I-Stevens-Johnson Syndrome (i-SJS) yinto engabonakaliyo kodwa engasongela ubomi ebusweni besikhumba (i-epidermis) ihlula ukusuka kwinqanaba elingaphantsi ((dermis) le-epidermis, okubangelwa ukufa kwe-tissu ngokukhawuleza.
Ngelixa i-SJS ingabangelwa yintsholongwane yezifo, kuquka i-mumps kunye ne-typhoid, zixhomekeke kakhulu kwi-hypersensitive.
Ukunyuka kwengqondo kwenzeka xa ukutyalwa kwesinye isilwanyana kudala impendulo engafaniyo yomzimba apho umzimba uhlasela iiseli kunye nezicubu.
Izidakamizwa ezithile ze- antiretroviral ezisetyenziselwa ukunyanga i-HIV zidibene nomngcipheko ophezulu we-SJS kuquka i-Viramune (nevirapine), i-Ziagen (abacavir) kunye ne-Isentress (raltegravir).
Amayeza okulwa namayeza, ikakhulukazi amayeza e-sulfa, ahlala echaphazelekayo kwiziganeko ze-SJS. Enyanisweni, ukusetyenziswa kwe-rifampin ye-anti-tuberculosis yezidakamizwa kunokunyusa umngcipheko we-SJS kubantu abane-HIV ngama-400 ekhulwini.
Iimpawu
I-SJS isoloko iqala ngeempawu ezintle ezifana nokukhathala jikelele, umkhuhlane kunye nomqala. Oku kulandelwa ngokuqhelekileyo ngezilonda ezibuhlungu emlonyeni womlomo, imilomo, ulwimi, kunye neelusiki zangaphakathi (kwaye ngezinye izikhathi i-anus kunye nezitho zangasese). Inokubandakanya iindawo ezininzi zobuso, i-trunk, iingqungquthela, kunye neengcambu zeenyawo, kubonakaliswe nge-blisters malunga ne intshi ngobukhulu.
Iimpawu zivame ukuvela kwiiveki zokuqala zokuqala unyango olutsha. Ukuba ishiywe ingaphatyathwa kwaye iziyobisi zingagqitywanga, umonakalo wembutho unokwenzeka kwaye ukhokelela kumonakalo kwamehlo, ukuphunga, okanye ukufa. I-Sepsis , inkqubela phambili ngokukhawuleza, imeko yokusongela ubomi, inokubangela ukuba iibhaktheriya ezivela kwi-SJS isifo singene egazini kwaye zisasazeka kuwo wonke umzimba, kubangela ukutshatyalaliswa kobuhlungu kunye nokungaphumeleli komzimba.
I-SJS ngamanye amaxesha iphosakele nge-erythema multiform, i-hypersensitivity yamachiza ebonakalisa ukuphakanyiswa, okubomvana okanye okubomvu. I-SJS, ngokuphambene nayo, idibaniswa nokuqhuma kwesibhakabhaka esinokudibanisa nokwenza amaphepha amakhulu ekhuni. Nangona kwinqanaba lokuqala lenkcazo, oogqirha abaninzi baya kuchaza i-SJS inqabana "njengomsindo" ngenxa yokubonakala kwabo ebuhlungu.
Unyango
Ukuyeka ukukhutshwa kwesicatshulwa esicatshulwayo kukuqala kuqala ukuba i-SJS ikhunjulwa. Kwiimeko ezinzima, unyango lwe-SJS lufana noko kwiigulane ezinokutshisa okukhulu, kubandakanya ukugcinwa kwamanzi, ukusetyenziswa kokungabambisani, ukulawula ukushisa, kunye nenkxaso yokuncedisa ukulawula intlungu kunye nokutya.
Xa isigxina simisiwe ngenxa ye-SJS, akufanele siqaliswe kwakhona
Mngcipheko
Ngelixa i-SJS inokuchaphazela nabani na, kukho abathile abonakala bebezobomi bezityalo zabo. Uphando lubonisa ukuba abantu abanegalelo le-HLA-B 1502 banamathuba akwazi ukuphuhlisa i-SJS kunye nobungozi obukhulu obonakalayo phakathi kwabantu baseTshayina, amaNdiya kunye ne-East Asia.
Ukongeza kwezidakamizwa ezibhalwe apha ngasentla, inani leemithi eziqhelekileyo zidibaniswe ne-SJS. Ziquka:
- Izidakamizwa ezichasene nezidakamizwa (i-NSAID) ezingezange-nonsteroidal ezifana ne-acetaminophen, ibuprofen kunye ne-naproxen sodium
- Penicillin
- Iyeza-anti-gout ezifana ne-allopurinol
- I-Anticonvulsants esetyenziselwa ukunyanga isisu
- I-Antipsychotics isebenzisa ukuphazamiseka kwengqondo
- Ukunyanga kwamayeza
> Imithombo:
> Knight, L .; Muloiwa, R .; Dlamini, S. et al. "Izinto ezinxulumene nokufa kweNtsholongwane enabantu abanentsholongwane kaGawulayo kunye noStevens-Johnson Syndrome kunye neTyxic Epidermal Necrolysis." PLoS ONE. 2014; 9 (4): e93543. INGXELO: 10.1371 / iphephandaba.pone.0093543.
> Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu (DHHS). "Izikhokelo Zokusetyenziswa Kwee-Antiretroviral Agents kwi-HIV-1-Abadala abakhulelweyo kunye ne-Adolescents: Imida kuMnxeba noKhuselo - Imiphumo emibi yezidakamizwa ze-Antiretroviral." EWashington, DC; fi kelele ngoJuni 7, 2015.