Iziyobisi ezenzelwe ukuphula kunye nokukhulula i-mucus kwiCOPD
Enye yezinto eziphambili zesifo esingapheliyo sesifo se-pulmonary disease (COPD) kukuveliswa ngokugqithisileyo kwe-mucus emiphakeni. Oku kukhulula, ngamanye amaxesha okubhekiswa njengengxube engapheliyo yokukhupha i-hypersecretion, kubangelwa ukuvuvukala kwexesha elide okwandisa zombini inani kunye nobukhulu bezinto ezibizwa ngokuthi "iiseli ze-goblet" ezihamba ngeendinyana zomoya.
Ngelixa iiseli zebhendi zifakela i-mucus njengendlela yokukhusela, kunye neCOPD umveliso ogqithiseleyo unokuvala iindinyana, okwenza kube nzima ukuphefumula.
Enye indlela yokucima lesi sihloko sinomuthi owenziwe ngomlomo okanye ongathandabuzekiyo obizwa ngokuba yi-mucolytic. I-Mucolytics isebenza ngokuqhawula izibophelelo zeekhemikhali ngaphakathi kweemfihlo, ziphule ukuze zenzeke ngokukhawuleza.
Nangona i-mucolytics ingabonwa njengenxalenye yenkqubo ekhoyo yangoku yokunyangwa kwonyango lwe-COPD , izikhokelo ze-2017 ezikhutshwe yiNkqubo yokuLungiswa kweMihlaba yokuLungisa izifo (GOLD) zibonisa ukuba zinokubaluleka kubantu abangafumani i-corticosteroids .
Ukuqwalaselwa kweMucolytic Drugs ekuphatheni iCOPD
I-Mucolytics inokuthi ithathwe ngomlomo kwipilisi okanye isiraphu okanye ifakwe kwi- nebulazer . Ezinye zeendlela eziqhelekileyo ezisetyenziswa kwiCOPD ziquka:
- ICarbocysteine
- N-acetylcysteine
- Erdosteine
- IMecysteine
- Guaifenesin
- Bromhexine
Inkqubo yesenzo ingahluka ngeziyobisi. Ngokomzekelo, iCarbocysteine, isebenza nge-metabolism yeeseli ezinqabileyo kwaye inika neenzuzo zokulwa ne-antioxidant kunye ne-anti-inflammatory.
I-N-acetylcysteine, ngokuphambene, iphula iibhondi ezibamba ubumbano kunye kunye nokuguqula ukungalingani kwamachiza kunye nama-antioxidants.
Iziphumo zempembelelo ziyakwazi ukutshintsha zombini ngohlobo lweziyobisi kunye nokuqulunqwa. Kuthetha ngokubanzi, isicupunu nesifo sohudo sinomdla ochaphazelekayo ochaphazelekayo ohambelana namacwecwe, ngelixa iimpawu zamanzi zingabangela ukuba i-bronchial spasms and rashes.
Iifom ze-Nebulized ziyakwenza ngokufanayo imbopha ebuhlungu, impumlo yempumlo, kunye nokubunjwa kwamakhanda amhlophe emlonyeni nasemlonyeni.
Ngokubanzi, i-mucolytics ithathwa njengekhuselekile kwaye ihambelana nomngcipheko omncinci wezehlakalo ezimbi kubantu abaneCOPD. Xa kuthethwa oko, kubalulekile ukuthetha noogqirha wakho malunga nayiphi na imiphumo emibi, ukusebenzisana, okanye ukuchasene okuhambelana nomkhiqizo we-mucolytic, ingaba umiselwe okanye uthengiwe kwi-counter.
Ukusebenza kweMucolytics kwiCOPD
Nangona kusetyenziswe ukusetyenziswa kwezidakamizwa ze-mucoactive kwi-COPD, ubungqina obunjalo abuxhasayo ngokusebenza kwabo.
Uhlolo lwe-2015 lwezilingo ezingama-34 lugqiba ekubeni abo bathatha i-mucolytics babengenakuncipha ukuba bafumane ama- COPD . Xa kuhlaziywa iziphumo, kunjalo, oku kuguqulelwe ekunciphiseni okunciphisa ukunyuka komnye kwiminyaka emithathu. Olunye uphando luye lwafumana ezinye izigqibo ezifanayo.
Nangona kunjalo, naphezu kwezi mphoso, abanye baye baxela ukuba i-mucolytics inendawo kwindawo yokwelashwa kweCOPD. Ngenxa yokukhathazeka ngokukhuseleko kwexesha elide lokusebenzisa i-corticosteroid , kuye kwaba neengcebiso zokuba zifanelekile kwiCOPD ephezulu apho umngcipheko wokukhubazeka uphezulu ngaphandle kokusetyenziswa kwe-steroid.
I-Mucolytics inokunceda ekunciphiseni inani lezinto ezinzima kunye nokunikezela ukuphucula umgangatho wobomi.
Omnye u-substudy ohambelana ne-Bronchitis Randomized kwi-NAC Cost-Utility Study (i-BRONCUS) iphetha ngokugqithiseleyo ukuba, xa isetyenziswe nge-corticosteroid enganyangekiyo, izidakamizwa ze-mucolytic zinganciphisa ukukhushulwa kwe-COPD ngama-21 ekhulwini.
I-Mucolytics ingaba luncedo kubantu abangenakuxhomekeka kwi-corticosteroids okanye bakunzima nge-inhalers eziphathekayo.
Imithombo:
> I-Global Initiative ye-Lung Disease. (2017) Isikhokelo sePocket kwi-COPD Ukuxilongwa, ukuPhathwa, nokuPhepha: IsiKhokelo seNgcali zoLondolozo lwezeMpilo (iNgxelo ye-2017) .
> Loukides, S .; Bakakos, P .; kunye neKostikas, K. "I-Mucolytics ku-COPD: Njengewayini elibomvu?" IPNEUMON. 2013; 4 (26): 1-4.
> Poole, P .; Chong, J .; kunye neeCates, J. "Ama-Mucolytic agents kunye ne-placebo ye-bronchitis engapheliyo okanye isifo esingapheliyo se-pulmonary disease." Cochrane Database Syst Rev. 2015; 29: 7: CD001287.