Enye yeempawu ezikhethiweyo zomhlaza wesifo somhlaza ngumsebenzi wayo wokususa i- testosterone . Le "I-Achilles Heel" yomhlaza wesifo seprotate yafunyanwa ngowe-1940 xa ukukhishwa kwamagqabi okugqithwa kwaboniswa ukuba kuphulukiswe umhlaza. Ngowe-1985, i-Lupron, iyeza elinojoza eliye lafeza into efanayo yavunywa yi-FDA.
I-Lupron isebenza ngokukhohlisa amacwecwe ukuvala umveliso wabo we testosterone.
Impumelelo
I-Lupron ilawula umhlaza wesifo somhlaza ngokwesilinganiso seminyaka emibili ukuya kweyesithandathu kwimadoda eneesifo se-metastatic, kunye neminyaka engaphezu kweyishumi xa unyango luqaliswa unyango ngaphambi kokuba i-diagnosis isifo. Xa i-Lupron iyeka ukusebenza, ezinye i-hormonal agents ezifana neCasodex okanye iNilandron inokubonelela ngokulawula kwexeshana, kodwa ixesha lokusebenza (ukugcina i-PSA phantsi) ngokuqhelekileyo lihlala lingaphantsi konyaka.
Ukuphikisana kuye kwahlaselwa kwiziko lemfundo malunga nokuba ukuhla kwelula kumazinga e- PSA kubonisa ngokuchanekileyo ukuba ukusinda kwesigulane kuya kwandiswa. Ngaloo mihla, i-FDA iya kuvuma kuphela isilwanyana esitsha ukuba amaxwebhu omenzi weyeza amayeza aphucule ukusinda kwilingo elilawulwa yi-placebo. Ukubonakaliswa kokuphila okuphuculweyo ngumngeni onzima kunokuba kubonise nje ukuba unyango lubangela ukuhla kwexeshana kumazinga e-PSA.
I-Zytiga (i-abiraterone) eyayifundwa kumadoda anesifo se-metastatic esasichasene neLupron yabonisa la mavolontiya aneemetastatic, i-Lupron-resistant-resistant cancer prostate eyayifumene ne-abiraterone iboniswe ukuba iphile kuma-33% ngaphezulu kunamadoda athola indawo ye-placebo.
I-Zytiga yilezi zixhobo zonyango ezisebenza ngokuxhaphaza ukufumanisa ukutshatyalaliswa kwe-Lupron (echazwa njengomlinganiselo wesifo somhlaza nangona i-testosterone ye-zero egazini) ayikho imbangela yomhlaza wesifo oye wafunda ukukhula ngaphandle kwe-testosterone.
Kunoko, ukuxhathisa kwe-Lupron kubangelwa yintsholongwane yomhlaza wesifo seprotate esefundile indlela yokuvelisa i-testosterone yabo ngaphakathi.
Isiphumo saso sokusebenza sisebenzela ngokuthintela i-enzyme ebalulekileyo ephakathi kweseli yomhlaza, i-enzyme eyingxenye ebalulekileyo kwinkqubo yokwenziwa kwe testosterone. Umphumo womnatha wukuthi iseli lomhlaza livaliwe ekuveliseni i-testosterone yayo.
Imiphumela
Imiphumo emibi yeZytiga inokuquka ukuguquka kwamanqanaba e-potassium egazini, kwaye kwiimeko ezinqabileyo, ukungasebenzi kwesibindi. I-Zytiga iphinda ikwandise isenzo seepilisi ze-cholesterol ezifana ne-Lipitor kunye neCrestor ukuze i-dosage yabo idinga ukuncitshiswa.
Ukugcina amanqanaba e-potassium kwinqanaba eliqhelekileyo iZytiga lilawulwa ngokubambisana ne- prednisone , uhlobo lwe-cortisone. I-Cortisone ingaba nemiphumo emibi nayo. Ngamanye amaxesha kunxulumene neentlungu zesisu kunye nezilonda zesisu. Amanqanaba eshukela ephezulu aphezulu anokufumaneka nakubantu abanesifo sikashukela.