Isifo se-Parkinson sichaphazela ingqondo kunye neeseli zesiswini kwaye ngokuqhelekileyo kubangele iingxaki ngokuhamba kwemisipha; i-leukemia luhlobo lomhlaza ochaphazela umongo wegazi kunye negazi. Isifo sikaPasinson siqabile kakhulu kubantwana; ngelixa i-leukemia ngumdla wesiqhelo kakhulu ebuntwaneni. Ziyakwenza njani ezi zifo zimbini ezahlukeneyo?
Ewe, abantu abaneParkinson kunye nabantu abane-leukemia ngokuqinisekileyo baninzi kakhulu-umthwalo wokujongana nesifo sabo. Ngokomzimba, ke, iincwadi zenzululwazi zinika iimbalwa ezimbalwa ezikhokelela kuzo ezinokubangela umdla kubantu abafuna ukufana phakathi kwezi zifo zibini.
I-Leukemia Drug ibonakala ekunciphiseni iimpawu zeParkinson
I-Tasigna (nilotinib) yinyango evunywe ukunyanga iintlobo ezithile ze-leukemia. Ngokusekelwe kwiqela elincinci labafundi abathatha inxaxheba, i-nilotinib ibonakala iyanciphisa iimpawu kubantu abanesifo sika-Parkinson nesifo sengqondo sokugula komzimba okanye i-Lewy yokugula komzimba.
Ngokombiko we-NPR, ityala lezigulane ezili-12 ezinikezwa amanani amancinci ka-nilotinib zifumene ukuba ukunyakaza nokusebenza kwengqondo kuphuculwe kubo bonke abantu abali-11 abagqibelele iinyanga zenyanga ezintandathu. Abaphandi babika ezi ziphumo kuMbutho we-Neuroscience umhlangano waseChicago. Isifundo esincinci kakhulu, asizange senzelwe ukulinganisa ukusebenza kwaye akukho nto yokuphendula ngayo i-placebo effect.
Sekunjalo, ezi ziphumo zazibangel 'umdla kwaye ziza kwenza uphando olungakumbi.
U-Nilotinib ungoqela lezonyango ezibizwa ngokuba yi-kinase inhibitors. Ingakumbi ngokukhethekileyo, i-nilotinib iyisishibitor ye-BCR-ABL kinase. I-Kinases kunye nelinye iqela le-enzymes, i-GTPases, ayifaki nje kuphela kwiingxaki zeengqondo, kodwa ziye zadibana nezinye izifo zabantu eziquka umdlavuza kunye nezimo ezivuthayo.
Nangona iilisi zingenakulungiselelwa isifo sikaParkinson, akuyiyo into engacingi ukuba isingenangqiqo ukuba ingaba nefuthe elingenakulingelwayo le ngxaki.
Amanzi okuNxila aManzi aHlangeneyo kwababini
Uphando olupapashwe kwiphepha le-Agasti 2014 lephepha elithi "iMpilo yezeMvelo," lisebenzise ukuba ezinye zamanzi okusela e-US Marine Corps Base Camp Lejeune, eNorth Carolina, zazingcoliswa nge-solvent ngexesha le-1950 ukuya ku-1985. iqela labaphandi lihlolisise imiphumo yale ngozi ngokuziqhelanisa ngokubangela ukufa kwabasebenzi baseCamp Lejeune neCamp Pendleton, apho amanzi ahlambulukile.
Kunzima ukulungisa isizathu kunye nempumelelo xa ukhangela emva, kwaye iziphumo ezivela kulolu hlobo lwesifundo ziguqulelwa ngokuqaphela. Nangona kunjalo, kulolu cwaningo, kubonakala kunobungozi obukhulu bokufa okubandakanya izifo ezihlukahlukeneyo, kuquka nomhlaza wengqondo, i-leukemia, i-myeloma kunye nesifo sika-Parkinson phakathi kwabasebenzi abaye bavezwa kwiCamp Lejeune.
Ukubonakaliswa kweePasticides ezixhamle kwiZibini
Uninzi lweziganeko zesifo se-Parkinson kunye ne-leukemia zikholelwa ukuba ziphuhlise ngendlela ebeninzi, enokubakho ngeendlela ezahlukeneyo zokungqongileyo kunye neendidi ezininzi ezahlukahlukeneyo ezibandakanyekayo.
Ukufunda ukuphuhliswa kwezi zifo ngokubhekiselele kwinto enye, kwaye ukwenza oko kubukeka ngasemva ngexesha kunzima kakhulu. Nangona kunjalo, kukho inkxaso yonxibelelwano phakathi kwezilwanyana ezibulala izibulala-zinambuzane, i-herbicide kunye ne-toxins kunye ne-leukemia kunye nesifo sika-Parkinson. Ngokomxholo we-Meyi 2013 umagazini we- Neurology , iincwadi zenzululwazi zisekela i-hypothesis yokuba ukuchasana nezibulala-zinambuzane okanye i-solvents yinto engengozini ye-Parkinson, kodwa uphando olongezelelweyo luyimfuneko ukubonisa ubungqina kunye nobudlelwane. I-paraquat (paraquat dichloride, okanye i-methyl viologen), umzekelo, i-herbicide ebandakanyekile njengengxaki yobungozi be-Parkinson.
Ngokufanayo, iqela labaphandi eKosta Rica lizama ukufundisisa ubudlelwane phakathi kwabazali abaye batyhila kwi-pesticides kunye nomngcipheko we-leukemia yabantwana kubantwana babo. Nangona bekungenakukwazi ukungabandakanyi ukuba akukho nto ingabangela ukuba kubekho ininzi kwiindidi abaye bahlalutya ngazo, babone indlela yokunyuka kwengozi ye-leukemia yobuntwaneni kunye ne-pesticide-exposure-ngokukodwa ukuvezwa ngumama kwizibulala-zinambuzane ngexesha lokuqala kweesibini zokukhulelwa.
Imithombo:
Bove FJ, uRuckart PZ, uMaslia M, uLarson TC. Ukufunda ngokufa kwabantu abasebenzisana nabahlali abonakaliswe kumanzi okusela angcolileyo kwi-USMC Base Camp Lejeune: ukufundwa kweqela eliphindaphindiweyo. LeMpilo yeNdalo. 2014; 13: 68.
Cohn P, Klotz J, Bove F, Fagliano J. Ukuphuza amanzi kunye nokuhlala kwe-leukemia kunye ne-non-Hodgkin lymphoma. Ummeli wezeMpilo.
Monger P Wesseling C, Guardado J, et al. Ukuchazwa kwabazali kwiindawo zokubulala izibulala-zinambuzane kunye nomngcipheko we-leukemia ebuntwaneni e-Costa Rica. I-Scand J Umsebenzi weMpilo. 2007; 33 (4): 293-303.
Kamel F. Paths kwiitroticides ukuya kwi-Parkinson. Sayensi . 2013; 341: 722-723.
Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology kunye ne-etiology yesifo sikaParkinson: ukuhlaziywa kobungqina. Eur J Epidemiol . 2011; 26 (iSiza 1): S1-S58.
I-Pezzoli G, iCereda E. Ukuboniswa kwiidalwa ezibulala izibulala-zinambuzane okanye i-solvents nomngcipheko we-Parkinson. Neurology . 2013; 80: 2035-2041.
I-NPR. Ingaba I-Cancer Drug Reverse's Disvent Parkinson's and Dementia?
Hong L, Sklar LA. Ukujoliswa kweGTPases kwisifo sikaParkinson: ukuthelekiswa kwindlela yembali yokufumanisa iziyobisi kunye neembono. Imida kwi-Molecular Neuroscience . 2014; 7: 52.