UBenfotiamine yindlela eyenziwe ngumntu we-thiamine okanye i-B1. I-thiamine i-vitamin e-soluble yamanzi kwaye ngoko ingasetyenziswe ngokulula ngumzimba. I-Benfotiamine yenziwe yincithakalo etyebileyo kwaye ilungele ngakumbi kwaye isetyenziswe. Kukho ubungqina bokuba i-benfotiamine inokunceda ukukhulula ubunzima besifo sesifo sikashukela ezifana ne-retinopathy, nephropathy, kunye neuropathy.
Benfotiamine kwi-Diabetes Neuropathy
UBenfotiamine uye wafumana izifundo eziliqela kwiminyaka yamuva. Ingqwalasela ephambili yezifundo ziquka ukusebenzisa i-benfotiamine njengonyango lweengxaki zesifo sikashukela.
Uninzi lweengxaki zesifo sikashukela kubangelwa yi-hyperglycemia ende (i-sugar high blood sugar) ngenxa ye-glucose yegazi engalawulwayo okanye ukuqhubela izifo ngexesha. I-glucose engaphezu kwegazi ifakwa kwiiseli zesiswini kunye nemithambo encinci yegazi kwimida, kubangela ukulimala kule mimandla ebangela iimpawu kunye neempawu zeengxaki.
Iindlela eziNye eziMonakalo zelungu
Kukho iindlela ezine ezihlukeneyo ezenzeka emzimbeni onokukhokelela kumonakalo omncinci wamanzi ngenxa ye-hyperglycemia kwisifo sikashukela.
- Iiprogram zokugqibela ze-glycation (AGE)
- Iprotheni kinase C (PKC)
- I-Hexosamine indlela yokusebenza
- Ukusetyenziswa kwePolol endleleni
I-Benfotiamine ibonakala ivimbela ezintathu zale ndlela kwizifundo zonyango. I-athikili, eyavela kwiphephancwadi ye-Nature Medicine ngoFebruwari 2003, ebizwa ngokuthi "i-Benfotiamine Blocks Three Ways Road of Damage and Hyperglycemic Damage" kwaye ibonisa ukuba i-benfotiamine yathintela ukuthinteka kwesifo sikashukela kwizilwanyana zasebhoratri.
Imveliso yokuGlycation End Endle
I-Hyperglycemia ibangela umonakalo emithanjeni yegazi kunye nemisipha yomzimba, leyo eya kuba yinkxalabo enkulu yesifo sikashukela. Imonakalo yenzeka xa i-glucose engaphezu kwegazi ihlala kwiiseli kwaye yenza i-substance eyaziwa njenge-advanced glycation endproducts (AGE). I-AGE ifumaneka kwiinqanawa zamehlo, iintso kunye nemida. Zifumaneka nakwezinye iinqanawa ezinkulu zegazi kwaye zikhokelela ekuvelweni kweplate kunye ne-atherosclerosis, eyinxaxheba kwizifo zentliziyo.
Yintoni uBenfotiamine Eyenzayo
Izifundo zibonise ukuba i-benfotiamine ibonakala inokunceda ukukhusela iingxaki ze-neuropathy, i-retinopathy, ne-nephropathy ngokuvimbela ukwakhiwa kwe-glucose kwiinqanawa. Oku kuthetha ukuba ukuvela kweengxaki zesifo sikashukela kunokunciphisa okanye kuthintelwe. Ucwaningo lwekliniki oluvela kwiphepha le-ADA leSabetes ngo-2003 lubonise ukuba i-thiamine ye-high-dose ne-benfotiamine ibonakala ithintela i-microalbuminuria kunye neproteinuria (iiprotheyini kumchamo) kwiiratshi zesifo sikashukela. Izifundo ezenzelwe abantu zibonise ukuba i-benfotiamine ibonakala iphinde ikhulule ubuhlungu be-neuropathic.
Imeko yangoku yeBenfotiamine
I-Benfotiamine isesegabeni lesilingo sesilingo. Ezi zifundo ziye zenziwa kwiirats eziye zanyanzelwa ukuba zibe nesifo sikashukela.
Izilingo ezininzi zifunekayo ukuchonga ukuba i-benfotiamine isebenza ngendlela efanayo kubantu abanesifo sikashukela. Izinga eliphumelelayo alisayi kusekwa, kwaye iziphumo ezibi zangexesha elide aziwazanga.
Nangona i-benfotiamine ayikhuthazwa ngokusemthethweni ngabaqeqeshi bezeMpilo eMelika ngeli xesha, kubonakala ngathi ingaba yonyango ethembisayo yesifo sikashukela phantsi kwendlela.
Ukuvunyelwa kusalindelekile yi-FDA
Ulawulo lwezoKutya kunye noLawulo lweMithi (FDA) alukaze luvume i-benfotiamine ukusetyenziswa koluntu. Kukho iingxabano malunga nendlela le mali kufuneka ibhalwe ngayo, ingaba isongezelelo sokutya okanye i-vitamin.
Kukho iinkxalabo malunga nokukhuseleka kwexesha elide lokusebenzisa i-benfotiamine kwaye yintoni eyenza umlinganiselo okhuselekileyo. I-FDA idinga ubungqina obuninzi bokuthi i-benfotiamine ivelisa iziphumo ezibonwe kwizilingo.
Kunyaka ophelileyo, i-benfotiamine yangeniswa kwi-FDA njengesongezelelo sesondlo, kodwa ukuvunywa kulindele ngeli xesha.
- I-FDA I-Response Letter ekuhanjisweni kweBenfotiamine njengeNcediso yeZidlo
Imithombo:
> Hamba, E., uLederman H., Kopcke W. "UBenfotiamine kwiNyango yeSifo seSifo seSifo seSifo seSyibineli-Iveki eZiThathu eziLungelelweyo, iSifundo soPhando esiLawulayo." I-International Journal ye-Clinical Pharmacology, unyango kunye neTyxicology Jun 2005: 304. PubMed.gov. ILayibrari kaZwelonke yeMicandelo kunye namaZiko eZiko lezeMpilo. 09 uMatshi 2007.
> Huebschmann, MD, Amy G., Regensteiner, Ph.D., uJudith G., Vlassara, MD, uHelen, kunye noReusch, MD, uJane EB "I-Diabetes ne-Advanced Glycoxidation-Products-End". Uncedo lweSwekile luka-2006 1420-1432. 09 uMatshi 2007.
> Melpomemi >, MD, uPeppa, Uribarri, MD, Jaime, kunye noVlassara, MD, uHelen. "I-Glucose, iMveliso yokuGlycation End Endle, kunye neSifo seSifo seSabetes: Yintoni entsha kunye neyayisebenzayo." Isifo sikashukela sika-2003 186-187. 09 uMatshi 2007.
> I-TB, MD, i-Alin, i-Negrean, MD, i-Monica, i-Stratmann, > PHD >, i-Bernd, iGawlowski, i-MS, uTomas, iHorstmann, i-Tina, > Ukufumana >, > PHD >, i-Christian, i-Kleesiek, i-MD, i-Knut, i-Mueller-i-Roesel , MD, Micheela, Koschinsky, MD, Theodor, Uribarri, MD, Jaime, Vlassara, MD, uHelen noTschoepe, MD, Diethelm, "UBenfotiamine iVimbela iMicro-and Microvascular Endothelial Ukungasebenzi kunye nokuxinezeleka koxinzelelo emva kokutya okucebileyo kwi-Advanced Glycation End Products KuBantu ngabanye abane-Type 2 Diabetes. " Unonophelo lweSwekile 2006 2064-2071. 13 uMatshi 2007.
> "Izidakamizwa Ukujongana Neengxaki." Ukusuka kuphando ukuya kwiNyaniso. 2005. I-Youth's Diabetes Research Foundation International. 18 uMatshi 2007.
> Hammes, Hans-Peter, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. "I-Benfotiamine Blocks Iindlela Ezinkulu Ezininzi Zokulimala Kwama-Hyperglycemic and Prevents Retinopathy". Uhlobo lweMithi, 18 Feb. 2003 294-299. 18 uMatshi 2007.