I-angioedema ingaba yifa, kodwa ininzi yexesha ayikho. Kukho iimvavanyo zokuxilonga ezingakwazi ukuchonga i-angioedema yelifa.
I-Angioedema engengowona ifa iqheleke ukuba ixilongwe ngokusekelwe kwintsholongwane yesikhumba edibaniswe nembali yokukhutshwa kwento ebenokubangela ukuba i-reaction response. Ngamanye amaxesha, iimvavanyo zegazi zinokuxhasa ukuxilongwa, kodwa iziphumo azithethi ngokubhekiselele kwizinto ezingaqhelekanga.
I-Self-Checks / Ukuvavanywa Kwekhaya
Ungazijonga wena okanye umntwana wakho nge-angioedema. Ngokuqhelekileyo, iimpawu oza kuzijonga zibonakala ngokucacileyo ebusweni besikhumba, ngoko akudingeki ukuba uzifune.
Izibonakaliso onokuzijonga ziquka:
- Izindebe ezivuyiweyo
- Amehlo abuhlungu
- Ukuvuvuka kweengalo okanye imilenze
- Ukukhupha ulwimi lwakho okanye umqolo wakho
- Ukuvuvukala okungalindelekanga kuyo nayiphi na inxalenye yomzimba
- Ukuqhekeka: Ukuvuvukala kwe-angioedema kubonakala phezu kwesikhumba kwaye kubonakala kukukhukhumeza. Ngokuqhelekileyo, kukho umbala obomvu okanye obomvu okanye ukukhawuleza.
- I-Blanching: I-discoloration ebomvu eyenzeka nge-angioedema blanches. I-Blanching ichaza ukutyekela kwesikhumba esichaphazelekayo ukuba sibe yinto ephaphazelekayo imizuzwana embalwa xa ucinezela kuyo uze ubuyele kumbala obomvana okanye obomvu.
Enye indlela yokujonga ukuba wena okanye umntwana wakho u-angioedema kukujonga uluhlu lwezithako zokutya okulungiselelwe ukuba uchithe, ukuba ngaba uqulethe into ethile okanye ilungu losapho olusondeleyo luye lwadlulela kwixesha elidlulileyo.
IiLabs kunye novavanyo
Kukho iintlobo ezimbini eziphambili ze-angioedema-uhlobo lokufa kunye nelifa elingenalo ifa. Izimpawu ziyafana, kodwa iimvavanyo zokuxilonga eziqinisekisa uhlobo ngalunye ziyahlukileyo.
I-Angioedema Ayingenanto
Ngokuqhelekileyo, i-angioedema engenalo ilifa isifo sokuxilongwa ngokusekelwe kovavanyo lwakho lwezonyango, ukuhlolwa kwakho ngokomzimba kunye nokuchongwa kwe-allergen.
I-allergen yiyona nto eyenza i-immune reaction response.
Iimvavanyo eziqhelekileyo ezisetyenziswayo ekuhlolweni kwe-angioedema ziquka:
- Uvavanyo lwe-Allergy Test: Kukho iintlobo ezahlukeneyo zokuvavanya . Into eqhelekileyo ibandakanya isikhumba esincinci sinomlinganiselo omncinci wezinto ezinokubakholelwa ukuba kubangele ukungabikho komzimba. Ukuba unempendulo efana nokubomvu, ukuqhuma, ukuvuvukala, okanye ukubetha kwindawo yokubamba, mhlawumbi unokungabikho komzimba kwi-substance. Unokuvavanywa izinto ezininzi ngelo xesha, kwaye ukuba unempendulo kumntu ongeyena na lo luphawu oluqinileyo lwe-allergies.
- Uvavanyo lwegazi: Iimvavanyo zegazi ziyakwazi ukubona amanqanaba aphakamileyo omsebenzi we-immunological. Ezinye iimpawu zokunyuka komzimba zibandakanya amanqanaba e-white white, i-erythrocyte sedimentation rate (ESR), kunye ne-anti-nuclear antibody (ANA). Zonke ezo, nangona kunjalo, zingabonisa inani lezonyango kunye neengxaki ze-immunological, ngoko azichazi kakuhle kwi-angioedema.
Ngamanye amaxesha, akukho nto ihamba ngayo kwaye i-angioedema ingabakho ukuxilongwa kokukhutshwa emva kwezinye izizathu zeempawu eziye zagqitywa.
I-Angeliedema yaseHereditary
Uvavanyo lofuzo kunye nokuhlolwa kwegazi kunokukwazi ukuchonga le meko. Kuqhelekile ukuba uvavanyo lwegazi.
- Uvavanyo lokuhlola: Uvavanyo lwegazi olulinganisa amanqanaba e-C4 lungasetyenziselwa ukuhlolwa kwegazi nge-angioedema yefa. Amanqanaba aphantsi e-C4 atyhila i-dismune disorder, kwaye izinga eliphantsi liza kubonisa ukuba ufuna enye i-test egazini yegazi ukuze ukhangele ukusilela kwe-C1 inhibitor. Ukuba kukho ubukhulu obuphezulu bokuthi unayo i-angioedema yefa, uza kufuneka ulandelelwe uphando lwegazi lwe-C1 inhibitor deficiency. Kodwa ukuba unethuba elincinane lokuba ne-angioedem yefa, i-C4 eqhelekileyo ibonisa ukuba unayo imeko.
- Uvavanyo lwegazi: Ukuhlolwa kwegazi kubonakalisa i-defect kwi-C1 esterase inhibitor protein (C1-INH). Inqanaba le-C1-INH lingaphantsi kuneqhelekileyo, okanye lingaqhelekile kodwa lingasebenzi. I-C1-INH yiprothini esebenzayo ukugcina isistim somzimba sakho sokuzivikela sihlolisise ukuze singabi sisigxina. Iphutha lokuzalwa ngokwemvelo lidala uhlobo lwangioedema, oluphumela kumazinga aqhelekanga eC1-INH okanye udidi lwe-angioedema, olubangela umsebenzi ongaqhelekanga we-C1-INH.
- Uvavanyo lwe-Genetic: Utshintsho oluthile lwezityalo olwenza ukuba i-angioedema itholakale kwi-SERPING1 geni ngohlobo l kunye ne-angioedema. Ukuguqulwa kwamanzi kwi-F12 i-gene ingaqatshelwa ngohlobo lll angioedema. Isiphumo esicacileyo salesi siqhelo asiqondwa kakuhle.
I-angeliedema ye-Hereditary izuze ifa ngokuqondile kubazali abanomzekelo ophezulu wokuzimela, oko kuthetha ukuba ukuba umntu unayo i-gene ngenxa yale meko, iimpawu zesifo ziya kukhula. Ngenxa yokuba i-autosomal ephezulu, nayiphi na umzali uzuza ilifa le-angioedem hlobo l, lll okanye lll kufuneka nokuba neempawu zalo mqathango kuba luphawu oluphambili. I-angeliedema ye-Hereditary ayiqhelekanga, inokuchaphazela abantu aba-1 kuphela kuma-50,000 abantu.
Uninzi lwexesha, i-angioedema ebangelwa yizifo zengqungquthela ifa kodwa umntu unokuhlakulela ukuguquka komzimba ngokukhawuleza, oku kuthetha ukuba kunokwenzeka ukuhlakulela utshintsho lwezityalo ezenza ukuba imeko ingazange izuze kubazali bakho.
Ukucinga
Ukucinga akuqhelekanga kuncedo ekufumaneni i-angioedema. Kwezinye iimeko, ngokukodwa xa kukho ukuphefumula okufutshane okanye xa iingxaki zesisu ezinjengexinzelelo esiswini, isicupunu, kunye ne-diarrhea ziyingxaki, iimvavanyo zokucinga zengxaki zokulawula ezinye izifo zingadingeka.
Ukuxilongwa ngokungafani
Kukho ezinye iimeko ezinokuthi zivelise iimpawu ezifana nezo ze-angioedema.
Xhumana noDermatitis
Imeko efana ne-angioedema, uxhumano lwe-dermatitis lubangelwa kukuqhagamshelana nenkunkuma eyenza i-hypersensitivity. Iimeko ziyafana kwaye kunokuba nzima ukuchazela umahluko. Uqhagamshelwano lwe-dermatitis aluhambelani nokuvuvukala, kwaye kubangela isikhumba esilukhuni kakhulu, ubomvu, kunye nokukhwabanisa okanye ukukhupha isikhumba.
I-Edema ngenxa yokugula okanye ukulimala
I-Edema ukuvuvukala nayiphi na inxalenye yomzimba. Inokuthi iyenzeka ekuphenduleni ukulimala okanye isifo, apho kwenzeka khona ngokukhawuleza kwaye ngokukhawuleza, kufana ne-edema ye-angioedema.
Njenge-angioedema, i-edema ngenxa yokulimala okanye intsholongwane ingabandakanya kuphela ummandla oqhelile womzimba. Ukhohluko obuqilileyo phakathi kwe-edema, nangona kunjalo, kubandakanywa nomkhuhlane kunye nentlungu enzima xa imbangela yengozi okanye isifo.
Ukungaphumeleli Kwintliziyo okanye Ukungaphumeleli Kwezintso
I-edema yesifo senhliziyo okanye ukungaphumeleli kwezintso kudla ngokuthe gqolo. Uninzi lwexesha, i-edema ayilona uphawu lokuqala lo mqathango.
Iintlukwano ezimbalwa ezibalulekileyo kukuba i-edema yokuhluleka kwentliziyo okanye ukungaphumeleli kwezintso ngokuqhelekileyo kuqhelekileyo, kodwa akufuneki ukuba yimeko ye-angioedema. I-edema ye-angioedema ayilunganga, ngelixa i-edema yesifo senhliziyo okanye ukungaphumeleli kwezintso kubeka i-edema.
I-Vein Deep Thongsis (DVT)
I- DVT ibangela ukuvuvukala komzimba omnye, ngokuqhelekileyo umlenze ophantsi. Njenge-angioedem, kungenokuba ngokukhawuleza, kungenabuhlungu, kunye ne-asymmetric. I-DVT inokubangela i-pulmonary embolism, okubangelwa kukuphefumula okuphefumlelweyo. I-DVT ayikulindeleke ukuba ihambisane nokuvuvukala komlomo okanye amehlo.
Lymphedema
Ukukhusela ukuhamba kwe-fluid kuwo wonke umzimba kungenzeka ngenxa yendlela yokukhusela i-lymphatic system. Oku kuya kwenzeka emva kweentlobo zonyango, ngokukodwa ukuhlinzwa ngomsana.
Amanye amayeza anokuvelisa i- lymphedema . Ngokuqhelekileyo ibonakala ngokuvuvukala ingalo enye kwaye ingabonakaliyo ngaphandle kwembali yonyango ebonisa ukuba i-lymphatic system inobangela.
> Imithombo:
> Bova M, De Feo G, Parente R, et al. I-Heditary and Acquired Angioedema: I-Heterogeneity ye-Pathogenesis ne-Clinical Phenotypes. Int Arch Allergy Immunol. 2018; 175 (3): 126-135. i-doi: 10.1159 / 000486312. Epub 2018 Jan 26.
> Ukukhupha IYI, i-Pritchard N, i-Horný M, i-Xiao CC, i-Brook CD, i-Platt M, i-Inhalant i-sensitization ye-allergenisation iyimfuneko yengozi yokuphuhlisa i-angioedema. NguJ Otolaryngol. Ngo-2018 kuMar-Apr; 39 (2): 111-115. i-doi: 10.1016 / j.amjoto.2017.12.013. Epub 2017 Dec 27.