Ngo-Matshi 2013, i-US Food and Drug Administration yanikezela isilumkiso malunga neengxaki ezinentliziyo kunye ne-antibiotic azithromycin. Isilumkiso sibonise ukuba abanye abantu banokubeka ingozi yokufa ngokukhawuleza xa bethabatha le nkunkuma, ngakumbi abantu abaneentlobo ezithile zesifo senhliziyo.
Isilumkiso se-FDA senze ukuba kubekho ukusabalaliswa kweendaba eziphathekayo, kwaye kunikwe ukuthandwa kwe-Z-Pack (enqunywe ukuqikelelwa ngamawaka angama-60 ngonyaka), kwaye kwakhokelela ekubeni ukwesaba nokuxhaphaza kwabaninzi kwizigulane kunye noogqirha.
Ingozi Njani IAzithromycin?
I-Azithromycin ilungu leentsapho ze-antibiotic macrolide, kunye ne-erythromycin kunye ne-clarithromycin. Kuye kwaziwa ixesha elide ukuba yonke i-antibiotics yama-macrolide ibangela ukunyuka kwexesha le- QT , umlinganiselo owenziwe kwi- electrocardiogram . Kwaye kwabanye abantu-abo bazalwa benokuhluka kwexesha elide le-QT , oluyimfuza yokuvelisa i- cardiac arrhythmias - nantoni na eyenzela ukuba ixesha le-QT lenze umngcipheko we-arrhythmia eyingozi ekuthiwa yi-tachycardia ye-ventricular .
Ixesha elide le-QT lingaba yingozi kubantu abaneentlobo ezithile zezifo zengqondo, ngokukhethekileyo izifo ze-coronary disease kunye nokuhluleka kwentliziyo .
Ngethamsanqa, ingozi enkulu yokuphuhlisa i-arrhythmia eyingozi kunye ne-azithromycin incinci kakhulu - into enjengamawaka amabini.
I-Azithromycin idibanisa uluhlu olude lwezilwanyana ezinokunyusa ixesha le-QT, kwaye ngoko ke, lunokwandisa umngcipheko wokufa ngokukhawuleza kubantu abanokukhubazeka abanesifo esiphathelene ne-QT syndrome okanye isifo senhliziyo.
Ezi zi yobisi, ngaphezu kwee-antibiotics, zibandakanya imithi emininzi yamarrhythm (izidakamizwa, ezinqabileyo, ziyakuthintela i-arrhythmias), izidakamizwa ezininzi ezixhatshazelisayo kunye nezinye iziyobisi ezisetyenziselwa iimpawu zesisu.
Nolu uluhlu lwamachiza anokwandisa ixesha le-QT, elondolozwe yi-CredibleMeds, i-University based and financeally Centre Centre for Education and Research on therapeutics.
Akukho sizathu sokucinga ukuba i-azithromycin iyingozi nakakhulu kunamanye amachiza kuloluhlu olude: oko kukuthi, kubantu abaneentsholongwane ze-QT syndrome okanye iintlobo ezahlukeneyo zesifo senhliziyo, naziphi na ezi ziyeza yingozi. Kwabanye abantu, ezi ziyobisi ziyakuthathwa ngaphandle kokukhathazeka malunga nama-arrhythmias anxulumene nexesha elide le-QT.
Indlela abantu abasengozini abanokuthi bachongwe ngayo
Amanqaku amaninzi eemfuyo aqatshelwa ukuba achaza abaninzi bala bantu abakhubazekile, kwaye amanqaku amaninzi afunyanwa ngawo onke amaxesha. Nabani na onomnye wamagqabha ezemvelo kufuneka agweme i-azithromycin kunye naliphi na izilwanyana kuloluhlu. Ngelishwa, ukuhlolwa kofuzo akusekho inkqubo eqhelekileyo, kwaye abaninzi abantu abanokutshintsha kwexesha elide abanalwazi lokuba basengozini.
Uninzi lwamagqirha namhlanje lugweme ukusebenzisa naluphi na olu lwamayeza okuphucula ii-QT kubantu abaye bazi i-long-QT syndrome, kwintsapho yabantu abane-long-QT syndrome, okanye kubantu abaye bafumana iziganeko ezingabonakali zokubanjwa kwenyama okanye i- synncope . Ukuba kukho ukukrokra kwendawo ehamba phambili ye-QT, ukuvavanywa koxinzelelo lomzimba kunokusetyenziswa njengolu vavanyo lokuhlola. (Isikhathi se-QT sinokunyusa ngexesha lokuzivocavoca kubantu abathintekayo.)
Kodwa kunikwe imeko yangoku yobugcisa, ubuninzi becandelo loogqirha baya kunika izidakamizwa ezifana ne-azithromycin, xa kudingeke, nakubani na ongenaso isifo senhliziyo esingenayo imbali yomntu okanye yentsapho ehambelana ne-long-QT syndrome, kwaye i-electrocardiogram yeyona ndlela isisiseko - ngokukodwa ukuba (njengokuba kunjalo) le nkunkuma sele isetyenzisiwe ngezihlandlo eziliqela kungabikho uphawu lweengxaki.
Kuyacaca ke, nangona kunjalo, into enokuyenza kukuba uxoxe nodokotela wakho malunga nokuba unokuqhubeka nokusebenzisa i-azithromycin ngokukhawuleza.
> Imithombo:
> Ray WA, Murray KT, Hall K, et al. I-Azithromycin kunye neengozi yokufa kwe-Cardiovascular Death. N Engl J Med 2012; 366: 1881.
> Ulawulo lweZiko lokuTya kunye neDrug. I-Azithromycin (i-Zithromax okanye i-Zmax): UNxibelelwano loKhuseleko lweMithi-mngcipheko weeNkcazo zeNtliziyo eziFa. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm343350.htm?source=govdelivery