I-Well-Tolerated, Treatment Safe ye-Migraine engapheliyo
Ukunyanga kwama-migraines angapheli kugxininise ukudibanisa kokungenelela kokuziphatha, njengokuphepha kokukhusela, kunye nokunyanga kwamayeza. Ngelixa le miqathango isebenza kwabanye abantu, abanye baxhatshazwayo okanye abanakuxhomekeka kwiindlela eziqhelekileyo zokunyamekela. Kulezi zihlandlo, umntu unokuqwalasela ezinye iindlela zokwelapha ezingaqhelekanga, njengeBotox .
Yintoni iBotox?
I-OnabotulinumtoxinA, eyaziwa ngegama loshishino iBotox, i-toxin eyenziwa yi- bteria i-Clostridium botulinum kwaye isebenza ngokuthintela uxhumano lweentsimbi, oluye linciphisa umsebenzi we-muscle. I-Botox yavunywa yi-FDA ngo-2010 ngokuthintela ukuthatha imithi engapheliyo.
I-injection yeBotox ngenxa ye-migraine yakho engunaphakade yindlela yokukhawuleza, ngokuqhelekileyo ihlala imizuzu eyi-10 ukuya kwe-15, eneendawo ezininzi ezijikeleze intloko nentamo. Ngelixa kunokubakho ukuvutha okuncinci okubanjiswa kunye nejoyi ngalinye, ukuphazamiseka kukufutshane, kwaye abaninzi abantu bayayinyamezela.
Ngaba iBotox isebenza?
Inzululwazi emva kweBotox ithemba, nangona kungabikho ukuphonononga kwehlabathi ukubonisa ukuba encinci imodareythi emihle.
Isifundo esinye kwiNtloko sihlalutye malunga nezigulane ezingama-1300 ezine-migraine engapheliyo kwinkqubo ye-PREEMPT. Inkqubo ye-PREEMPT isilingo seekliniki ezingama-56 esiphando ngokusetyenziswa kwe-Onabotulinumtoxin A njengonyango olukhuseleyo lwe-migraine.
Kwisifundo se-PREEMPT, abathathi-nxaxheba babenomsebenzi wokufumana ii-injections kwintloko nentloko yentloko ye-Onabotulinumtoxin A ngokubhekiselele kwisilenze se-placebo nganye iiveki ezili-12 ngeesisigidi (ama-injection engama-31). Kwabathathi-nxaxheba, iipesenti ezingama-35 zahluleka ukukhusela imithi yesithathu yokukhusela, kodwa i-65 ekhulwini yayiphumele enye.
Bonke bafumana ukuxilongwa kwe-migraine engapheliyo. Abathathi-nxaxheba kunye ne-Botox injectors babengaboniyo unyango, oko kuthetha ukuba abazange bazi ukuba yeyiphi iilenki abayifumanayo (iBotox kunye ne-placebo).
Iziphumo zityhila ukuba abo bafumana i-Onabotulinumtoxin A injections banokuthi bancitshiswe kwinani leentloko zabo ekupheleni kwexesha lokufunda (iiveki ezingama-56). Kwakhona banokuthi bangabika ngaphantsi "iiyure zentloko" kwiintsuku zabo.
Kwisifundo esithile kwi -Journal of Headache and Pain , izigulane ezingama-254 ezine- migraine ezingapheli zijojowe nge-Onabotulinumtoxin A kwiKliniki yase-Hill Migraine eNgilani. Amaphesenti angaphezu kwe-90 ala bathathi-nxaxheba aye azame 3 unyango lwe-migraine kwixesha elidlulileyo kwaye akazange aphendule. Bafumana iijoyi zeBotox kwiprotokholi efanayo, njengoko kufezwe kwisifundo se-PREEMPT. Abathathi-nxaxheba bagcinwe idayari ubuncinane iintsuku ezingamashumi amathathu ngaphambi kokuba emva kokufumana ii-injections.
Iziphumo zityhila ukuba i-OnabotulinumtoxinA iintsuku zentsholongwane ezincitshiswayo ezincinci kunye neentsuku ze-migraine ngama-50 ekhulwini, kwaye kwandiswa iintsuku ezingenasisiseko kwiintsuku zokuqala. Ipesenteji yezigulane ezifeze ubuncinane be-75 ekhulwini lokunciphisa iintsuku zentloko kunye neentsuku ze-migraine zaba ngama-14 ekhulwini kunye nama-24 ekhulwini, ngokulandelana.
Ukusetyenziswa kwe-Onabotulinumtoxin Kwakhona kwaphumela ekukhuleni komsebenzi.
Ekugqibeleni, isifundo kwiJAMA , esiluhlalutyo olukhulu kwiimvavanyo ezininzi ezilawulwa ngandlela-thile eziqhathanisa i-toxin A kunye ne-placebo, kwakhona iphakanyiswe inzuzo encinane ye-migraine-Botox. Kulo hlalutyo, abathathi-nxaxheba babebandakanya abo abaneentlobo ezahlukeneyo zeentloko ezifana: i-episodic migraine, i-headache-type headache, kunye nentloko ye-migraine.
Iziphumo zacetyiswa ukuba i-Botox inenzuzo ekukhuseleni imithi engapheliyo, kodwa kungekhona kwi-epradic migraine okanye kwiintsholongwane ezingapheliyo. Kubalulekile ukwazi ukuba ukunciphisa ngokupheleleyo kwinani lentloko nganye ngenyanga kule sifundo kufunyenwe ukuba kubekho iintsuku ezi-2 ukuya kwezi-3-ezincinci, kodwa zibalulekileyo kuninzi.
Kufana nokuba neveki enye ngenyanga ngaphandle kweentloko.
Ziziphi ii-Downsides zeBotox ?:
Kwenye, njengamanye amayeza, kukho iziphumo zecala. Kuhlolisiso lwe- JAMA , le miphumo yabonakele yabonwa kubafundi abathathi baninzi kwi-Botox injections kwiqela le-placebo-ekuthethwa ngalo, basenqabile, kodwa bafanelekile ukuthetha.
- Ubuthakathaka obuthathaka
- Blepharoptosis
- Ukuqina kancinci
- Pherehesia
- Ukhuni lukhuni
- Intlungu yentlungu
Intloko nayo ingakhokelela kwiiyobisi zeBotox-into ephazamisayo-kodwa ungakhathazeki, oku kudla ngokukhawuleza.
Omnye umgca wukuthi iBotox inokubiza kakhulu. Iinkampani ezininzi ze-inshorensi zifuna amaxwebhu amaninzi ukuba awuphumelelanga nezinye izigulane zokukhusela imithi ngaphambi kokumboza i-Botox, kwaye ngamanye amaxesha, nangona oku kungasebenzi.
Ngaphantsi
Uphando olungakumbi lwezesayensi kwiBotox luya kunceda. Oko kuthethwa, iBotox ibonakala inika inzuzo ethile ekukhuseleni i-migraines engapheliyo. Kuhle ukuba uqaphele ukuba unokusebenzisa i-Botox kunye neminye imishanguzo ye-migraine-ngoko kunokukunika ukugqithiswa okongezelelweyo okungazange ufumane kunye neyeza lakho kuphela.
Imithombo:
I-Aurora SK, i-Winner P, i-Freeman MC, i-Spierings EL, i-Heating JO, i-DeGryse RE et al. I-OnabotulinumtoxinA yebhokisi yebhokisi yeeNtloko : I-Botox-A yokuChoxiswa kweMigraine engapheliyo : Imibuzo ebuzwa ngokuqhelekileyo okanye unyango lwe-C i-Migraine engathandekiyo: Uhlalutyo oluxutywe kwi-week-56 I-PREEMPT Programme Clinic. Intloko. 2011 I-Oct; 51 (9): 1358-73.
UJackson JL, Kuriyama A, Hayashino Y. Botulinum I-Toxin A ye-Prophylactic Treatment ye-Migraine kunye neNtsholongwane yeNtloko kuBadalaAUhlalutyo lwe-Meta. JAMA. 2012; 307 (16): 1736-1745.
U-Khalil M, uZafar HW, Quarshie V, Ahmed F. Uhlalutyo olwenziweyo lwe-OnabotulinumtoxinA (BOTOX) kwi-Treatment of Chronic Migraine; I-Real-Life Data kwi-254 Iziguli ezivela eHull, e-UK. J Ubuhlungu bentloko. 2014 Sep 1; 15: 54.
Rothrock, JS (2012). Umama weNtloko weMerika. Ibhokisi yeBhokisi yeNtloko .