Iibhanki eziqhelekileyo kunye noko kuthetha
Ngaphambi kokuba ufumane i- neoplasm ye-myeloproliferative ungayidingi imfuneko yegazi, mhlawumbi kanye ngonyaka ngokuhlolwa kwakho kwenyama. Ngoku ungase uzibuze-yintoni le yonke legazi? Yintoni ugqirha ndikhangele? Yonke imisebenzi yegazi enokuthi iyalwe yinto engaphezulu koko sinokuyijonga apha, kodwa makhe sijonge kwizinto eziqhelekileyo.
Gcwalisa iAgazi yeGazi (iCBC)
I- CBC yenye yeyona ndlela eqhelekileyo yomsebenzi webhu ebesebenzisa ukujongana neengxaki zegazi.
I-CBC ihlolisisa iiseli zegazi lakho: iiseli zegazi ezimhlophe, iiseli ezibomvu zegazi kunye neeplatelet. Olu vavanyo kaninzi luyinqaku lokuqala kwizinto ezibangela iimpawu zakho, luyinxalenye yesigxina somsebenzi wokuxilonga, kwaye unokutsalwa rhoqo ngexesha lotyando.
Iiseli zegazi ezimhlophe (WBC) ziyinxenye yesistim sakho sokuzivikela kunye nokunceda ukulwa nezifo. Kukho iintlobo ezi-5 ze- WBCs : i-neutrophils, i-lymphocytes, i-monocytes, i-eosinophil, kunye ne-basophil. Inani le-WBCs kwigazi lakho liqhelekileyo inani lokuqala elibikwe kwiCBC. Icandelo le-CBC, elibizwa ngokuba lihluke okanye lihluke, lijonga ukuba yeyiphi ipesenteji nganye ye-WBC ekhoyo.
Kwi-polycythemia vera ( PV ) okanye i-thrombocythemia ebalulekileyo ( ET ), inani lakho le-WBC linokuphakanyiswa kancinci (leukocytosis). Kwi-primary myelofibrosis ( PMF ), abanye abantu abanokuphakamisa inani le-WBC, elithile eliqhelekileyo, kanti abanye baya kuba ne-WBC count ephantsi (leukopenia).
Iiseli zegazi ezibomvu (RBC) zithwala i-oksijini emiphakeni ukuya kwizitho.
Kukho iindlela ezininzi zokujonga iiseli ezibomvu zegazi kwiCBC. Okokuqala, i- RBC count inani leeseli ezibomvu zegazi. I-Hemoglobin iprotheni efumaneka kwi-RBC ephethe i-oxygen. I-Hematocrit ibonisa ukuba likhulu kangakanani igazi elenziwe ngama-RBC (xa kuthelekiswa neWBC kunye neeplatelets).
Kwiemeko ezibangela inani elongezelelweyo le-RBC, njenge-polycythemia vera, i-hemoglobin ne-hematocrit ziphakanyisiwe. I-hematocrit isetyenziselwa ukujonga ukuphumelela kwonyango kwi-PV. Amachiza kunye ne- phlebotomy (ukususwa ngokomzimba kwegazi) zihlengahlengiswa kwisiseko se-hematocrit (ngokuqhelekileyo ngaphantsi kwama-45 ekhulwini kumadoda kwaye ngaphantsi kwama-42 ekhulwini kwabasetyhini).
Kwi-PMF, izinga lakho le-hemoglobin liyinxalenye yolu hlobo olusetyenziselwa ukucacisa amanqaku akho okuxela. Oku kungatshintsha ngexesha lokugula kwakho. I-hemoglobin engaphantsi kwama-10 amagremu ngamnye kwi-deciliter (g / dL) kwisiseko, ibalwa njengamaphuzu amabini kumanqaku okuxela (amanqaku angaphezulu afana nesifo esilinganayo). Ingasetyenziselwa ukuchonga ukuba ufuna ukunyelwa igazi.
Ukuxilongwa kwegazi kunikezwa xa i-hemoglobin ihlahla ngaphantsi kweesibhozo ezisibhozo kwi-deciliter nganye okanye ukuba uyimpawu (ukukhathala, utywala, inqanaba lentliziyo ephakamileyo). Ukufuna ukumpontshelwa kwongezwa ingongoma eyongezelelweyo kumanqaku okuxela.
Inani lePlatelet likwabandakanywa kwiCBC. Efana ne-hematocrit kwi-PV, kubantu abane-ET abafuna unyango, isibalo seplatelet sisetyenziselwa ukulungelelanisa unyango olusekelwe kwinqanaba leplatelet elifunwayo. Kwi-PMF, i-platelet ibalwa ngaphantsi kwama-100,000 amaseli nganye nge-microliter inezela enye ingongoma kumlinganiselo wakho wokuxela.
Igazi leSmear
I-ET kunye ne-PV inokuguquka kwi-myelofibrosis kunye ne-leukemia, iimpawu zokuqala zolu tshintsho zingabonwa kwi-CBC, ngokukodwa ukulahla okukhulu kwi-hemoglobin kunye ne-platelet count. Iseli legazi elibomvu kunye neplatelet yenziwe ngendlela engavumelekanga kwi-myelofibrosis engabonwa kwi-smear yegazi (i-microdicope slide yeeseli zegazi).
von Willebrand Panel
Abantu abane-ET basengozini yokuphuhlisa isifo se-von Willebrand, ukuphazamiseka kwegazi. Lo mngcipheko uya kunyuka njengoko isibalo seplatelet senyuka (ngaphezulu kwesigidi seeplatelet nge microliter). Ukuba unayo i-ET kunye nokuphaphaza, iphaneli ye-von Willebrand ingathunyelwa ukucacisa ukuba ngaba le nto ibangela.
Unyango uyanciphisa inani leplatelet.
Xa ufumana umsebenzi wegazi rhoqo, kunokukhathazeka kwaye kunzima ukubona isizathu. Xoxa ngale nkxalabo ngogqirha wakho ukuze nonke nibe kwiphepha elifanayo.
> Umthombo:
> I-Teferri A. Iprognosis kunye noPiliso lwe-Essential Thrombocythemia, ukuxhamla kwe-Primary Myelofibrosis kunye noLawulo lwe-Primary Myelofibrosis, kunye nePrognosis kunye nokuPhathwa kwe-Polycythemia Vera. Ku: U-UpToDate, i-Post TW (Ed), UpToDate, i-Waltham, MA. 2016.