Uninzi lwabasetyhini luya kuba neempawu ezingathandekiyo kwiintsuku ngaphambi kokuba zifike ixesha. Ezi zimpawu zinokuquka ukuguquka kwemizwelo okanye ukuva nje.
Kodwa, ukuba unobungqina obunzulu beenguqu eziqhubekayo kwiintsuku ezi-7 ukuya kwezi-14 ngaphambi kokuba ixesha lakho lize liphele ngokupheleleyo kwiintsuku zokuqala zokuphuma kwegazi, unesixazululo sokugula esisemgangathweni (PMDD) .
I-PMDD Ingxaki yoMoya
Ingxaki yesimo sengqondo icinga ukuba yimbangela yokuphazamiseka okutshintsha i-brain neurochemistry kunye neesekethe zokuxhumana. Asinakuqonda ngokupheleleyo indlela ulawulo lwakho olulawulwa ngayo, kodwa siyazi ukuba ukulawula isimo sakho sengqondo kusebuntsheni bakho. Uphando luye lwabonisa ukuba uvakalelo lwenu luyimiphumo yokusebenzisana okunzima phakathi kwezakhiwo zeengqondo, iisitifiketi zengqondo, kunye neekhemikhali zakho zobuchopho okanye i-neurotransmitters.
Yintoni eyenza inguqu yenguqu ekhokelela ekukhathazweni kwemizwelo yindawo yokuphanda. Iziphumo zeengxelo ezikhoyo zibonisa izizathu ezinokubangela izifo zengqondo, eziquka:
- Izizathu ze-Genetic
- Ukuxinezeleka
- Amachiza
- Iimeko zonyango ezingapheliyo
Ukuba unokubandezeleka kwe-PMDD, imbangela yesifo sakho sengqondo sineengcambu ezongezelelekileyo: iihomoni zakho zokuzala.
Oko Siyamazi Ngesisombululo se-PMDD
Amahomoni akho okuzala, okuyi-estrogen, kunye neprogesterone, usebenzisana neekhemikhali zakho zeengqondo kwaye unokuchaphazela imisebenzi ethile kwingqondo yakho, kubandakanywa nomoya wakho.
I-Estrogen kunye neprogesterone ziveliswa ngamaqanda akho kwaye amanqanaba ala ma hormone ayashintsha ngexesha lomjikelezo wokuya esikhathini.
Ezi ziinguqu eziqhelekileyo ze-hormonal ezenziwa ngabasetyhini bonke, kodwa akubona bonke abafazi abahluphekayo kwi-PMDD. Ngoko, into eyahlukileyo iyaqhubeka kwi-3 ukuya kuma-8 ekhulwini kwabasetyhini abane-PMDD.
Ukuba unayo i-PMDD awunawo ukungalingani kwe-hormonal okanye ukusilela. Kunoko, kucatshangelwa ukuba unokuba uvalelekile utshintsho oluqhelekileyo lwe-hormone yomjikelezo wakho wokuya esikhathini.
Into esingayiqondi ngokugcwele yintoni ebangela ukuba uvelwano.
Progesterone / Allopregnanolone
Inkqubo ephezulu yokuxilongwa kwe-PMDD kukuba iimpawu zakho zikhawulelwe kwisigaba esilandelayo somjikelezo wakho wokuya esikhathini. Isigaba esilungileyo sihlandlo phakathi kwe-ovulation kunye nosuku lokuqala lwenyanga yakho. Kwimizuzu engama-28 yokuhamba kwimihla yokuya esikhathini, uhambelana nomjikelezo weentsuku eziyi-14 ukuya ku-28.
Kwi-ovulation, i-ovaries yakho iqala ukwandisa umveliso weprogesterone. Iprogesterone iguqulelwa ibe enye ihomoni ebizwa ngokuthi i-allopregnanolone (ALLO). Iipresterone kunye nee-ALLO ziqhubeka ziphakama de kube uqala ixesha lakho, apho zikhawuleza khona. Enye ingcinga kukuba ukuba unayo i-PMDD uyayikhathalela ngakumbi ukukhutshwa kweprogesterone.
Enye ingcinga kukuba i-ALLO inoxanduva lweempawu zakho kuba idibanisa ne-GABA receptors kwingqondo yakho. I-GABA yinto eqhelekileyo yengqondo okanye i-neurotransmitter leyo, xa ibophelelwe kwiimvume zayo, ilawula ukuphazamiseka nokuxhalabisa. Enyanisweni, isizathu sokuba utywala kunye ne-benzodiazepines zixhalabele kwaye zihlala zithi zibophe kwi-GABA receptors kwingqondo yakho kwaye zenze njenge-GABA yengqondo yakho.
Ngokuqhelekileyo, i-ALLO isebenza kwingqondo yakho njengotywala kunye ne-benzodiazepines.
Kodwa kubasetyhini abane-PMDD kucatshangelwa ukuba into eyahlukileyo nomsebenzi oqhelekileyo we-ALLO. Enye inokwenzeka kukuba kukho utshintsho kwi-GABA ye-receptor senitivity ku-ALLO kwisigaba esilandelayo. Okanye, mhlawumbi kukho isiphako kwimveliso yesigaba se-ALLO. Le ntsebenzo ye-ALLO inokubangela ukuxhalaba, ukunyanzeliswa kunye nokuphazamiseka kwe-PMDD.
Estrogen
Kwakhona, xa uzama ukufumanisa iimeko ezibangelwa i-PMDD, kubalulekile ukukhumbula ukuba i-PMDD iphela kuphela ngexesha lesigxina somjikelezo wakho wokuya esikhathini.
Emva kwe-ovulation, xa amazinga e-progesterone ephakama, amanqanaba akho e-estrogen awela. Ukunciphisa ngokukhawuleza kwinqanaba le-estrogen yakho yinye isizathu esenzayo se-PMDD.
Siyazi ukuba i-estrogen idibanisa kunye neekhemikhali ezininzi zeengqondo ezilawula imizwa yakho. Enye yale michempi yengqondo ibizwa ngokuthi i-serotonin. I-Serotonin inendima enamandla emzimbeni wakho ngokugcina ingqondo yakho yokuphila. I-Serotonin ibandakanyeka ekulawuleni imisebenzi emininzi, kubandakanywa indlela ovakalelwa ngayo, ukulala, kunye nesondlo. I-Serotonin iphinde ichaphazele ukuqonda kwakho, okanye indlela oyifumana ngayo, inkqubo kunye nokuqonda ulwazi oluvela kwindawo yakho.
I-Estrogen ikhuthaza imiphumo emihle ye-serotonin. Kucatshangelwa ukuba ukuba unayo i-PMDD, inkqubo yakho ye-serotonin inokuba yintsholongwane yesiqhelo ngokuqhelekileyo kwi-estrogen ngexesha lesigxina somjikelezo wakho. Ngamanye amazwi, ukuba unayo i-PMDD ukuhla kwesigqirha kwi-estrogen ngexesha lesigxina sokujikeleza kwimizuzu yakho kunokubangela ukulahla okunyanisekileyo kumanqanaba e-serotonin ebuchosheni bakho. Amanqanaba e-serotonin aphantsi anxulumene nomoya ogxininisekile, izifiso zokutya kunye nokungasebenzi kakuhle kwengqondo ye-PMDD. Oku kufunyanwe kukuxhasa ukusetyenziswa kwe-serotonin receptor inhibitors (i-SSRIs) ukuphatha i-PMDD.
Ukuxinezeleka
Ukuba unayo i-PMDD kunokwenzeka ukuba unembali yakho yobuntwaneni, ukukhathazeka ngokomzimba okanye ngokwesondo. Abanye, kodwa akusiyo yonke into, abafazi abane-PMDD banomlando wokungabikho kwengcinezelo ebalulekileyo.
Abaphandi bajonga indlela le mbali yokuxinezeleka ingakhokelela kwi-PMDD. Enye indlela ekhangeleleneyo ithembisa ulwalamano phakathi kokuphendula kwengcinezelo kunye ne-ALLO. Ngokuqhelekileyo, i-ALLO ikhula ngamaxesha obandezelo obunzima, isebenza ngokuqhekeza ngokuqhelekileyo nokunyusa. Uphando lwezovavanyo luye lwabonisa ukuba impendulo ye-ALLO kwixinzelelo olunzulu iyancipha xa ibonakala ingcinezelo engapheliyo.
Ukuqonda indlela uxinzelelo olunokubangela ngayo okanye ukugqithisa ngakumbi iimpawu ze-PMDD okwangoku yiphando lokuphanda. Ngokuqinisekileyo, ukuba unxibelelwano phakathi kwempendulo yakho yokunyamezela kunye ne-PMDD isekela ingqiqo yokuqala ngoncedo lwe-PMDD, kuquka ukuguqulwa kokuphila kunye nokunciphisa uxinzelelo.
Ukusetyenziswa kwe-Immune Activation / Inflammation
Kukho ubudlelwane obusondeleyo phakathi kokudakumba kunye nokusebenza kwenkqubo yakho yokuzivikela. Nangona i-PMDD ixilongwa ngokuhlukileyo kunengxaki enkulu yokudakumba (MDD), kunokubakho inxaxheba ekufuneka impendulo yakho yomzimba ifuthe kwi-PMDD.
Ngenxa yeenguqu eziqhelekileyo kwimpendulo yokuzivikela emzimbeni kunye nokuvuvukala ngexesha lomjikelezo oqhelekileyo wokuya esikhathini, abafazi abaneemeko ezithile ezivuthayo ezifana ne-gingivitis kunye nesifo sesibindi sokubandezela bangabona ukugqithisa kweempawu zabo kwisigaba esilandelayo.
Uphando lwangaphambili kule ndawo lubonisa ukuba abasetyhini abaneempawu ezibalulekileyo zokuqala ziba neempendulo zokuvuvukala kwisigaba esilandelayo xa kuthelekiswa nabasetyhini abaneempawu ezincinci.
Genetics
Izifo zengqondo ziyaziwa ziqhutywa kwiintsapho. Ukukwazi kwakho ukuhlakulela ingxaki yemoya ngexesha lakho lobomi lizuze ilifa kubazali bakho ngokusebenzisa izifo zakho. Njengoko iimpawu ezibonakalayo ezifana nokuphakama kunye nombala wamehlo zizuzwe njengefa, ngoko ke ezinye izifo zengxaki, kuquka umhlaza kunye nokudandatheka. Kuze kube kutshanje, ayikho isiseko sohlobo lwe-PMDD esasungulwe.
Abasetyhini abane-PMDD banomdla ngakumbi kwiinguqu ze-hormone eziqhelekileyo kwisigaba sokuqala sonyaka. Abaphandi be-NIH bafuna isizathu sokuba. Oko bakufumanisa kukuba abafazi abane-PMDD batshintshe kwisinye sezixhobo zengcambu ezilawula indlela abasabela ngayo kwi-estrogen kunye neprogesterone. Ngamanye amazwi, kukho imvelaphi yezofuzo ze-hormonal sensitivity ezibonwa kwabasetyhini abane-PMDD.
Oku kufumaneka ngokugqithiseleyo ukuba unayo i-PMDD. Inika ubungqina obunobunzululwazi bokuthi into ethile yezinto eziphilayo kunye nokugqithiseleyo kwakho kubangela ukuba isimo sakho sitshintshe. Iqinisekisa ukuba i-PMDD ayiyona nje indlela yokuziphatha.
Kodwa ezi ziphumo akuzona ibali elipheleleyo. Impumelelo yolu cwaningo, ke ke, ikhuthaze ezinye izifundo kwaye ivula umnyango wokufumana iindlela ezintsha zonyango lwe-PMDD.
ILizwi
Mhlawumbi, kukho izinto ezininzi ezichaphazela ukuphuhliswa kwe-PMDD, kodwa enye into eqinisekile kukuba i-PMDD imeko yinyani kwaye kungekhona nje into enokwenzayo okanye ongayifisa. Mhlawumbi ngaphezu kweyodwa indlela ikhoyo phakathi kweenguqu zakho ze-hormone utshintsho kunye ne-PMDD.
Ubungqina bokuba kukho iziphumo ezichaphazelekayo ze-PMDD kunokukunceda ukuba uchaze ukuba kutheni ezinye iindlela zonyango zisebenza kakuhle kuwe kodwa kungabanye, kwaye ngokufanayo. Kubalulekile ukugcina engqondweni yakho njengoko wena kunye nodokotela wakho uhlola iindlela ezahlukeneyo zokonyango ukukunceda uphile kakuhle nge-PMDD.
> Imithombo:
> Hantsoo L. & Epperson CN (2015) Ingxaki ye-Premenstrual Dysphoric Disorder: Epidemiology and Treatment. I-Curr Psychiatry Rep., 17 (11) 87. I-doi: 10.1007 / s1920-015-0628-3
> Dubey N, Hoffman JF, Schuebel K, Yuan Q, uMartinez PE, Nieman LK, uRubinow DR, Schmidt PJ, Goldman D. I-ESC / E (Z), i-ESC / E (Z) yinkimbinkimbi, i-molecular cell pathway eyahlukileyo kwi-ovarian steroids kwi-Premenstrual Dysphoric I-Disorder, i-Molecular Psychiatry, ngoJanuwari 3, 2016, itha: 10.1038 / mp.2016.229.