Xa abantu bacinga ngesifo se- Parkinson , iimpawu zokuqala eziza engqondweni ziimpawu zeemoto ezifana nokuthungula, ukunyaniseka, okanye ukunyuka kokunyakaza.
Kodwa iimpawu ezingabonakaliyo , njengengxaki yeemvakalelo kunye neengxaki zokulala, nazo ziqhelekile kwi-Parkinson. Esinye isibonakaliso esingenakuvakala ukuba iingcali zijolise ngokukodwa kukulahlekelwa ngephunga, okwenzeka malunga nama-90 ekhulwini labantu abanesifo sokuqala se-Parkinson.
Ukulahleka kwesiphene (okubizwa ngokuba yi-hyposmia okanye i-dysfunction non-functional) akugcini nje ukuphazamisa umgangatho wobomi bomntu, kodwa enye yeempawu zokuqala ze-Parkinson.
Ngoko ngoku thabatha le ngcamango inyathelo elingaphezulu, iingcali zikholelwa ukuba ukuba ukuphazamiseka komntu kubonakala kwangaphambili, kunokunika inkcazelo kwisifo sabo segazi-kwaye kukho ngoku uphando olwenze le ngcamango ibe yinyani.
Uphando oluPhezulu lovavanyo lokuHlonipha ukuChengeza izifo zeParkinson
Kwiphononongo ye-Neurology, ukuvakala kwentsundu yabantu abangaphezu kwama-2500 abaphilileyo bavavanywa ngo-1999-2000. Aba bathathi-nxaxheba babeneminyaka yobudala engama-75 kwaye bonke bahlala kwimimandla yamadolophu asePittsburgh, ePennsylvania naseMemphis, eTennessee.
Ingqondo yabo yokuvumba yahlolwa ngokusetyenziswa kweSicatshulwa SokuSichazwa kweNkcenkceshelo yoBuchule (BSIT). Kulo vavanyo, abathathi-nxaxheba baqala ukukratshila kunye neentsimbi ezili-12 ezahlukeneyo. Kwaye kwafuneka ukuba bachaze iintlobo ezahlukeneyo ezifana ne-sinamoni, i-lemon, i-petroli, isepha, kunye no-onion ukusuka kwiimpendulo ezine ezikhethiweyo ezininzi.
Izixhobo ezininzi zeedatha zazisetyenziselwa ukuchonga abantu abaphuhlise isifo sikaParkinson ngo-Agasti 31, 2012.
Iziphumo zityhila ukuba ngexesha elilandelelanayo lokulandelelana lwe-9.8 iminyaka, iziganeko ezingama-42 zeziganeko zesifo se- Parkinson zifunyenwe, kwaye ngoko, unxibelelwano lufunyenwe phakathi kwengqondo ephosakeleyo yokunuka kunye nomngcipheko ophezulu we-Parkinson.
Oku kuthetha ukuba abantu ababenomdla ogqithiseleyo (ukuthetha ukuba bafumene kwi-tertile ephantsi kunazo zonke zeBIST amanqaku) babenomngcipheko ophezulu wokuphuhlisa isifo sika-Parkinson.
Okuthakazelisayo, xa isifundo sasiqhekekile ukuya kubuhlanga kunye nesini, ikhonkco yayinamandla kunxaxheba kwiCaucasian, xa kuthelekiswa nabathathi-nxaxheba base-Afrika nabamanye amazwe, kunye namadoda, xa kuthelekiswa nabasetyhini.
Zithini Iingxelo?
Umyalezo osuka ekhaya uthi "ukuphonsa iimvavanyo" kunokukwazi ukuchaza ingozi yomntu wokuphuhlisa isifo sikaParkinson. Oko kwathiwa, kukho imibala embalwa yokugcina engqondweni.
Enye kukuba ukulahlekelwa ngephunga kungenziwa ngenxa yezinye iingxaki zempilo ngaphandle kwe-Parkinson. Ezinye izifo ze-neurological ezifana ne- Alzheimers zingabangela ukuphazamiseka kwemiba, njengokuba kungenakunzima kweemeko ezifana ne- rhinosinusitis engapheliyo. Yingakho ukuqikelela uvavanyo lwevumba oluthe ngqo kwi-PD lubalulekile, kwaye abaphandi abazange balungise konke oku.
Okwesibini, "ukuvumba iimvavanyo" kufuneka uvavanyelwe ukuphazamiseka kokunuka kokunuka. Ukuthi nje umntu ulahlekelwe yiphunga kunokuba aqondakali. Mhlawumbi omnye umntu unzima ukukhetha phakathi kwevumba xa omnye engakwazi ukuchaza izivumba. Okanye umntu unokuba nomda ophezulu ukufumana izivumba.
Ngaloo nto, uphando lubonisa ukuba kwi-Parkinson, kukho ukuhla kwezinto ezichanekileyo ekuqaliseni iphunga, kunokuba kufumaneke ukuvumba kwamanzi, oku kuthetha ukuba "unokuyivumba," kodwa ungatsho ukuba yintoni.
Ekugqibeleni, kubalulekile ukuba ukhumbule ukuba unxibelelwano okanye umbutho nje ukuxhamla okanye ukufumana ngokusekelwe kwiinkcukacha-asikho ipesenti ezi-100 zokuqikelela kwanoma yimuphi umntu. Ngamanye amazwi, umntu unokulahlekelwa ngumqondo wokuvumba kwaye angaze ahlakulele isifo sikaParkinson. Ngokufanayo, kukho abantu abanesifo sika-Parkinson abagcina ingqondo yabo.
Isizathu sokulahlekelwa kwesifo kwiSifo seParkinson
Akucaci ukuba kutheni ukungasebenzi kakubi kwenzeka kwisifo sikaParkinson.
Iingcali ziye zafumanisa ukuba ukuphosa ukulahlekelwa kwee-correlates kunye nenani elingaphantsi le-neurons ye-cholinergic (iiseliti zamagulane ezikhupha iikhemikhali zengqondo, i-acetylcholine) kwi-nucleus basalis ye-Meynart-indawo yesifo esicwangcisa kwi-cortex eyimpumelelo apho uvakalelwa khona livumba.
Ngolu lwazi, uphefumle iimvavanyo ezijolise ekuboneni ukungasebenzi kwe-cholinergic kulungile. Kusasa kakhulu ukuthetha, nangona kunjalo, uphando oluninzi lufanele lwenziwa.
Ukongeza, abanye abaphandi bacetyiswa ukuba isifo se-Parkinson sinokuqala ngokuqala kwinkqubo yokutya kunye ne-bulb yealbactory (ummandla wengqondo elawula umqondo wokunuka), kwaye ingekho i-substantia nigra (apho ekugqibeleni ikhokelela kwi-cell nerve cell protein ukufa). Oku kungenokuba kutheni iimpawu zokuqala, ezifana nokuzibamba kunye nokulahleka kwephunga, qalisa iminyaka phambi kweempawu zemoto ezifana nokuphumla nokuqina komzimba.
ILizwi
Ingaba izazinzulu zithe zavelisa ukuhlolwa kovumba ukuba zihlole ingozi (okanye okanye ixilonge ) isifo sikaParkinson asicacanga. Kodwa, ubuncinane, lo mdla ekulahlekelweni kwesiphene kungabangela ukuba oogqirha baqwalasele i-Parkinson xa izigulane zabo zikhupha. Beka ngokuhlukileyo, kunokuthintela ukuba lo mqondiso ungakunakunyuswa, oko kuqhelekileyo.
Mhlawumbi ngeendlela ezizayo, izazinzulu ziyakwazi ukuyeka isifo sikaParkinson kwiimpawu zayo, xa zihlala kwi-bulb ye-olfactory ngaphambi kokuba ifinyelele kwi-substantia nigra.
> Imithombo:
> Bohnen NI, Albin RL. Inkqubo ye-cholinergic kunye nesifo se-parkinson. Behav Brain Res. 2011 uAgasti 10; 221 (2): 564-73.
> Bowman GL. Ama-Biomarkers ukufumanisa okokuqala isifo se-Parkinson: Isivumba sokungahambelani nokusebenza kakubi. Neurology . 2017 Oktobha 3; 89 (14): 1432-34. I-doi: 10.1212 / WNL.0000000000004383.
> Chen H et al. Ukutshatyalaliswa kunye nesiganeko sePasinson isifo kubantu abadala base-US abamhlophe nabamnyama. Neurology. 2017 Oktobha 3; 89 (14): 1441-47. I-doi: 10.1212 / WNL.0000000000004382.
> IDoty RL. Ukungasebenzi kakubi kwi-Parkinson. Nat Rev Neurol . 2012 Meyi 15; 8 (6): 329-39.
> UMichael J. Fox Foundation. Uphando lwe-Parkinson. Ukulahlekelwa kweeNtsholongwane kunye nezifo zikaPasinson.