I-Dronedarone (i-Multaq) yicirrhythmic drug eyenzelwe ukunyanga i-fibrillation ye-atrial . Ekufuneni kwabo izixhobo ezikhuselekileyo nezichanekileyo kule meko, iinkampani zonyango ziye zacinga ngokucacileyo igrail yazo engcwele: isicatshulwa esisebenzayo njengama- amiodarone , kodwa ngaphandle kobutyhefu. I-Dronedarone yaveliswa nguSanofi (abenzi be-amiodarone) ngokukodwa kwithemba lokudala loo grail engcwele.
Impumelelo
Njengoko izidakamizwa zihamba, i-dronedarone isebenzayo ngokufanelekileyo ekuphatheni i-fibrillation ye-atrial. Ngelishwa, oku akuthethi kakhulu. Izilingo ezininzi zeklinikhi ziye zabonisa ukuba i-dronedarone iphumelela ngokufanelekileyo ekugcineni isingqimba esivamile kubantu abaye bafumana i-friday fibrillation.
Ngokukodwa, i-dronedarone iboniswe ukuba iyasebenza ngakumbi kune-placebo. Sekunjalo, ama-64% wezigulane ezaphathwa nge-dronedarone zaziphindaphindiweyo kwi-fibrillation yonyango ngexesha lonyaka wokuqala kunyango. Ngokwahlukileyo, i-75% yezigulane ezafumana indawo ye-placebo zaziphinda zifayibhile. Ukuphuculwa okuthobekileyo kufana nokunye okubonwayo kunye nezinye iziyobisi ezichasayo - kwakhona, akuthethi kakhulu.
Kwilingo leklinikhi ekuthelekeni nokusebenza kwe-dronedarone ukuya kuma-amiodarone, i-dronedarone yayingaphantsi kweli "mzali" wayo. Abantu abangama-64% abane-fibrillation ye-atrial ephathwe nge-dronedarone bebenokuphindaphindiweyo kwe-agrillation ngonyaka, xa kuthelekiswa "kuphela" abangama-42% abo baphathwa ngama-amiodarone.
I-Dronedarone iphihliwe kakuhle?
I-Dronedarone iyimvelaphi ye-amiodarone, eyona nto iyona ndlela iphumelelayo, kodwa ininzi inetyhefu, i-antiarrhymic drug. Ngokungafani ne-amiodarone, i-dronedarone ayinayo i-athomu ye-iodine. Kukholelwa ukuba i-iodine kwi-amiodarone ivelisa ezinye zezilwanyana ezinobungozi obunobungozi, ingakumbi inetyhefu ye - thyroid ebonwe ngedakamizwa mhlawumbi neyobisi yemiphunga .
Kwaye njengoko kuvela, i-dronedarone ayizange ibonise ububanzi obuninzi bezobisi ezinxulumene ne-amiodarone. Nangona kunjalo, ukuchazwa kwesibindi kuye kwabikwa nge-dronedarone, kwaye ezinye iimeko zesifo sotywala ziye zabonwa. Abantu ababenenkinga yesibindi okanye imiphunga kwi-amiodarone akufanele banikwe i-dronedarone.
Ucwaningo luye lwaphakamisa ukuba abantu abanesifo senhliziyo , okanye abaye bashiya amaqhezu ejection angama-35% okanye ngaphantsi, banokubeka ingozi yokufa xa bethatha i-dronedarone. UDronedarone akufanele isetyenziswe kubantu abanezi meko.
Ezinye iziphumo zempembelelo ze-dronedarone zibonakala zibuhlungu. Iimpawu eziqhelekileyo ezibiweyo zikarhudo okanye isicupunu, inqanaba lentliziyo elincinci, kunye nokukhawuleza.
Ngaphantsi
Njengazo zonke izidakamizwa ezichaseneyo, i-dronedarone kufuneka isetyenziswe ngokuqaphela. Ukusetyenziswa kwayo okucetyiswayo kukunceda ukugcina isisu esisigqirha kwizigulane ezineziqulatho ze-fibrillation ye-atrial . Ukuba i-fibrillation yonyango ibuyeka ngelixa ithatha i-dronedarone, isilwanyana kufuneka simiswe, kunye nesicwangciso esicwangcisiweyo sokwelashwa.
Isilwanyana sisetyenziswe kakuhle kubantu abancinci abaphethe i-fibrillation ye-atrial kuphela kunye nabanentliziyo enempilo.
Funda kabanzi malunga nokunyangwa kwefayilifayili yomhlaba .
ILizwi
Njengoko kuphelile, i-dronedarone ayikho i grail engcwele. Ewe, ibali kunye nale nkunkuma ibali elifanayo eliye lavezwa ngamaxesha amaninzi ngezidakamizwa ezichaseneyo - okokuthokoza kwangaphambili, okulandelwa kukudumala. Njengengqela, iziyobisi eziphambene nezidakamizwa zisebenza ngokukhawuleza, kodwa ziphakathi kwezilwanyana ezinobungozi kakhulu kwiyeza. Zifanele zisetyenziswe kuphela emva kokuqwalaselwa ngononophelo kwazo zonke iindlela, kwaye xa izibonelelo ezinokuthi zicacile zigqithise ngakumbi ingozi.
> Imithombo:
> I-Dorian P. I-Clinical Pharmacology KaDronedarone: Impembelelo Ngonyango Lwamafibhabhisano E-Atrial. J Cardiovasc Pharmacol Ther 2010; 15: 15S.
> Hohnloser SH, i-Crijns HJGM, van Eickels M, et al. Impembelelo ye-dronedarone kwimicimbi ye-cardiovascular in fibrillation. N Engl J Med 2009; 360: 668-678.
> Connolly SJ, Camm AJ, Halperin JL, et al. I-Dronedarone e-friday friday. N Engl J Med 2011; INGXELO: 10.1056 / NEJMoa1109867.