I-hormone ye-antidiuretic, okanye i-ADH, ihomoni evelisa kwi-hypothalamus kwaye ikhutshwe yi-pituitary gland. Umsebenzi oyintloko kukuba kugcinwe uxinzelelo lwegazi, umthambo wegazi kunye namanqanaba emithambo yamanzi.
Abasetyhini abane- polycystic ovarian syndrome , okanye i-PCOS, basengozini yokuxinzelelo lwegazi kwaye banokungalingani kwe-ADH.
Eyaziwa nangokuthi i-vasopressin, i-ADH ikhuthaza ukuphambana komzimba kunye nokubangela ukuba umzimba ugcine amanzi, uncedise ukuthintela ukungcola.
I-secretion ye-ADH isebenze xa iiseli ezikhethekileyo kwingqondo okanye intliziyo zibona utshintsho kwiinkcaso zegazi okanye uxinzelelo lwegazi.
Emva kokukhululwa, i-ADH iya kwiintliziyo apho ibonakalise iiseli ezithile ukuba zibuyisele kwakhona amanzi emvini ezigcinwe ezintsheni, ukukhusela amanzi ekulahlekeni ngokucoca. Oku kwandisa zombini igazi nomfutho wegazi.
IiNqanaba zeAADH ezongeziweyo
Amanqanaba aphezulu e-ADH angabangela ukugcinwa kwamanzi. Imeko eyaziwa ngokuba yiSyndrome ye-Hormone ye-Hormone ye-Anti-Diuretic ye-Hormone engafanelekanga (i-SIADH) ivelisa i-ADH engaphezulu ukuba ikhutshwe xa ingafunwa.
Amanqanaba e-ADH aphezulu kakhulu angaba yiphumelelwano lamacandelo athile, okanye kubangelwa isifo okanye isisu kumaphaphu, hypothalamus okanye pituitary gland.
Ukusela utywala, ngakolunye uhlangothi, kukuvimbela ukukhululwa kwe-ADH, okubangele ukwanda kwendlela yokuvelisa umchamo kunye nokukhulelwa kwamanzi.
Iimpawu zokungalingani kwe-ADH ziquka ukuncwina, ukuhlanza, izihlunu ze-muscle, ukudideka kunye nokudibanisa.
Uvavanyo lwe-ADH
Ugqirha wakho unokuyalela uvavanyo lwe-ADH xa ufumana unxanxu olunzulu, ukucoca rhoqo okanye ukuphelelwa amanzi , okanye unamazinga e-sodium engavamile. Uvavanyo lukwabizwa ngokuba yi-AVP okanye i-arginine vasopressin.
Ukufumana umlinganiselo ochanekileyo we-ADH, nangona kunjalo, inokuba yinto ekhohlisayo, kuba i-molecule encinci kunye nobomi obufutshane.
Ngamanye amaxesha oogqirha basebenzisa i-copeptin njenge-ADH. I-Copeptin iye yadibaniswa ne- atherosclerosis kunye nesifo senhliziyo, kwaye isenokusetyenziswa ukuchonga ukuhlaselwa kwentliziyo kwinqanaba lokuqala.
ADH kunye neengqondo zeNtliziyo
Uphando olutshanje olupapashwe kwiNcwadi yoPhando lwe-Ovariya lufumene amanqanaba aphakamileyo e-copeptin adlala indima ebalulekileyo kwimpendulo ye-metabolic kunye nophuhliso lwe-atherosclerosis kwi- insulin engaxhatshazwayo , abesetyhini abangama-hyperandrogenemic ne-PCOS.
Olunye uphando olutholekileyo, kwabasetyhini abane-PCOS, amanqanaba e-copeptin aphezulu kwizigulane ezigqithiseleyo kunezo ziko eziqhelekileyo, kwaye zicebisa ukuvavanya ukuhlolwa kweengxaki ze-cardiovascular in patients.
Imithombo:
Karbek B, Ozbek M, Karakose M, et al. I-Copeptin, ummakishi oyisigxina se-arginine vasopressin, uxutywa ngumngcipheko we-cardiovascular in patients kwi-polycystic ovary syndrome. J Ovarian Res . 2014 uMatshi 14; 7:31. I-doi: 10.1186 / 1757-2215-7-31.
I-Taskin MI, i-Bulbul E, i-Adali E, i-Hismiogullari AA, i-Inceboz U. Amanqanaba okujikeleza obestatin kwaye aphethwe ngabesifazane abagqithisileyo nabangabikhoyo kunye ne-polycystic ovary syndrome. I-Eur J I-Obstet Gynecol ihlawula i-Biol . 2015 Juni; 189: 19-23. i-doi: 10.1016 / j.ejogrb.2015.03.006.