I-Psoriatic arthritis yinto engapheliyo yokuvuvukala kwe-arthritis . Iyakwazi ukuqhubela phambili ize ibangele umonakalo ohlanganyelweyo kunye nokukhubazeka. Ngokuqhelekileyo, i-psoriatic arthritis ithathwa njengeyinqabileyo, kodwa ixhaphake kakhulu kubantu abane-psoriasis, ezichaphazelekayo phakathi kwe-6-10% yezigulane ze-psoriasis. Kuxhaphake ngakumbi phakathi kwabo bane-psoriasis enamandla, echaphazela i-20-40% yeli qela lezigulane.
Kubalulekile ukuqaphela izinto ezinobungozi ezinxulumene ne-psoriatic arthritis. Umngcipheko ngumpawu okanye into eyenza ukwanda komntu uza kuhlakulela isifo okanye imeko ethile. Imiba yengozi ihlelwa njengento eguqukayo okanye engaguqukiyo. Ingxaki eguquguqukayo ingabonisa ithuba lokukhusela i-psoriatic arthritis okanye ukulawula umonakalo onokubangela.
Ukuchongwa kwemingcipheko ye-psoriatic arthritis yayifikile ngokukhawuleza. Kwakukho izifundo ezimbalwa zeengxaki ze-epidemiological ezavandlakanya iziganeko zengozi ye-psoriatic ukususela ngowama-2000. Kukho nezifundo ezimbalwa eziye zaphangela ingozi yokuvelisa i-psoriatic arthritis phakathi kwabantu abane-psoriasis. Abaphandi baye bakwazi ukugqiba ekubeni i-psoriatic arthritis inokuthi iqhutywe ngenxa yokudibanisa i-genetic, immunologic, kunye nemeko yengozi.
Genetic
Phantse i-40% yezigulane ezine-psoriasis okanye i-psoriatic arthritis zinamalungu entsapho ane psoriasis okanye i-psoriatic arthritis. Ucwaningo luye lwabonisa ukuba izigulane ezineenkcukacha zeentsapho ze-psoriatic arthritis zazingama-27-48 amaxesha amaninzi ukuphuhlisa eso sifo kunabangenayo imbali yentsapho.
I-Psoriatic arthritis ithathwa ngokuba "yinto efanelekileyo kakhulu" kunezinye izifo ezizimele .
Izingane zabazali nge psoriasis ziphindwe kathathu ukwandisa i-psoriasis kwaye zinomngcipheko omkhulu wokuphucula i-psoriatic arthritis ngokuthelekiswa nabantwana babazali ngaphandle kwe-psoriasis. Ukuba iwele efana ne-psoriatic arthritis, enye iwele efana nayo inokuba nayo isifo okanye ukuyihlakulela ekugqibeleni. Amagciwane amaninzi anxulumene nokuxhamla kwi-psoriatic arthritis nayo idibaniswa ne-susoriable to psoriasis. Kodwa, akubona zonke iizakhi ezidibeneyo nezifo zombini.
Immunologic
Amachiza omzimba amaninzi angabangela ukunyusa ingozi ye-psoriatic arthritis. Iiseli ze-T ezisebenzayo zikhoyo kwiisisiti zombini kunye namajoyina. Kwakhona kucatshangelwa ukuba ii- cytokines , ezifana ne-TNF-alpha, zidlala indima kwinkqubo yokuvuvukala ekhokelela ekubhubhiseni i-cartilage kunye nokuvuvukala kwesikhumba ehambisana ne-psoriatic arthritis.
Yendalo
Kukho imo engqongileyo ebonakalayo enxulumene nomngcipheko wokwenza i-psoriatic arthritis. Ukubonakaliswa kwezifo ezithile kuthathwa njengengozi, ingakumbi i-streptococcal infections. Ikhonkco ayizange iqinisekiswe okanye iqinisekiswe.
I-Psoriatic arthritis ixhaphake kakhulu kubantu abaye banesifo sengculaza yomntu (i-HIV) xa kuthelekiswa noluntu jikelele.
Isiganeko seKoebner, esenzeka kuma-52% abantu abane psoriasis ngokutsho kweKelley's Bookbook yeRheumatology, ithathwa njengenye into engqongileyo. Okokuqala echazwe nguDkt. Heinrich Koebner (i-dermatologist ehlonishwayo kakhulu ukusuka ngekhulu le-19) ngowe-1876, izilonda ze-psoriatic kwifom yangaphambili engenakuvuthwa emva kwexinzelelo lolusu. Yintoni eyenza umcimbi weKoebner awusacacanga kodwa i-cytokines, iiproteni zokuxinwa, i-molecule ezixhasayo kunye ne-autoantigens zingabandakanyeka.
Imithombo:
Ukuchongwa kweeMngcipheko zeArthritis Psoriatic: Inyululwazi yeNzululwazi ihambelana neemfuno zeCliniki. Ogdie noGelfand. JAMA Dermatology. Julayi 2010.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917977/
Ulwazi olunomonde: I-Psoriatic arthritis (Ngaphandle kweZiseko) Gladman noRitchlin. Isemgangathweno.
http://www.uptodate.com/contents/psoriatic-arthritis-beyond-the-basics
I-Psoriatic Arthritis. M. Elaine Husni. Kliniki yaseCleveland. Agasti 2010.
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/rheumatology/psoriatic-arthritis/
I-Koebner Phenomenon. Iiklinikhi kwiDermatology. Sagi L. noTrau H. Matshi-uEpreli 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21396563
I-Kelley's Bookbook yeRheumatology. I-ninth edition. Elsevier. Isahluko 77. IArthritis ye-Psoriatic. Oliver Fitzgerald.