Uphando lubonisile ukuba kukho uxhulumano phakathi kwesifo se- nicotine nesifo sesibindi (IBD) . Nangona kunjalo, yintoni ephazamisayo kukuba ukutshaya kubonakala kunemiphumo eyahlukileyo kwiindlela ezimbini ezibalulekileyo ze-IBD-ulcerative colitis nesifo sikaCrohn.
Ukuqhagamshelana phakathi kwe-Ulcerative Colitis kunye nokuSuba
I-ulcerative colitis ibizwa ngokuba yintloko yezifo ezingabhemi.
Abokutshaya bade babesengozini enkulu yokuphuhlisa i-ulcerative colitis, ngelixa ababhemayo banomngcipheko omncinci. Olu tyekelo lubonisa ukuba ukutshaya ugwayi kunokuthintela ukuqala kwesilonda esiswini.
Abaphandi baye bafumanisa ukuba iicicin in cigarettes egxininisa inefuthe elihle kwiimpawu zesilonda esiswini. I-Nicotine yinto eyenziwa ngokwemvelo yocuba echaphazeleke kakhulu kwizitho ezininzi kunye neenkqubo ezisemzimbeni. I-Nicotine iphinde ibe ngumlutha, kwaye abantu abaninzi ababhema ugwayi banzima ukushiya naphezu kweengozi zempilo.
Kucatshulwa ukuba iicicin in cigarettes ichaphazela isisipha esilula ngaphakathi kwikholoni. Esi siphumo sinokutshintshisa umthamo we-gut (isantya apho impahla yokutya ihamba ngephepha le-GI).
Izifo zeNicotine kunye neCrohn
Ukubhema i-cigarettes ngokwenene kunefuthe elibi kwisifo sikaCrohn. Abantu abavuthayo, okanye abaye baphefumla kwixesha elidlulileyo, banomngcipheko ophezulu wokuhlaselwa kwesifo sikaCrohn kunokuba ababheki.
Izigulane zezifo zikaCrohn ukuba umsi unyuke inani lokuphindaphinda kwaye uphinde unyango kwaye lingafuna unyango olukhuselekileyo lwe-immunosuppressive. Abantu abanesifo sikaCrohn bakhuthazwa ngamandla ngamagqirha abo ukuba bayeke ukutshaya ukuze banqande ukutshabalaliswa kwesi sifo.
Umsizi wesibini
Umsi wesibindi kubantwana unempembelelo kwi-IBD.
Abantwana abonakaliswe ngumsi wesibambiso banomngcipheko we-ulcerative colitis kunye nobungozi obandayo bokukhula kwesifo sikaCrohn.
Ngaba Abesakuba ngabokutshaya abane-Ulcerative Colitis baphinde baKhanya kwakhona?
Ezinye iziphumo zibonise ukuba ababeshushu baqala ukukhupha i-ulcerative colitis baze baphinde babuyele ekubhekeni bafumana iimpawu ezimbalwa. Nangona kunjalo, ukutshaya ngokwalo kuthwala ezinye izingozi zempilo. Oogqirha abayi kucebisa ukuba isigulane siqale ukutshaya, njengoko izingozi zokubhema zigqithise kunanoma yintoni inzuzo enokwenzeka .
Kuthiwani Ngeentlanzi zeNicotine?
Ngoku ukuba i-nicotin patches (eyaziwa nangokuthi i-nicotin transdermal) iyatholakala ukuyeka ukutshaya, kunokwenzeka ukuba ufunde imiphumo ye-nicotine yodwa ngaphandle kokuvula umzimba kwezinye iingozi zempilo zokubhema. Impembelelo yesilwanyana isoloko ifundiswa ngabaphandi ngohlobo lovavanyo olwaziwa njengoluvavanyo olulawulwa yi-placebo. Kule hlobo lokufunda, ezinye izigulane zinikezwa izidakamizwa ezitsha, kanti abanye banikezwa ukulungiswa kwedummy (placebo). Akukho zigulane okanye oogqirha abafundayo bayazi ukuba ngubani ofumana iziyobisi kwaye ngubani ofumana i-placebo de ukuqhutyelwa isifundo.
Kwizifundo ezimbini ezilawulwa yi-placebo ezimbini eziyimpumpo, iifikitini ze-nicotine zifunyenwe zibe ngcono kune-placebo ekunciphiseni ukuxolelwa kwi-ulcerative colitis.
Ngelishwa, iziphumo ezibi kwiqela le-nicotine zaziqhelekileyo kwaye zibandakanya isicupunu, ubuhlungu obukhulu kunye nentloko. Abathathi-nxaxheba abafundayo abazange bafune ukufumana iziphumo zecala ngokukhethekileyo.
Kwesinye isifundo, abantu abane-ulcerative colitis abangasekhohlo abasesigxina abangazange baphendule unyango kunye nemilomo yomlomo banikezwa i-nicotine e-transdermal kunye ne-mesalamine enemas. Le nhlanganisela entsha inokusebenza ekunciphiseni ukuxolelwa kwabangu-12 kwabafundi abathathi-15.
I-Nicotine ayibonakali inenzuzo njengonyango lokulondoloza; akunakunceda izigulane zihlale zixolelwe. Kunoko, kubonakala kunemiphumo emihle kwizifo ezisebenzayo (i- flare-ups ).
Ukuthintela imiphumo ecaleni kwipaki, abaphandi bahlakulela iindlela zokukhulula iicicin ngqo kwikoloni. Kwisifundo esinye, i-capsule ye-nicotine yadalwa ukuba isebenze ngqo kwi-colon kwixesha leeyure ezingama-6.
Yintoni Yonke Ethetha Ngabantu Abanobuchopho Bomzimba?
Isiphumo esipheleleyo se-nicotine kwi-colitis yolceritis asikacaci, kodwa sibonisa isikhokelo esithembisa ukuphuculwa kwezilwanyana ezintsha. Njengendima ye-nicotine kwi-colon iyayiqondwa kangcono, izigulane ezinezilonda zesilonda zingasenelwa ngamanye unyango olutsha olusekelwe kulo mphumo.
Imithombo:
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UMahid SS, uMnin KS, uStromberg AJ, uGalandiuk S. "Ukubhema okusebenzayo nokungabonakali ebuntwaneni kuhambelana nokuphuhliswa kwesifo sesisu." I- Inflamm Bowel Dis Apr 2007 13; 431-438. 28 Meyi 2009.
Pullan RD, uRhodes J, uGanesh S, et al. "Ukutshintshwa kwe-nicotine ye-ulcerative colitis." N Engl J Meyi 1994; 330: 811-815. 28 Meyi 2009.
USandborn WJ, u-Tremaine WJ, u-Offord KP, et al. I-nicotine yokutshintshela i-accerative colitis. "Icandelo elilawulwa ngokungaqhelekanga, eli-double-blind, elilawulwa yi-placebo." U- Ann Intern Med Mar 1997; 126: 364-371. 28 Meyi 2009.
Sandler RS, uSandler DP, McDonnell CW, Wurzelmann JI. Ukuchasana kwabantwana kwimfucumfucu yengqumbo nomngcipheko we-ulcerative colitis. " Am J Epidemiol Mar 1992; 135: 603-608. 28 Meyi 2009.