Ngaba isidlo se-Gluten-Free Simahla Sinokunyamekela Izifo zikaLou Gehrig?
Abanye abantu abaneengxaki zeengxaki ze-neurological amyotrophic lateral sclerosis - eyaziwa ngokuba yi-ALS, okanye isifo sikaLou Gehrig-banamazinga aphakamileyo e-anti-gluten ejikelezayo emizimbeni yabo, ephakamisa umbuzo wokuba ukutya okunokutya kunokutya kunokunceda ekunyangeni isifo, isifundo sibonisa.
Nangona kunjalo, abaphandi abaqhuba isifundo baqaphele ukuba ukufunyaniswa kwawo kukuqala kwaye kufuneka kuqinisekiswe ngophando olungakumbi phambi kokuba oogqirha baqwalasele ukunyanga izigulane zabo ze-ALS ngeesidlo esingenanto.
Iingcali zenzululwazi, eziseTel Aviv Medical Centre e-Israel, okwangoku ziqhuba uvavanyo lokuhlola ukulandelwa kwemiphumo yokungena kwi-ALS kwizigulane ze-ALS ezine-antibodies ze gluten.
I-data esuka kulolu cwaningo ibonisa ukuba, kwiimeko ezithile, i-ALS syndrome inokudibaniswa nokuzimela komntu kunye nokukhathazeka kwe-gluten, "abaphandi babhala kwiphononongo, banyatheliswa ngo-Ephreli 2015 kwiphepha lezokwelapha i- JAMA Neurology . "Nangona idatha ingaphambili kwaye idinga ukuphindaphinda, ubuninzi be-gluten buya kunyangwa; ngoko ke, lo mngeni onokuxilonga awufanele unyathelekiswe."
Unyango lwe-ALS luya kubaluleka
I-ALS isifo esiqhubekayo se-neurological, ekugqibeleni iziphumo - ngokuqhelekileyo kwiminyaka embalwa yokuxilongwa - ekukhubazeni nasekufeni. Abantu abangaba-5 600 bafumaneka ukuba bane-ALS minyaka yonke e-US, kwaye imeko ixhaphake phakathi kweminyaka engama-40 no-60. Esi sifo kubangelwa ukungonakaliswa kwintambo yomgudu onomthwalo wokunyakaza.
Unokuba uqhelane nale meko evela kwintengiso enkulu eyenziwa ehlobo le-2014 yi-ALS Ice Bucket Challenge, eyayihamba ne-viral media media kwaye yakhulisa ngaphezu kwezigidi eziyi-100 ze-ALS ngenkxaso kunye nophando.
Ukufumana unyango lwe-ALS olunceda abanye abantu ukuba baphuculwe-nangona ukuba unyango lusebenza kuphela kwi-subset encinci kulabo abane-ALS-kuya kubaluleka.
Okwangoku, kukho esinye isicatshulwa esivunyelwe i-ALS, kwaye unyango lugxininisa ekunyuseni ukunyuka kweempawu xa kunceda izigulane zibhekiselele iimpawu zabo ngcono.
Eli akusihlandlo yokuqala ukuba iiklinikhi zicebise ukuxhamla phakathi kwesifo se-celiac kunye / okanye ubuninzi be-gluten no-ALS. Iingxelo ezibini ezipapashwe ngecala zichaza izigulane ezaqala ukuxilongwa nge-ALS, kodwa kamva ngubani oye wafumanisa ukuba unesifo esiqhekezayo kwaye iimpawu zakhe ziphuculwe xa zihamba zingenanto.
Nangona kunjalo, uphando olukhulu olupapashwe ngo-2014 aluphumelelanga ukufumana unxibelelwano phakathi kwesifo se-celiac, ngokukodwa, kwaye i-ALS ifunyaniswe.
Isifundo seTel Aviv sijonge ii-Antibodies ezingaqhelekanga
Uphononongo olutshanje olusuka kubaphandi base-Israel lubandakanya izigulana ezingama-150 ze-ALS ezifunyaniswe ngokulandelanayo phakathi kukaJulayi 2010 noDisemba 2012, kunye nezifundo ezili-115 zolawulo oluphilileyo ezibandakanywe ukuthelekisa.
Abaphengululi benza iimvavanyo zegazi ngenxa yamagciwane anesifo se-gluten anxulumene nesifo se-celiac kwaye yafumanisa ukuba akukho mntu wabanye kwiqela elinalo li-antibodies, oku kuthetha ukuba ngokuqinisekileyo babengenayo isifo se-celiac.
Abaphandi baphinde bafune uhlobo oluthile lwe-anti-gluten ebizwa ngokuba yi-IgA-Transglutaminase-6 (IgA-TG6), engabandakanyekanga kwisifo se-celiac.
Nangona kunjalo, i-IgA-TG6 idityaniswe kwezinye iinjongo kwi- gluten ataxia , imeko engenazo iinjongo zegazi ezinokuthi umzimba uphendule ekusebenziseni i-gluten ngokuhlasela i-neurons yayo. I-gluten ataxia ingakhokelela ekubalulekeni, ukukhubazeka okuqhubekayo kwiimeko ezinzima.
Uphononongo lufumene ukuba izigulane ezingama-ALS ezingama-23 - okanye i-15.3% - zinezikhuhlane eziphezulu ze-IgA-TG6 ze-gluten, xa kuthelekiswa ne-4.3% kuphela yezifundo zolawulo. Ukongezelela, malunga ne-59% yezigulane ze-ALS ezine-anti-gumen ziphethe ubuncinane ubuncinane besinye isifo sesifo esiqhekezayo .
Ezi zigulane ze-ALS ezinama-antibodies aseGigA-TG6 ezijikeleza kwiimida zazo zegazi zibonisa ukuba iqela libiza ngokuthi "umfanekiso weklasi we-ALS," efana nezigulane ze-ALS ngaphandle kwee-antibodies ze-gluten - ngamanye amazwi, oogqirha abazange bakwazi ukuxelela amaqela amabini .
Ngoko Kuthetha Kanjani Oku Konke?
Oku akucaci okwamanje. Njengoko ndibhalile ngasentla, abaphandi ababandakanyekayo kulolu cwaningo baqaphelisisa ngokungafundanga kakhulu kulo, nangona bavavanya ukuba i-gluten-free isenokunceda ukuphatha i-ALS, ubuncinci kwi-subset yabantu abane-anti-Igut-anti-gumen i-IgA-TG6.
Ukuba iziphumo zabo ziphinda zilandelwe, isinyathelo esilandelayo siza kuqhuba isilingo sekliniki ukuba sibone ukuba ukutya okunokutya okungenayo i-gluten kunokunceda izigulane ezine-ALS kunye ne-IgA-TG6. Izicwangciso zesifundo esinjalo ziyaqhubeka. Uphononongo lwethu lubonisa ukuba i-ALS syndrome ehambelana noveliso lwe-gluten inokuvela kwinqutyana yezigulane kwaye i-TG6 IgA autoantibodies ingaba ngummakishi wokuchonga izigulane ezinokukhathazeka, "abaphengululi baphetha.
Imithombo:
Brown KJ et al. Imiba engummhlophe icetyiswa nge-amyotrophic lateral sclerosis eyabangelwa zizifo ezinqabileyo. I-American Journal ye-Neuroradiology . NgoMeyi 2010; 31 (5): 880-1.
UGadioth A et al. I-Transglutaminase 6 Ama-Antibodies kwiSerum yezigulane nge-Amyotrophic Lateral Sclerosis. JAMA Neurology . Ishicilelwe kwi-intanethi ngoAprili 13, 2015
Ludvigsson JF et al. Akukho nhlangano phakathi kwesifo se-celiac esiqinisekisiweyo se-biopsy kunye ne-amyotrophic lateral sclerosis elandelayo I-European Journal ye-Neurology . 2014 Julayi; 21 (7): 976-82.