Iziphumo zokuQala kwiZiyobisi ezijolise kwiCGRP kunye neReceptor yayo
I-peptide ehlobene ne-Calcitonin ye-gene (i-CGRP), iprotheni eveliswe ngamanye amaseli enesistim kwiinkqubo zesantya esisiseko kunye nenkqubo yesifo senzondo, ikholelwa ukuba ibamba indima ebalulekileyo kwimigraines. Akunalo nje kuphela le protein efunyenwe ukuba iphakanyiswe ngexesha lokuhlaselwa kwe-migraine, kodwa ukunciphisa intlungu ye-migraine kunye neyeza elithatha i-migraine elibizwa ngokuba yi- triptan lihambelane ne-normalization yezinga le-CGRP kwigazi.
Ngethuba lokuhlaselwa kwe-migraine, kunokwenzeka ukuba ezinye iintshukumo ze-migraine zivuselela imilambo yegazi ejikeleze ingqondo ukuba ihluthe, okanye ikhulise. Ezi mjelo zegazi ezixubileyo zize zisebenzise iimbilini ze-nergeminal sensory fibers. Xa sele kusebenze, iimbombo ze-nerve ze-trigeminal zithumela impendulo kwintlungu-eyenza ukukhutshwa kweeprotheni ezahlukeneyo, njengeCGRP.
I-CGRP ke ibangela ukuhluthwa okuqhubekayo kwemithambo yegazi kunye nezinto ezibizwa ngokuthi "ukuvutha kwe-neurogenic". Njengoko ukuhlaselwa kwe-migraine kuqhubela phambili, i-brainstem iyancipha. Oku kukhokelela kumjikelezo onobuhlungu wentlungu kunye nentlungu ephakamileyo kwindawo.
Ziziphi izifundo zokuQala kwi-CGRP Show?
Izifundo II zeSigaba II - uphando olwenziwa kwincinci elincinci yezigulane ukufumana inzuzo kunye nemiphumo emibi yechiza - ngoku ukuthembisa ukuba i-CGRP yamanqindi aphephe i-migraines kwaye iyakunyamezeleka.
Kwisifundo esithile, abathathi-nxaxheba abangama-217 abanamava angama-4 ukuya kwe-14 abamba inyanga, babengabonakali ngokungaqhelekanga ukuba bafumane ngaphantsi kwesikhumba seentsuku kabini kwiveki ebizwa ngokuba yi-LY2951742 okanye indawo ye-placebo-ishukela okanye i-injection yamanzi - iiveki ezili-12.
(LY2951742 yi-antibody kwi-peptide ehlobene ne-calcitonin ye-gene (i-CGRP) - oku kuthetha ukuba ibophezela kwi-CGRP kwaye ibinqatshelwe okanye ayisebenzise).
Iziphumo zacetyiswa ukuba abathathi-nxaxheba abathole i-LY2951742 banokunciphisa kakhulu kwinani leentsuku zentloko ze-migraine xa kuthelekiswa ne-placebo. Iindaba ezilungileyo kukuba le nkunkuma ifunyenwe ikhuselekile kwaye ibekezeleke kakuhle zezifundo.
Oko kuthetha ukuba iziphumo ezimbi zibandakanya:
- intlungu yentlungu
- intlungu zesisu
- isifo sokuphefumula esiphezulu (isib. i-bronchitis)
Esinye isilwanyana esibizwa ngokuba yi-ALD403 - kunye ne-calcitonin-ehlobene ne-peptide-antibody-yahlolwa kwi-163 abathathi-nxaxheba abanama-5 ukuya kwe-14 abafudula inyanga. Isiqingatha sezifundo ezifunyenwe ngumbono ongu-1000mg (intlavenous) ngesifo semithi, ngelixa esinye isiqingatha sifumana i-placebo. Izifundo zalandelwa iinyanga ezintandathu.
Ngeeveki ezi-5 ukuya kwe-8, abathathi-nxaxheba abafumana iziyobisi babone ukunciphisa ama-66 ekhulwini kwinani leentsuku abahluphekileyo ukusuka kwi-migraine kuya kuma-52 ekhulwini kulabo abafumana indawo ye-placebo.
Kwakhona, kwiiveki ezili-12, iipesenti ezili-16 zezigulane ezamkelekileyo izidakamizwa zazingenakufudumala ngaphandle kwemigudu yazo kwalabo bafumana i-placebo.
Ekugqibeleni, esinye isilwanyana, esilawulwa phantsi kwesikhumba (i-injection subcutaneous) ebizwa ngokuthi i-AMG 334-isifo sokulwa nomntu obopha kwi-CGRP kwi-site ye-CGRP)-isandul 'ukufunyanwa ukukhusela i-migraines ngokunjalo. Njengamanye amabini amachiza, i-AMG 334 yayinyamezelekile. Iimpembelelo eziqhelekileyo eziqhelekileyo zi:
- iimpawu ezibandayo
- ukukhathala
- intloko okanye i-migraine (iya kufanana - encinci, iipesenti ezi-3 ukuya kuma-1 ekhulwini kwiqela le-placebo)
- isicaphulelo
- isifo sokuphefumula esiphezulu (isib. i-bronchitis).
Ngaphantsi
Ezi ziyimiphumo ebangelisayo kwimimandla ye-migraine. Nangona kunjalo, uphando oluninzi lwesifundo se-III lukhulu kwaye luqinisekisa ubungqina bezifundo zesigaba II - kufuneka kwenziwe phambi kokuba ezi ziyobisi zifumaneke kwizigulane.
Imithombo:
Bigal ME, Walter S, Rapport AM. I-Calcitonin i-peptide i-peptide (CGRP) kunye ne-migraine ukuqonda kwangoku kunye nomhlaba wophuhliso. Intloko . 2013; 53 (8): 1230-44.
IDrayham PL. I-Calcitonin-Related Related Peptide (CGRP) kunye ne-Migraine. Intloko. 2006; 46 (iSiza 1): S3-S8.
I-Goadsby PJ, no-Edvinsson L. Inkqubo ye-trigeminovascular kunye ne-migraine: izifundo ezibonisa ukuguqulwa kwe-cerebrovascular kunye neuropeptiptide ebonwa ngabantu kunye neekati. Ann Neurol. Ngo-1993 uJan; 33 (1): 48-56.
Iziphumo zokuqala ze-ALD403, i-Medicine entsha yoPhando kwi-Migraine Prevention. (nd). E-American Headache Society. Ibuyiswe ngoMeyi 18, 2014.
Sun H et al. Ukukhusela nokusebenza kwe-AMG 334 ngokuthintela i-epradic migraine: i-random, i-double-blind, i-placebo-elawulwayo, isigaba sesivivinyo sesi-2. Lancet Neurol. 2016; 15 (4): 382-90.