafazi abaninzi, ukufikelela kwi-testosterone ngenye indlela kuyenzeka. Ngokomzekelo, abafazi abaneengxaki zesondo zesini / intsingiselo yentswela-mdla bangakwazi ukumisela i-testosterone gels kunye neepatches off-ilebula (ukuthatha imithi yamadoda). Izongezelo zeTesttosterone nazo ziza kwiifom ze-naturopathic ezingathengwa kwi-Intanethi. Ekugqibeleni, kwamanye amazwe, i-testosterone ngamanye amaxesha inikezelwa kwabasetyhini abaneentlobo zesini.
Ngoko ke konke kukho, kusekho iindlela zokufumana izandla zakho kwi testosterone ukuphatha ukungasebenzi kwezesondo zesini ; Nangona kunjalo, sinikwe into esiyayaziyo, mhlawumbi ingcamango enhle yokukhupha izinto. Uphando alubonisi inzuzo yangempela yekliniki yokuncedisa i-testosterone kubasetyhini abaneentlobano zesini zesini, kunye nathi asiyazi nokuba amazinga e-testosterone awanakho nawabasetyhini abanezenzo zesondo ngokokuqala. Kwaye, ke, i-testosterone i-hormone, kwaye i-hormone iye yaziwa ngokuba neempembelelo ezinobungozi ezinjenge-stroke, i-blood clots, umdlavuza njalonjalo.
> Imithombo:
> I-athikili > ebizwa ngokuthi "iTranstosterone yonyango yokunciphisa i-libido kubasetyhini" ngo-R Basson eyapapashwa kwiNtsholongwane ye-Endocrinology kunye ne-Metabolism eyapapashwa ngo-2010. Ifikelele ngomhla we-3/13/2015.
> Iqendu > elibizwa ngokuba yi-Pinking of Viagra: Imveliso yezobisi ukuzama ukudala nokuxhatshazwa kwezidakamizwa zesini kwabesetyhini "nguHoseph Hartley opapashwe ngoBuchule ngo-2006. Ufikelele ngomhla we-3/15/2015.