Ufumanise ukuba unesitoreji esinyithi (esabizwa ngokuba yi-hemosiderosis) esecaleni kwiimfomfele ezibomvu zegazi ezifunekayo. Usenokuba wazi malunga nale mngcipheko ekuqaleni kwiplani yonyango kodwa mhlawumbi awuzange. I-Iron overload ingabangela iingxaki ezininzi ngoko kubalulekile ukuba kube necwangciso lophuhliso olungcono.
I-iron chelators (imithi esusa isinyithi emzimbeni) isetyenziswa ngabantu abano-thalassemia okanye ezinye iindidi ze-anemia ezifuna igazi elibomvu kwi-cell cell.
Abantu abane- inherited hemochromatosis baphathwa nge-serial phlebotomy (ukususwa ngokomzimba kwegazi).
Izinketho zeArhente
Njengamanje, eUnited States, kukho iintlobo ezahlukeneyo zentsimbi ye-iron. Ngamnye unayo ipropy and pro. Izinto ezininzi zilinganiswa xa zigqiba ukuba yiyiphi imithi esetyenziswayo.
Deferoxamine
I-Deferoxamine (igama lokutshintshwa kwegama lomtsalane) lisetyenziswe iminyaka engaphezu kwamashumi amane eUnited States. I-Deferoxamine inokunikwa njenge-intravenous (IV) e-infusion esibhedlele kodwa ngokuqhelekileyo abantu abane-ironload overload banikela i-deferoxamine ngaphantsi (phantsi kwesikhumba) ekhaya. Ukunyuswa kwegazi kuhanjiswa ngaphezu kweeyure eziyi-8 ukuya kwi-12 ngobusuku usebenzisa ipompo encinci yamandla ebhetri. Ingxelo yesikhumba yengingqi iyakwenzeka kodwa ingaphathwa ngokunciphisa umthamo / izinga lokunyuswa kwamanzi okanye i-krikcortisone ukhilimu.
Uninzi lwabantu lunyamezela i-deferoxamine kakuhle kodwa kuba ukunyanzelwa kwegazi kufuneka kunikwe ixesha elide, abantu abaninzi banxinwa yile nyango.
Ukuphulaphulwa kunye nokulahleka kombono kungenzeka kumazinga aphezulu, ngoko xa unyangwa nge-deferoxamine kufuneka ube nokuvalelwa kwonyaka kunye nokuhlolwa kwembono.
Deferasirox
I-chelator yesinyithi eqhelekileyo esebenzisa e-United States i-deferasirox. Kusebenza ngokususa isinyithi kwisibindi kunye nentliziyo, iinxalenye zombini zininzi zineentsimbi ezingaphezulu.
I-Deferasirox ivela kwiifom e zimbini: i-tablet ephazamisekiyo (echitshiweyo kwi-liquid) ebizwa ngokuba yi-Exjade kunye nebhebhile engatshitswa ngokuthi nguJadenu.
Enye yezona zinzuzo ezinkulu ze-deferasirox kukuba yimiyeza yomlomo ethathwa kanye ngosuku. Ngelishwa, ayikho ifom ye-deferasirox. Nangona uJadenu efika njengokulula ukugwinya ithebhulethi, abaninzi abantwana abane-anemias abaxhomekeke kwi-transfusion baya kuhlakulela i-iron overload ngaphambi kokuba bakwazi ukugwinya iipilisi. Kula bantwana, i-Exjade ingasetyenziswa.
Ingcipheko kulo mgaqo kukuba ithanda icky. Ithebhulethi ichithwa kwinqwelo kodwa kaninzi ayichithanga ngokupheleleyo kwaye i-liquid ithatha ukuthungwa kwe-chalky. Ukunambitha kungancinci ngenye indlela ngokuyifaka kwi-apula okanye kwijusi ye-orange. Kukho uvavanyo lwekliniki oluqhubekayo ukuvavanya ukuphumelela kwe-granules ye-deferasirox engafakelwa ngokutya. I-Deferasirox ingasetyenziselwa kubantu abane-thalassemia abangathembekiyo kwi-thalassemia ngaphezu kweminyaka eyi-10.
Deferiprone
I-Deferiprone (i-Ferriprox) iyona mva ye-iron chelator evunywe e-United States. Nangona i-deferiprone yimiyeza yomlomo, ngoku ithathwe kathathu ngosuku. Iza njengepilisi okanye i-liquid. Kubonakala sengathi i-deferiprone ingaba yimichiza engcono kakhulu yokususa intsimbi entliziyweni.
Nangona uninzi lwabantu lunyamezela i-deferiprone ngaphandle kwemibandela, ininzi malunga nefuthe elichaphazelekayo liyi-agranulocytosis, iibalo ze-neutrophil eziphantsi kakhulu ezingabangela ingozi yokusuleleka. Ngethuba ngeli liyeza, i-neutrophil count kufuneka ilandelwe ngokufutshane kunye neengxelo zegazi ezipheleleyo ngeveki (CBC).
Uluhlu lweNyango
Abanye abantu abanenkunkuma yensimbi bangafuna unyango kunye ne-chelator engaphezulu kweyodwa. Oku kungathatha i-deferasirox okanye i-deferiprone imihla ngemihla nge-deferoxamine infusions 3 ukuya kuma-4 amaxesha ngeveki.
Ukuba unemibuzo malunga nokuba i-iron chelator ethile ilungile yini, xubusha ngayo nomboneleli wakho wezempilo.
Qinisekisa ukuba uthatha iyeza njengoko ulandisiwe kwaye wazise ugqirha wakho kwanaluphi na ukukhathazeka onayo.
> Umthombo:
> Schrier SL kunye neBacon BR. Ulwaphulo lwe-Chelation lwe-thalassemia kunye nezinye i-iron overload state. > Ku: UkuPhakamisa, I-Post TW (Ed), UpToDate, i-Waltham, MA.