Iphilisi ye-Sex Flibanserin ixutywe kwiDrama
Kwabanqabileyo bayo, i-flibanserin, ipilisi epinki ejoliswe kwi-libido ye-femidi kwaye eyenziwe yi-Sprout Pharmaceuticals, ingomnye umzekelo wesifo sengqondo. Izifo zengqondo zibhekiselele kwinkqubo yeenkampani zonyango kunye nabanye "ukuxhomekeka" kwiimeko zomntu ukwenzela ukwenza i-buck. Ngokomzekelo, i-halitosis okanye ukuphefumla kakubi kwaba yimeko efuna unyango emva kokuba uListerine yenziwe ukuba "yiphathe".
Nangona kunjalo, kubaxhasayo bayo, umdla wesini wesini / ingxaki yokuvusa isifo esiyinyani, kwaye i-flibanserin inokukunceda. Aba baxhasi bakhankanya uxinzelelo olwenziwe ngumqhubi wesini ophantsi okanye ongabikho.
Yintoni inomdla wesondo / i-Arousal Disorder?
Umdla wesini wesini / ingxaki yokuvusa ibhekisele ekunciphiseni okanye ukungabikho komdla wesini kwintombi ehlala kwiinyanga ezili-6 okanye ngaphezulu kwaye ibangela uxinzelelo okanye ubunzima bobudlelwane. Ngaphezu koko, ukuphazamiseka okunjalo akunakuxhamla kwesinye isifo (cinga ngesifo sikashukela okanye ukudakumba) okanye iziyobisi (cinga ukuxinzezeleka). Kubalulekile ukuba ukulahleka kwesifiso sesini kubangela uxinzelelo okanye ubunzima kuba, ngaphandle koko, akunjalo ingxaki. Emva kwakho konke, abantu abaninzi banomdla wokuhlala ngesini eside ongabangela iingxaki zabo, kwaye oku kulungile.
Abaphandi bafuna ukuba umdla wesini wesini / ukuphazamiseka kwengxaki kubandakanya ukujikeleza kweengqondo ezijikelezayo zokulawula umvuzo.
Ngokukodwa, le meko ichaphazela iindlela ze-frontostriatal kunye neembono ze-neuronal ze-insula, i-amygdala, i-hypothalamus kunye ne-ventral striatum. Kubasetyhini abanomdla wesondo kunye nemibandela yokuvusa, ukuxhaswa ngokwesini kunye nokuzonwabisa kuyathinteka kakubi. Ingqalelo, ukulungiswa komvuzo wokuhlawula okunye okunye okunye okubandakanya ukuphazamiseka kwengqondo, kuquka ukudakumba, i-schizophrenia, ukusetyenziswa kakubi kweziyobisi, ukuphazamiseka komzimba, ukuphazamiseka kokutya kunye nezinye iingxaki zesini.
Kuyathakazelisa, abaphandi baye bafumanisa utshintsho kwi-MRI esebenzayo ebonisa ukukhubazeka kwe-macrocircuit echaphazelekayo kumdla wesini wesini / izifo zokuvusa. Ngokomzekelo, abasetyhini abafumana ukuba le ngxaki baveza ukusetyenziswa okungavumelekanga kwimimandla yeengqondo kunye nebala.
UFlibanserin Usebenza njani?
Kunzima kakhulu (akunakwenzeka) kwizenzululwazi ukulinganisa amanqanaba athile e-neurotransmitter kwiindawo ezahlukeneyo zobuchopho. Nangona kunjalo, ukusebenzisa amacandelo e-microdialysis kunye neengcingo kwiinkonzo zengqondo, abaphandi bacacisa ukuba i-flibanserin yandisa ukukhululwa kokubili kwe-dopamine kunye ne-norepinephrin kwaye kunciphisa ukukhululwa kwe-serotonin kwabasetyhini abanomdla wokunciphisa isondo kunye nomnqweno. Ngokukodwa, i-flibanserin inokuhlukanisa phakathi kwe-receptor ye-serotonin kwaye ivuse i-serotonin 5HT1A i-receptors ngelixa ivimba i-serotonin 5HT2A i-receptors kwi-correx ye-prefrontal ngokunyusa ukukhululwa kwe-dopamine kunye ne-norepinephrine. Kuyabonakala ukuba, ezi zinto zidibanise nemiphumo ye-neurotransmitter zinceda ngokubhetele ukulawula umvuzo kunye nokwandisa i-femido libido.
Ingqalelo ethile, i-flibanserin isebenza kuma-neurotransmitters, kungekhona ama-hormone. Nangona ama-hormone aphumelele ekuphuculeni i-libido, imiphumo emibi yenza ukuba ibe yingozi njengonyango.
Ngaphezu koko, i-flibanserin ayikho "i-Viagra yowesifazane." I-Viagra isebenza ngokwandisa ukuhamba kwegazi ukuya kwizitho zangasese esebenzisa indlela eyahlukileyo kwaye ichaphazela isayithi elithile lezenzo (izitho zomzimba kunye nobuchopho).
Iziphumo ezivela kwizilingo ezimbini zeeklinikhi ezibizwa ngokuba yi-BEGONIA kunye ne-DAISY (ah, amagama eentyatyambo ... indlela enhle ngayo!) Ibonisa ukuba i-flibanserin inokwandisa i-femido libido. Edibeneyo, ezi zilingo ezinokulawulwa ngokulandelelana kunye ne-placebo zihlolisise abafazi abangama-3548 abanomdla wesondo kunye neengxaki zokuvusa. Emva kweeveki ezingama-24 zonyango lwe-100 mg flibanserin, iziganeko ezonelisayo zesondo, umnqweno wesini , kunye nokuxinzezeleka okubangelwa ngumnqweno ophantsi wesondo kulandelwa ukusebenzisa iimibuzo ezihlukeneyo (ezizimeleyo).
Abaphandi baqaphele ukuba kubathathi-nxaxheba bathatha i-flibanserin-xa kuthelekiswa nalabo bathatha indawo-kwakukho ukwanda kwintlanganiso yesini eyanelisayo kunye nenqanaba lesifiso sesondo kunye nokunciphisa ubunzima obangelwa ngumnqweno ophantsi wesondo.
Iziganeko ezibi kakhulu kulezi zilingo zenzeke ngaphantsi kwepesenti enye yabathathi-nxaxheba, kwaye akukho nanye yeziganeko ezinzulu ezibangelwa unyango lwe-flibanserin ngokwayo. Imiphumo embi engathintekiyo ibandakanya ukungcola, isicathulo, ukukhathala nokulala (eziqhelekileyo).
Olunye uvavanyo olulinganisekanga nolugunyazisiweyo olubizwa ngokuthi yi-SNOWDROP (Ndiyibona ipatheni, apha ... elinye igama leentyatyambo!), Yahlola abafazi abangama-949 be-postmenopausal abanomdla wesini / isondo sokuvusa I-TR ethe yaguqulelwa kwisithakazelo socansi / ingxaki yokuvusa kwi-DSM-5). Kunjengezinye izilingo, iziphumo zibonisa ukuba i-flibanserin iphucula umnqweno wesini, inani lezenzo eziyanelisayo zesini kunye nokunciphisa uxinzelelo ngokwesini nangona kubangela imiphumo embalwa emibi. Ngokukodwa, ama-37.6 ekhulwini kwabasetyhini kwi-flibanserin ngokumalunga nama-28.0 ekhulwini kwabasetyhini abenza indawo yokuhlala babika iziganeko ezonelisayo zesondo.
Nangona kwezinye zezicwaningulu zabaphandi bazama ukubandakanya abathathi-nxaxheba bathatha imithi yokuxhatshazwayo, ama-antihypertensives, ama-triptans kunye nezinye izifo ezikhuselekileyo, enye imida ephakamileyo yalezi zifundo yintlupheko. Ngamanye amazwi, ngenxa yokuba imiba yesondo kunye nomnqweno ixhaphake kwaye ichaphazela zonke iintlobo zabasetyhini, kwakunzima ukuvavanya ukuba i-flibanserin isebenza kuwo wonke umntu.
Ukukhankanya ukuxhalaba malunga nokukhusela nokusebenza, i-FDA inqwenela ukuvuma i-flibanserin-ukuchaswa kabini apho umenzi wayo, i-Sprout Pharmaceuticals kunye nabanye bakhipha. Ukusuka kwindlela yokwelapha yonyango, ngokuqinisekileyo ndivelana neengxaki ze-FDA. Emva kwakho konke, izixhobo ze-flibanserin ezinamaqela angama-neurotransmitters kwaye zicinga ukuba abaninzi bebhinqa abaza kuthatha isibisi baya kuthatha nezinye iziyobisi eziza kuguqula amanqanaba e-neurotransmitter - njengabadandlululo kunye ne-anxiolytics - kukulungele ukuthatha isilumkiso.
Isiphelo
Abantu abaninzi abanokwenene bengazi ukuba bacinga ntoni nge-flibanserin. Ngakolunye uhlangothi, abantu abaninzi banokukrokrela iinkampani zonyango kunye neenjongo zabo kwaye baqikelele ukuba ukuba kuvunyelwe, i-flibanserin inokugqithiselwa kubafazi abathile abanjengabo abangenaso uxinzelelo olunxulumene nokusweleka kwesondo okanye ukuvusa. Kwinqaku edibeneyo, yonke into malunga nokuthengiswa kwe-Sprout ye-flibanserin imemeza ukuguqulwa kuquka umbala wepilisi onomhlaza kunye nezilingo ze-clinical-monikered clinical. Ngakolunye uhlangothi, kunzima ukuqonda imiphumo ye-flibanserin ngaphandle kokuba ungowesifazane osebenzisa izilwanyana.
Imithombo:
I-athikili ethi "Ukusebenza nokukhuselwa kwe-flibanserin kwintombi yama-postopaopaus ne-hypoactive disorder disorder: iziphumo zetyala le-SNOWDROP" nguJA Simon kunye nabalobi ababambisene nabo bepapashwe ngexesha lokudluba kwexesha: I-Journal ye-North American Menopause Society epapashwe ngo-2013.
I-athimba ebizwa ngokuthi "Indlela yokusebenza ye-flibanserin, i-serotonin i-agonist kunye ne-antagonist (MSAA) emininzi ye-multi-functional (MSAA), kwisifo sengxaki esithintekayo ngokwesini" ngo-SM Stahl epapashwe kwi- CNS Spectrum ngo-2015.
I-athikili ebizwa ngokuthi "Ukuphucula amathuba okuphulukana nokukhathazeka kwesifo socansi (HSDD): isimo sengqondo sokuphuhlisa i-flibanserin" nguJ. Thorp, Jr, kunye nabalobi be- BJOG, epapashwe ngo-2014.