Unomdlavuza webele we-medullary uhluke njani kwezinye iisomhlaza zebele?
I-Medullary carcinoma yesifuba isimo esingavamile somdlavuza webele. Luhlobo lwe- ductal carcinoma (IDC) kwaye lithatha igama ukusuka kumbala walo, osondele kumbala weethambo zesisu, okanye i-medulla. Iqala kwimibhobho yobisi, kunye neeseli ezinkulu zomhlaza ezibukeka zihluke kakhulu kwiiseli eziphilileyo.
I-Medullary carcinoma ayikho isifo esichengileyo.
I-Medullary carcinoma yenza iipesenti ezi-3 kuphela ukuya kwi-5 ekhulwini yazo zonke i-cancer. Kungaba nzima ukuhlula kwi-carcinoma ye-ductal engenawo kwaye kukho ezinye i-cancer ezizinto ezithile kodwa azikho zonke iimpawu ze-medullary carcinoma. Ngenxa yoko, oogqirha maxa wambi baphatha i-carloma engumlomo ngokugqithiseleyo, mhlawumbi, kunokuba kunyanzelekile, kunikezelwa kakuhle. Kuqhelekileyo kubasetyhini ekupheleni kwama-40 kunye nama-50s okuqala.
Kubonakala
Amaseli e-Medullary i-carcinoma athambekele ekubeni ngumda ocacileyo phakathi kwe-tumor kunye nezicubu ezinempilo ezikufutshane nazo-zingenasiphelo ezincinci kunezinye iiseli zomhlaza zesifuba. Ngaphantsi kwe-microscope, iiseli zikhulu kwaye zingabonakali ngokungaqhelekanga kwaye zibuhlungu, kodwa zithemba ukuba zingabi nonyala njengoko zibukeka.
Ngamaxesha amaninzi amaninzi omzimba (njengemilenze ye-lymphocytes) kwimida yee-tumors, ebonisa ukuba isistim somzimba sisebenzela ukulwa nesisu.
Xa umdlavuza webele usenokubonakala kwe-medullary carcinoma kodwa awufanelanga yonke imilinganiselo, unokuva isifo sakho esibizwa ngokuthi "i-medicular medullary carcinoma". Ezi khansela ze-atypical zihlala ziphathwa kangangoko zifana nezinye i-cancer zebele, ngamanye amagama, ngokugqithiseleyo.
Izimpawu kunye neMpawu
I-Medullary carcinoma yesifuba ayinakuhlala ivakalelwa njengengcambu, kodwa kunoko, njengendawo enesibindi, indawo esele i-spongy ye-tissue.
Okokuqala kunokuqatshelwa njengentlungu, ubomvu, okanye ukuvuvukala esiswini sakho. Ekubeni iiseli ze-medullary carcinoma zikhulu kwaye zivame ukuhlala kunye kunye nokwandisa kwindawo enye, i-tumor ingavakalelwa yinto epholileyo, njenge- cyst . Esi sizathu esinye sokuba kubaluleke kakhulu ukuba naluphi na uhla lwebhokhwe lwakho oluhlolisisiweyo, nokuba luba ngathi lufana ne-cyst elula.
Uvavanyo lweSifo
I-Medullary cancer yamabele ayibonakali rhoqo kwi-mammogram kwaye idla ngokuqala xa umntu evakalelwa. I- breast ultrasound ingenziwa kwakhona. Indlela yodwa yokwahlula i-medullary carcinoma evela kwezinye iifom zesifo somhlaza ngumbele nge-biopsy. Isampuli yesisithwa sidla ngokubanjwa ngokuvuleka okuvulekileyo okanye ngesifo se-stereotactic .
Unyango
Uninzi lwe-medullary carcinomas lincinci kwaye lunokuphathwa lula ngokuhlinzwa. Akunamathuba amaninzi kunamanye amachiza okusabalala ukuba asasaze kwii-lymph nodes, kwaye oogqirha abathile bajonga ukuba ukuhlinzwa kuphela yinto yokwanela unyango lwezi zihlamba (ezininzi zazo zingaphantsi kwe-intshi enye ubukhulu.) Unyango lunokubandakanya:
- Ugqirha : Unyango olwenziwa ngabantu abaninzi banalo hlobo lomhlaza wesifuba kwaye lunokuba lumpectomy okanye i- mastectomy , ngokuxhomekeka kwindawo yesikhumba kunye nezinto ezithandayo.
- I-Chemotherapy : Njengoko ininzi yalezi zicubu zincinci kwaye aziqhelanga ngokukhawuleza kwi-lymph nodes, i-chemotherapy idla ngokufunekayo ukuba i-tumors ikhudlwana kune-intshi ngobukhulu. Oko kwathiwa, ezininzi zalezi zicubu zihamba-ziphethe iimpawu - zezinye iintlobo zesifo somhlaza wesifuba, ngoko ke unokuphathwa kakubi.
- Ukunyanga kwamayeza : Kwakhona, unyango lwe-radiation lusetyenziswa kangangoko kunokuba lube nolunye uhlobo lwesifo somhlaza webele, kodwa lunokusetyenziswa kwiimeko ezithile.
- I-hormone yokwelapha : I- hormone yokwelapha isetyenziswe kaninzi nge-medullary carcinoma, eninzi kwezi zicubu ziyi-hormone receptor negative. Kwisifundo esinye, i-68% yalezi zicubu zangezona ziphumo ze-estrogen receptors kunye neepesenti ezingama-86 zazingenakulungele ukufumana i-progesterone receptors.
- I-Herceptin isetyenziswe ngokungafanekiyo nale hlobo lomhlaza njengoko ezininzi zezi zicuba zi-HER2 ezingalunganga. Kwisifundo esinye ngaphezu kwama-80 ekhulwini kweemvumi zazingalunganga kwi-HER2 receptors.
Prognosis
I-Medullary carcinoma iba neeklasi eziphezulu ezibonakalayo zisebenza ngendlela ekhulayo. Akunakwenzeka ukuba asasaze kwii-lymph nodes kunezinye i-cancer zebele kunye ne-overall isifo esilungileyo. Kwesifundo esisodwa esikhulu, izinga lokusinda kwi-2 leminyaka lalingama-98.2 ekhulwini. Izinga lokuphindaphinda ngaphaya kweli libuye liphantsi kakhulu xa kuthelekiswa nezinye iintlobo zomhlaza wesibele.
Imithombo:
Chu, Z., Lin, H., Liang, X., Huang, R., Zhan, Q., Jiang, J., kunye no X. Zhou. Iziganeko zeCliniki ze-epathologic ze-medullary breast carcinoma: ukufundwa ngokuphindaphindiweyo kwamatyala angama-117. PLos One . 2014. 9 (11): e111493.
Dieci, M., Orvieto, E., Dominici, M., Conte, P., kunye no-V. Guarneri. I-subtypes yomhlaza wesifuba esiswini: i-histological, i-molecular, kunye neenkcukacha zeklinikhi. Oncologist . 2014. 19 (8): 805-13.
Lim, S., Park, S., Park, H., Hur, M, Oh, S., noY. Suh. Iprognostic Indima ye-Adjuvant Chemotherapy kwi-Node-Negative (NO), i-Triple-Negative (TN), i-Medullary Breast Cancer (MBC) kwi-Korean Population. PLos One . 2015. 10 (11): e0140208.
Shokouh, T., Eztollah, A., noP. Barand. Intsebenziswano phakathi kwe-Ki67, i-HER2 / neu, i-p53, i-ER kunye ne-PR Status kunye neNxulumano yabo kunye ne-Tumor Grade kunye nokubandakanya i-Lymph Node kwi-Breast Carcinoma Subtypes: I-Retrospective-Observational Study Analysis. Mayeza . 2015. 94 (3): e1359.