Ukusetyenziswa kwexesha elide okanye ukusetyenziswa ngokweqile kwi-TB
Iproton pump inhibitors (PPIs) liqela lezilwanyana ezinenjongo yokunciphisa isisu esiswini. Ziye zazisetyenziswa ukuphatha ezininzi izifo ezinxulumene ne-acid esiswini ngaphezu kweminyaka engama-20 kwaye ziyaziwa zikhuselekile kwaye zisebenza-kakhulu kangangokuthi ziye zanyusa i-block block ye-H2 njengezikhethi ezikhethiweyo.
Oku akuthethi ukuba i-PPIs ayinayo imingeni okanye imingeni.
Ngelixa ezininzi iziphumo zempembelelo zinyameko kwaye zilawulwa, zikho iziganeko ezimbi ezinokuthi zenzeke ngokusetyenziswa kwexesha elide okanye ukusetyenziswa kakubi. Ezi zibandakanya iingxaki ngokuxutywa kwamaminerali, utshintsho kwi-bone strength, kunye nobungozi obuninzi bokugula okungapheliyo.
Indlela iProtton Pump Inhibitors isebenza ngayo
Iproton pump inhibitors isetyenziselwa ukuphatha iingxaki ezifana ne- gastroesophageal reflux isifo (GERD) , izilonda ze-peptic , kunye ne- esophagitis eyobuhlungu , oogqirha banokumisela ukusebenzisa i-PPIs yodwa okanye kunye ne-antacids. Zingasetyenziselwa ukudibanisa ne-antibiotiki ezithile xa unyanga i- Helicobacter pylori (ibhaktheriya ngokuqhelekileyo inxulumene nezilonda zamathumbu eziphindaphindiweyo).
Umsebenzi we-PPIs ngokubophelela kwiselula eludongeni lwesisu esibizwa ngokuba yiseli yeparietal enenjongo yokuvelisa i-hydrochloric acid (HCL). Ngokwenza njalo, isisu asinakukwazi ukukhuphela i-HCL, ivumela izilonda ukuba ziphilise kwaye zihlaziye.
Ii-PPI zihluke kwii-block block ze-H2 kwii-PPI zivale iipompu ze-asidi ngelixa i-H2 blockers ikhusela kuphela uphawu olubangele ukuveliswa kwe-asidi. Ngenxa yoko, ii-PPI zisebenza kwiiyure ezingama-24 kwaye zibonelela ukuphucula ukuya kwiiyure ezingama-72. H2 blockers, ngokuphambene, sebenzela iiyure eziyi-12.
Iintlobo ze-Proton Pump Inhibitors
Ngokuqhelekileyo, enye i-PPI ayifani nantoni na into eninzi kwabanye.
Zonke zinendlela ezifanayo zokusebenza kunye namazinga afanayo okusebenza. Okwangoku iiPPs ezivunyiweyo ziquka:
- Prilosec (omeprazole)
- Prevacid (lansoprazole)
- IProsioni (pantoprazole)
- Aciphex (rabeprazole)
- Nexium (esomeprazole)
- Umxhasi (dexlansoprazole)
Nangona ukufana kwazo, ii-PPI ezithile zithathwa ngokugqithiseleyo ekuphatheni iimeko ezithile. Ngokomzekelo, i-Dexilant ne-Protonix ayisetyenziselwa ukuphatha u- H. pylori ukusuleleka; abanye ba. Ukuncedisa ukukhutshwa komlilo, i-Prilosec ne-Prevacid inconywa apho abanye bengabikho. Ngenxa yoko, kubalulekile ukuthetha nodokotela wakho ukuqinisekisa ukuba ukusebenzisa i-PPI kulungile.
Iimpawu eziPhakathi kunye nokuHlangana
Xa kuthathwa ixesha elifutshane, uninzi lweempembelelo ezichaphazelekayo kunye nePP! Ukusetyenziswa kubumnene nangethuba. Eyona nto iqhelekileyo ibandakanya ukutyunjwa, isifo sohudo, ukuguqulwa kwentloko, isisu, isisu esicasulayo, isisulu sokusambisa isisu kunye nokuhlanza.
Ubungqina obandayo bubonisa ukuba ukusetyenziswa kwexesha elide kunokubangela iingxaki ezinzulu. Phakathi kwabo:
- Kuye kucetyiswa ukuba ukusetshenziswa kwe-PPI kunokuphazamisa ukuxutywa kwe-calcium, okukhokelela ekutheni i-bone fracture kwiimeko ezithile. Ephendula, i-US Food and Drug Administration yanikezela izilumkiso ngo-2011 ecebisa ukuba ii-PPI ezingaphezulu kwee-counter should be used for not longer than two weeks on a time to three treatments per year.
- Ukusetyenziswa kwexesha elide lePPI kuye kwadibaniswa nokunyuka kancinci komngcipheko we-pneumonia kunye neClostridium difficile .
- Ucwaningo luye lwabonisa ukuba ukusetyenziswa kwe-PPIs ngaphezu kweminyaka eyi-10 kunomngcipheko we-12.5 weengxowankulu wokuphulukisa isifo esingasasigxina sesifo, esincinci ngaphezu kweepesenti eziyi-8.5 ebonwa ngabantu bonke.
- Uphononongo olufanayo lucetyiswa ukuba abantu abathatha ii-PPIs ngaphezu kweminyaka eyisixhenxe babe neepesenti ezingama-13 zokufumana u-dementia xa kuthelekiswa nabangenalo.
Uninzi lweziphumo ezimbi zibonakala zidibanekile nokuba i-PPIs ayigcini kuphela iipompo ze-acid kwisisu kodwa nakwiminye umzimba, ngokunjalo.
Oku kuquka inxalenye yeseli ebizwa ngokuba yi-lysosome esebenzisa i-asidi ukucima inkunkuma. Ngaphandle kwendlela yokwenza njalo, inkunkuma ingakwazi ukuqokelela kwaye ibangela ukuba iseli ihlasele kwaye ikhule. Le nto inokuthi ilandele ukunyuka okubonakalayo kwizifundo.
Ezi ziphumo zigqamisa ukuba i-PPIs kufuneka isetyenziswe kuphela kwixesha elifutshane uncedo okanye unyango kunokuba luncedo lokuthintela izifo zesigxina kwixesha elide.
> Umthombo
- > Jacob Schoenfeld, J. noGrady, D. "Imiphumo emibi ehambelana neProton Pump Inhibitors." Umbhalo we-American Medical Association. 2016: 176 (2): 172-174.