Isikhokelo Esisisiseko kwi-NLPHL ukusuka kwiSimptomes kuya kwiNyango
I-lodphocyte ye-nodular eyinhloko yeHodgkin lymphoma (NLPHL) yintlobo yesifo seHodgkin , umhlaza weeseli ze-lymph . Ngenye yeentlobo ezingaphantsi kweHodgkin lymphoma , equka malunga nama-5% kuwo onke amacala alo mhlaza. Nangona kunjalo, inezinto ezininzi ezahlukileyo eziye zahlula kwezinye iintlobo zesifo seHodgkin esibizwa ngokuba yi-classical Hodgkin lymphomas.
Ngubani Ofumana I-Lymphocyte Engadliyo I-Hidgkin Lymphoma?
I-NLPHL inokwenzeka nanini na ubudala, nangona ezininzi izigulane zihlala zihlala kwii-thirties zazo. Kuphindwe kathathu ngokuqhelekileyo kwindoda ngokuthelekiswa nomyinge kubafazi. Akukho zizathu ezicacileyo, kodwa izinto ezinobungozi ziquka ukusuleleka kwintsholongwane ye-Epstein-Barr kunye nohlobo lwe-first-degree relative Hodgkin lympoma.
Ziziphi iimpawu ze-NLPHL?
Isibonakaliso esilona sihlandlo esibalulekileyo solu sifo sisandiso lweempawu zentlanzi entanyeni, esifubeni okanye emagqabini. Ukubandakanywa kwamanye ama-lymph nodes okanye ezinye izitho aziqhelekanga. Ezinye iimpawu ze-lymphoma ziquka umkhuhlane, ukulahleka kwesisindo kunye nokujuluka ebusuku. Uvavanyo lomzimba, imbali yonyango kunye nokuhlolwa kwegazi kuya kwenziwa.
Ukuxilongwa kwe-lymphoma kwenziwa nge- lymph node biopsy . Uhlobo oluthe ngqo lwe-lymphoma luchongwa yiimvavanyo zee-molecule ezingachaza umahluko phakathi kwe-NLPHL kunye nezinye iintlobo ze-Hodgkin lymphoma.
I-NLPHL ikhiqizwa yi-B-cells eziphazamisekile, eziqhelekileyo zenze inxalenye yesistim somzimba sokukhuselana nomzimba esivelisa izifo zamagciwane. Zineendlela ezihlukileyo ze-antigen ze-CD, iiprotheni ezingaphezulu kweeseli, ezivumela ukuxilongwa ngokusebenzisa uhlalutyo lwezinto eziphilayo kunye neemvavanyo ze-CD marker. Ezi ndlela ezikhethekileyo ze-antigen ze-CD nazo zisetyenziselwa unyango lwe-antioclonal antibody.
I-NLPHL ithathwa njani?
Phantse izigulane eziyi-8 kwezi-10 ezine-NLPHL zifunyaniswe ukuba ziqalwe kwinqanaba le-lymphoma , ezibandakanya i-lymph nodes kuphela entanyeni kunye nesigxina somzimba. I-NLPHL iyancipha ikhula kancinci kune-Hodgkin lymphoma yesiqhelo, kwaye ukuba ungenayo impawu kunokugqitywa ukuba ubukele kwaye ulinde iimpawu ngaphambi kokuqala unyango. Ukuba i-lymphoma isekuqaleni kwaye awunayo nayiphi na impawu ze-B ingaphathwa ngonyango lwamayeza kuphela. Izimpawu zeB zibandakanya umkhuhlane, ukulahlekelwa kwesisindo, kunye nokugungqa ebusuku.
Ukuba unempawu ze-B okanye imeko yakho isigaba esiphezulu, ngoko unyango lwe-nodular lymphocyte ephezulu i-Hodgkin lymphoma luquka i-chemotherapy kwaye i-radiation yonyango isenziwa ngokufanayo. I-antioclonal anti-rituximab inokunika uninzi Iigulane zisabela kakuhle kunyango, kwaye ngaphezulu kwe-90% yonyango. Amanani okusinda kwi-Hodgkin isifo siphucula ngenxa yokuqhubela phambili kunyango.
Nangona le nto ibonisa ukulungelelanisa kakuhle, kwi-10% ukuya kwi-40% yezigulane i-B-cell lymphoma enkulu eyenza i-b-cell i-lymphoma ikhula emva kweminyaka eyi-10 emva kokonyango. Njengoko i-NLPHL idla ngokuphindaphindiweyo kumadoda amancinane, kubalulekile ukuba baqhubeke belandelwa ixesha elide ukuze bafumane ukuphindaphinda. Nangona unyango lwabo lokuqala lubonakala luvelise unyango, iziganeko zokuphindaphinda kwakhona kunye nokuqhubela phambili kubalulekile kangangokuba zifuna ukubeka iliso ngokuqhubekayo ixesha elide.
Ukunyangwa kwezigulane ze-NLPHL eziphinda ziphinde zenziwe nge-rituximab, i-antibody monoclonal, ihlolisiswa.
Imithombo:
I-Cancer: Imigaqo kunye nokuSebenza kwe-Oncology 7th Edition. Abahleli: VT DeVita, S Hellman kunye ne-SA Rosenberg. Ipapashwe nguLippincott Williams noWilkins, ngo-2005.
> INational Cancer Insitution. Ukwelashwa kwe-Adult Hodgkin Lymphoma-kubafundi bezempilo (PDQ®).
> I-American Cancer Society. Ukunyanga i-nodular lymphocyte isifo esikhulu se-Hodgkin (NLPHD).