Iingcali zenzululwazi ngoku zifumana izilwanyana zofuzo. Enye imfuza ethile, eyaziwayo njenge- FTO, ibonakaliswe njengobunxulumano oluchanekileyo kunye nokukhuluphala.
Ukunyaniseka kweMatriki
Abaphandi baye bafumanisa ukuba i-FTO ifufayile ingabamba iqhosha ngokubhekiselele kulokuba abantu baxhomekeke ekutyebeni.
Ngokomzekelo, izazinzulu ziye zafumanisa ukuba i-FTO ifufti inokukwenza ukutyekela ukutya kunye nokuphuhliswa kokukhuluphala kwintsholongwane .
Kwaye ekufundeni izigulane ezingaba ngu-1 000 eMzantsi Afrika, izazinzulu zathola amanqaku amane ezakhi zofuzo (enye yazo ibandakanya i-FTO gene) eyayinxulumene ne-BMI ephezulu eneminyaka eyi-13.
Olunye uphando olujonge imiphumo ye-FTO kuma-3 000 abantwana baseTshayina bafumanisa ukuba iziphumo ze-FTO kwi-BMI ephezulu zakhokelela ekungciphekweni komngcipheko wegazi ophezulu (uxinzelelo lwegazi), owaziwa ukuba ubangelwa ukukhuluphala.
Ijethi ye-FTO ibonakala ihambelana nemiphumo yesondlo, ukutya okudliwayo, kunye ne-index mass mass (BMI). Ngokusekelwe kwiziphumo zophando zakutshanje, abaphandi ngoku bakholelwa ukuba kunokubakho ubudlelwane phakathi kwe-FTO, ukutya ukutya kunye nokunyanya. Abanye baye bafika ekufowuneni iFTO ngokuthi "mastermind" xa kufikelele ekulawuleni i-genetic yokunyanya ukugqithisa nokuzimisela kwi-BMI ezayo.
Indlela i-FTO inokuthi "Vulela" ukunyaniseka
Iintlobo ezahlukeneyo zofuzo (cinga ngezi ngxaki "ezahlukeneyo zesigidi esisodwa esingazuza ilifa) se-FTO gene ziye zafunyaniswa ukuba zingabandakanyekanga kuphela ngokukhuluphala kodwa nangomhlaza kunye kwaye, ngokuphawulekayo, ezininzi iintlobo zomhlaza ukunyanya-kuhambelana , ngokunjalo.
Kwiimicebe, abaphandi baye baqaphela ukuba ukuphazamiseka okuthile kwintsebenzo ye-enzyme ehambelana ne-FTO inokuvula okanye ukucima ukutshintsha kwezinye iizakhi ezilawula umthamo. Oku, kunokubangela ukugcina amanqatha ngokungafanelekanga, okanye ukufumana "i-slowabetabolism." Oku kunokukhokelela kwi-Type 2 yesifo sikashukela, esinye isifo esichaphazelekayo.
Abaphandi baye bafumanisa ukuba ukuphathwa kweengingqi ezithile ze-FTO igugu kunokutshintsha isisindo somzimba kunye ne-metabolism kwiigundane, kubandakanywa indlela yokugcina i-fat-ngaphandle kokutshintsha kwintsebenzo yomzimba okanye isondlo.
I-Artictic Treatment Treatment
Nangona kungekho nonyango ephathekayo ekhoyo okwangoku ephathwa unyango, inzululwazi ithemba ukuba ukufumanisa okunjalo ngokofuzo njenge-FTO "i-gene gene" kuya kubakho kwiithagethi zonyango oluzayo. Ngaphambi koko, nangona kunjalo, kusekho okunye okuninzi okumele kufundwe malunga nokuveliswa kwe-fetes.
Imithombo:
Claussnitzer M, Dankel SN, Kim KH, Quon G, et al. I-FTO yokuthambisa ubukhulu bombane kunye ne-adipocyte i-browning kubantu. N Engl J Med ngo-Agasti 19. [Epub ngaphambi kokuprinta]
Liu C, Mou S, Pan C. Ijethi ye-FTO rs9939609 i-polymorphism ixela umngcipheko wesifo senhliziyo: ukuhlaziywa okucwangcisiweyo kunye nokuhlaziywa kwemeta. PLoS One 2013; 8: e71901.
I-Lombard Z, U-NJ, van der Merwe L, et al. Umdla wokulawula izityalo zegesi zidibaniswa nesalathisi somzimba kumntu osemnyama waseMzantsi Afrika: isifundo sombutho wezofuzo. I-BMJ Evuliwe ngo-2012; 2 (3).
Micali N, I-Field AE, i-JL ye-Treasury, i-Evans DM. Ingaba ubunzima bezilwanyana ezinobungozi obudityaniswe nokutya okudliwayo kwintsholongwane? Ubukhulu (iSicurity Spring) 2015; 23: 1729-36.
Smemo S, Tena JJ, Kim KH, Gamazon ER, et al. Iintlobo ezihambelanayo nomzimba ophezulu kwiFTO ifom yexesha elide uxhulumaniso olusebenzayo kunye ne-IRX3. Uhlobo lwe-2014; 507: 371-5.
Xi B, Zhao X, Shen Y, et al. Amashishini obunzima bokungcola aphezulu kunye nexinzelelo lwengqondo kubantwana baseTshayina. I-Int J Obes (Lond) 2013; 37: 926-30.
Zhao X, Yang Y, Sun BF, Zhao YL, Yang YG. I-FTO kunye nokukhuluphala: iindlela zobudlelwane. I-Curr Diab Rep 2014; 14: 486.