I-HER2 , ebizwa ngokuba yi-HER2 / neu kunye ne-HER-2, isingqamaniso sokwakheka kwe-epidermal yokufumana i-factor receptor 2. Ukwazi isimo sakho se-HER2 yingxenye ebalulekileyo yokuxilongwa kwakho.
I-HER2 ngumgubo okhokelela kwiprotheyini ekhoyo phezu kwamaseli. Iseli lesifuba enempilo inekopi ezimbini ze-HER2. Kwingaba malunga neepesenti ezingama-30 zomhlaza webele, iseli zomhlaza zesifuba zinemifanekiso engaphezu kwembini yaloo mfuza, kwaye oku kukhokelela ekuveleni kweprotheni ye-HER2.
Ngenxa yoko, iiseli ezichaphazelekayo zikhula kwaye zahlula kakhulu ngokukhawuleza.
Ukubonakaliswa kwangaphambili okanye ukukhuliswa kwe-gene HER2 kuboniswe ukuba badlale indima ebalulekileyo ekuphuhlisweni nasekuqhubekeni kweentlobo ezithile zesifo somhlaza kunye nezinye iintlobo zomhlaza.
Ngaba Ifa?
Le ngxaki yezofuzo ayizuze ilifa kubazali bakho. Ukungaqhelekanga kwesi sifo kuhambelana nenkqubo yomhlaza.
Iziphumo ezintle kunye neziphumo zokuvavanya
Ukuba umhlaza wakho webele uvivinywa ngesimo se-H22, iziphumo ziya kubalwa njengezinto ezilungileyo okanye ezingalunganga. Ukuba iziphumo zakho zifakwe njenge-HER2 positive, oko kuthetha ukuba iigeri zakho ze-HER2 zenze ngaphezu kwe-HER2 protein. Ukuba iziphumo zakho zihlawulelwe i-HER2 engalunganga, ii-gene ze-HER2 azikhuliswa.
Ufumane unyango
I-Herceptin (i-trastuzumab) isilwanyana esetyenziswa ngoku ukuphatha umdlavuza webele we-HER2. Ingonyango ekujoliswe kuyo kwaye iphinda ibhekiswe njengonyango lokukhusela umzimba.
Esi sidakamizwa siya kunikwa kwangaphakathi, kanye emva kweeveki ezimbini ukuya kwiiveki ezintathu. Xa sele kusekhompyutheni yakho, u-Herceptin ujolise iiprotheni ze-HER2 ezikhoyo kwinani elingaphezulu kweeseli zomhlaza zesifuba. Oku kunceda ukumisa ukukhula kwee-HER2 zentsholongwane zesifo somhlaza.
Ezinye iziphumo zonyango likaHerceptin ziquka:
- iyancipha i-HER2 izicubu ezintle, phambi kokuhlinzwa
- ulahla i-HER2 yesifo somhlaza esele sichitha ngaphaya kwe-tumor yangempela.
- Inceda ukukhusela ukuphindaphinda (ukubuya) komhlaza weHER2 omuhle
Uvavanyo lweHER2
Ugqirha wakho unokubiza iimvavanyo ezimbalwa:
- I-FISH: I-Fluorescence In Hybridation Situation-olu vavanyo lusebenzisa i-projekthi ye-fluorescent ukujonga inani leikopi ze-HER2 kwi-cell cell. Ukuba kukho iikopi ezingaphezu kweebini zegridi ye-HER2, ngoko umhlaza ngumHER2 ochanekileyo.
- I-IHC: i-ImmunoHistoChemistry-olu vavanyo lusetyenzisela ukuveliswa kweprotheni ye-HER2 yi-tumor. Iziphumo zovavanyo zibalwa njenge-0, 1+, 2+, okanye i-3+. Ukuba iziphumo zi-3+, umhlaza wakho u-HER2-positive. Ukuba iziphumo zi-2+, uya kufuna iimvavanyo ze-FISH ukuqinisekisa ukuba umhlaza u-HER2-positive.
Ngaphantsi
I-HER2 yomhlaza wesifuba esihle ifunyaniswa yi-IHC okanye i-FISH test. Umphumo we-HER 2 positive kubalulekile, njengoko kubonisa ukuba umdlavuza unokuphathwa ngoHerceptin, kunye nePerjeta neKadcyla. Ukuba umhlaza wakho unokuthi u-HER2 ulungile, unokuba nolaka. Ukuqala unyango ngokukhawuleza kuya kunceda ukuphucula ukuhlala kwakho, kunye nokunceda ukukhusela ukuphinda.