Amachiza amatsha ngokuphathelene ne-Placebo
Xa amachiza amasha efumaneka, kuyimvelo ukubuza ukuba ingafanisa njani ukuphumelela kwezo zonyango ezikhoyo. Kwimeko ye- Hetlioz , ithengiswa phantsi kwegama elithi generimette, kubalulekile ukuphonononga ukusetyenziswa kwayo ekuphatheni ukungabikho kwe-Hour-Sleep-Wake Disorder (engeyi-24) . Uthelekisa njani ne- melatonin , unyango oluqhelekileyo wale disorder?
Uphando oluPhando phakathi kweHetlioz noMelatonin
Akuzange kubekho iimvavanyo zophando lweeklinikhi ezithelekisa ukusetyenziswa kweHetlioz kunye ne-melatonin kwintloko yeentloko. I-US Food Management and Drug Administration (i-FDA) ivunyiwe iHetlioz ngokusekelwe kwiilingo ezilawulwa yi-placebo. Oku kuthetha ukuba i-Hetlioz, eyenziwa kwi-receptors kwingqondo ye-melatonin, yayiphumelele ngakumbi ekuphatheni i-Non-24 kuneepilisi ze-placebo. Ukusebenza kwayo akuzange kube ngokuthelekiswa ngokuthe ngqo ngokuthatha i-melatonin engaphezu kwe-counter-counter-ye-counter-counter-counter-the-counter.
Iziphakamiso ezimiselweyo unyango
Kwiikhokelo zalo zokugqibela ukususela ngo-2007, ngaphambi kokufumaneka kweHetlioz, i-American Academy ye-Sleep Medicine (AASM) uncoma ukusebenzisa i-melatonin kunyango lwe-Non-24. Ukuze kuzinze ukuveliswa kweengqungquthela ze-circadian ezibangelwa zizizukulwana ezingakhokelela ekuqhubeni ukulala nokulala kakhulu , i-melatonin inokusebenza kakuhle.
Oluzinzo lubizwa ngokuba yi-entrainment. Iingcamango zokulala nokuvuka kubantu abangaboniyo zingadibaniswa, okanye zingenele, kwiipateni zobusuku bemini.
Oku kunokufezwa ngamanani aphantsi kakhulu kwe-melatonin engaphezulu. Kubalulekile ukukhetha umenzi oncomekayo oqinisekisa ubungqinisiso kunye nokuchaneka kokubaluleka komkhiqizo.
Ngokuqhelekileyo, amanani amancinci (0.3 mg) angasetyenziselwa ukuqhuba abantu abangaboniyo abangama-24. Xa kuthelekiswa, iimveliso ezininzi zokuncedisa zihlala ziqukethe i-3 mg ye-melatonin (eziliqela ezili-10 ngokufunekayo) okanye ngaphezulu. Le melatonin engapheliyo inokukhukula inkqubo, iphikisana neenzuzo kwaye inokubangela iziphumo ezibi.
Ixesha le-dose le-melatonin libaluleke kakhulu. Ingadinga uncedo lugqirha lokulala ukuze kuqinisekiswe ukuba inani le dose kunye nexesha lifanelekileyo.
Ukuvavanya iziphumo zonyango
Uyazi njani ukuba unyango lusebenza? Ngaphandle kokuphuculwa kwesibonakaliso, kunokukunceda ukulandelela ukusebenza kwonyango kwezinye iindlela. Izigqoko zokulala kunye nemilinganiselo yebhubhoratri yamanqaku esigaba se-circadian anokunceda.
Kubaluleke kakhulu, kubantu abangekho abangama-24 abangaboniyo, ukukhanya okukhawulezileyo kokukhawuleza kungabakho unyango oluncedo.
Ngethemba lokuba uphando olungaphezulu luya kwenza ukuthelekiswa okuthe ngqo phakathi kweHetlio kunye ne-melatonin, kodwa ngelo xesha ungacinga ukuxoxa ngeendlela zokwenza unyango ngongcali wakho wokulala ukuze ubone indlela enokukhetha ngayo.
Imithombo:
Arendt, J et al . "Ukuvumelanisa ukujikeleza kokuphazamiseka kokulala ebuntwini oyimfama ngonyango lwe-melatonin." Lancet .
1988; 1: 774-773.
Morgenthaler TI et al . "Yenza imilinganiselo yokuhlolwa kweklinikhi kunye nokunyangwa kweengxaki zokulala zokujikeleza kwi-circadian: I-American Academy ye-Medical Medicine ingxelo." Ukulala . 2007; 30: 1445-59.
Lewy, AJ et al . "Iqondo elincinane, kodwa lingekho phezulu, i-melatonin yathintela umntu ongaboniyo osebenzayo ongekho sikhulu." I- Chronobiology International . 2002; 19: 649-658.
Tzischinsky, O et al . "Ukubaluleka kwexesha lokulawulwa kwe-melatonin kwindoda eyimfama." Umbhalo wophando lwepineal . 1992; 12: 105-108.
Isaka, uRL et al . "Ukuxhaswa kwee-circadian izhythms by melatonin kubantu abangaboniyo." UNJM .
2000; 343 (15) 1070-1077.
Ingxowa, uRL noLeyy AJ. "I-Circadian isigqirha sokulala kwesifo: izifundo ezivela kwimfama." Ukuhlolwa kweMithi yokulala . 2001; 5 (3): 189-206.