Iimeko Ezimbini ezibangelwa ukuguga ngokukhawuleza
Akuqhelekanga ukuba ukhangele iminyaka embalwa okanye ngaphezulu kunokuba ukhona. Kodwa, cingela ujonge iminyaka emininzi kuneminyaka yakho. Kubantu abanenkqubela phambili, iimeko zokuzalwa ezidala ukuguga ngokukhawuleza, akuqhelekanga ukujonga iminyaka engama-30 okanye ngaphezulu kunokuba ikhona.
Nangona i-progeria ihambelana nokuhamba phambili kweHutchinson-Gilford, eli gama linokuthi libhekise ku-Werner syndrome, eyaziwa ngokuba ngumntu omdala.
Hutchinson-Gilford Progeria
I-Hutchinson-Gilford inkqubela phambili iyanqabile, iyithintela malunga ne-1 kwi-4 ukuya kwi-8 yezigidi zabantwana. Abantwana abanenkqubela phambili banokubonakala ngokuqhelekileyo xa bezalwa. Iimpawu zeemeko ziqala ukubonisa naliphi na ixesha ngaphambi kweminyaka emibini ubudala xa umntwana engaphumeleli ukunyuka kwaye utshintsho lwesikhumba luvela. Ixesha elidlulele. umntwana uqala ukufana nomntu osekhulile. Oku kungaquka:
- Ukulahleka kweenwele kunye nokuguqa
- Iimvumba eziphambili
- Amehlo akhuselayo
- Umhlathi omncinci
- Ukwakhiwa kwezinyo ezinciphisekile
- Iphunga elinezikhwebu
- Izitho ezithobileyo kunye namaqela ahloniphekileyo
- Isiqu esifutshane
- Ukulahlekelwa kwamathambo omzimba
- Ubunzima beethambo (i- osteoporosis )
- Ubunzima obuhlangeneyo
- Ukuchithwa kwe-Hip
- Isifo senhliziyo kunye ne-atherosclerosis
Phantse i-97 ekhulwini yabantwana abanenkqubela phambili yiCaucasia. Nangona kunjalo, abantwana abachaphazelekayo babonakala bafana ngokufanayo nangona beentlanga ezahlukeneyo. Uninzi lwabantwana abanenkqubela phambili bahlala malunga no-14 ubudala kwaye bafa ngesifo senhliziyo.
Werner Syndrome
I-Werner syndrome ivela kwi-1 kubantu abayizigidi ezingama-20.
Izimpawu zikaMerner syndrome - njengemigangatho emfutshane okanye iimpawu zesini ezingakhuselwanga - zingabonisa ebuntwaneni okanye ebusheni. Nangona kunjalo, iimpawu zibonakala zibonakala ngakumbi xa umntu ehlasela i-30s. Iimpawu zingabandakanya:
- Ukunciphisa nokwahlula ubuso
- Ukunciphisa ubunzima besisu
- Ikhumba lakho kunye nokulahlekelwa kwamanqatha phantsi kwesikhumba
- Ukunyusa iinwele kunye nokulahleka kweenwele
- Ilizwi eliphakamileyo
- Ukungavamile kwamazinyo
- Iingcamango ezincinci
I-Werner syndrome ivela rhoqo kwiindawo zabantu baseJapan naseSardinia. Abantu abane-Werner syndrome basinda kwinqanaba eliphakathi kweminyaka engama-46 ubudala, baninzi banesifo senhliziyo okanye umhlaza.
Uphando lwexesha elizayo
I-Werner syndrome ibangelwa iinguqu kwi-WRN geni kwi-chromosome 8. Iprojekthi ebangela ukuguquka kwimizimba ye-LMNA kwi-chromosome 1. I-LMNA gene ivelisa i-Lamin A protein, egcina inucleus yeeseli zethu ndawonye. Abaphengululi bakholelwa ukuba ezi iiseli ezingaqinisekanga zixanduva lokuguga ngokukhawuleza okuhambelana nenkqubela phambili. Abaphandi bathemba ngokufunda ezi ntlobo zengqondo ezingabangela unyango kwiimeko zombini kunye nesi sifo esiya kuba sengozi kubantu abaneendlela ezihamba phambili-ezifana ne- atherosclerosis nezinye izifo ezinxulumene nokuguga.
> Imithombo:
Kaiser, HW, (2002). I-Hutchinson-Gilford inkqubela phambili. eMedicine, kufumaneka kwi http://www.emedicine.com/derm/topic731.htm
I-Progeria Research Foundation.
Scientific American.com. (1999). Yintoni esiyayazi malunga nesisifo sikaWerner syndrome kunye nenkqubela phambili, isifo esikhokelela ekugugweni kwangaphambili kubantwana?
Wozniacka, A. (2002). Iprogeria (Werner syndrome). eMedicine