Ubungqina bokunciphisa ubunzima nokunciphisa ushukela wegazi
Ingaba ungumntu onesifo sikashukela iminyaka emininzi kwaye awukwazi ukulawula iswekile yakho kwakhona kumayeza omlomo? Isifo sikashukela sisifo esiqhubekayo kwaye ngamanye amaxesha ukulungiswa kwimizi yonyango kufuneka kwenziwe ukwenzela ukulawula iswekile yegazi.
Ngokuqhelekileyo, abantu abanesifo sikashukela banokuzuza ngokusebenzisa iyeza elinojojo (kungekhona i-insulin) ngaphezu kweyeza zabo zomlomo.
Amayeza angenayo i-insulin, ebizwa ngokuba yi-GLP-1 agonists (njenge-Byetta kunye no-Victoza), aboniswe ukuba bancede banciphise emva kokutya kwegazi kunye nokunciphisa ubunzima.
Yintoni i-Bydureon?
Enye i-GLP-1 agonist, i-Bydureon, ifom yexesha elide le-Byetta enikwa kanye ngeveki. I-Bydureon yi-GLP-1 (i-peptide-ye-glucagon-like peptide 1) i-agonist evuselela ukufihla kwe-insulini xa idibana ne-glucose.
Kuye kwaboniswa ukugcina umsebenzi we-beta cell (iiseli ze-beta zenza i-insulin) kwaye ziye zafakazela ukukhuthaza ukulahleka kwesisindo ngokulibazisa isisu sokukhupha nokunyusa iimvakalelo zokuzaliseka. Ucwaningo luye lwabonisa ukuba abantu bathatha iYydureon balahlekelwa umyinge wama-pounds amahlanu ngeenyanga ezintandathu zokuthatha amayeza kwaye baye baboniswa ukuba bayigcine ngeminyaka emithathu.
Uphando olutsha olwenziwa ngu-AstraZeneca (abanikazi be-Bydureon) lubonisa ukuba ukuxilwa kwangoko-veki yokumiswa kwe-autoinjection kunokuba kuncitshiswe kakhulu kwi-HbA1c (-1.4 vs -1.0) kunokungeniswa kwe-Byetta kabini ngosuku.
Izigulane kwiqela le-autoinjection kunye neqela lakwa-Byetta lalinokunciphisa okufanayo kumzimba womzimba (-1.5 kg vs. -1.9 kg, ngokulandelanayo; p-value = 0.4).
Olunye uphando lubonise ukuba xa kuthelekiswa ne-insulin, izigulane zisebenzisa i-Bydureon zilahlekelwa ubunzima-isisombululo esizimeleyo sokulawula ishukela segazi.
Control Blood Sugar Control
Nangona iilingo zeklinikhi zibonisile ukuba unyango nge Bydureon lunokunceda ukunciphisa i-A1c malunga neepesenti eziyi-1.5, i-Bydureon ayisetyenziswanga njengonyango wokuqala wesifo sikashukela. Esikhundleni saloo nto isetyenziswe njengesilathisi sesibini okanye yesithathu ngokudibanisa ne- metformin okanye i-sulfonylurea.
Ukuba uthatha i-sulfonylurea, i-dose yakho ingadinga ukulungiswa ukunciphisa umngcipheko we- hypoglycemia . I-Bydureon kufuneka isetyenziswe ngokudibanisa nokutya kunye nokuzilolonga kwaye ayifuni ukuba isetyenziswe njengesilwanyana sokulahlekelwa kwesisindo.
Kuthatha i Bydureon
Ngaphambili, i-Bydureon yayifumaneka kuphela isebenzisa isirinji eyayikude kwaye inzima. Nangona ijojo yayisisodwa ngeveki, abanye abantu bakhononda ngokungahambi kakuhle. Nangona kunjalo, ngoku i-Bydureon ikhona ukusetyenziswa ngokusebenzisa ipeni. I penti inokuthi ikhululeke kwaye ilula ukuyisebenzisa ngaphandle kwesirinji.
I-Bydureon ifanele ijojowe ngaphantsi kwimizimba enamafutha kwaye ingabi sisisipha okanye isisu. Unokuyijoza i-Bydureon kwiindawo ezifanayo unokuthi usebenzise i-insulin-isisu (ezimbini intshi kude nesisu sakho), amathanga angaphandle, izimpembelelo zezandla zakho ezingaphezulu. Unokusebenzisa indawo efanayo kwiveki, jonga nje ukuba ungasebenzisi indawo efanayo.
Ngamanye amaxesha abantu baziva bexakeka okanye babomvu kwisayithi yokujova.
Shayela umnini-nkonzo wakho wezempilo ngokukhawuleza ukuba unentlungu ebuhlungu, ukuvuvukala, i-blisters, isilonda esivulekile, okanye isalathisi emnyama kwisayithi lakho lokungena.
Ngubani Okhethiweyo weBydureon?
Xoxa nomboneleli wakho wezempilo ukuba ungumgqatswa weBydonon. I-Bydureon ayithethi ukuba isetyenziswe njengesilwanyana sokulahlekelwa kwesisindo kwaye isetyenziswa ngokubambisana namanye amayeza e-diabetes. Ukuba ungumntu onentsholongwane yesifo sikashukela esingu-2, ogama lakhe lishukela iinjongo kwaye unokukwazi ukulahlekelwa ubunzima , kunokuba i-Bydureon inokukhetha.
Ngubani Akufanele Awathathe iYydureon?
Kwizifundo zezilwanyana, i-Bydureon yabangela iifos ukuba zihlakulele izicubu ze-thyroid gland.
Ngako oko, i-Bydureon inqatshelwe kwizigulane ezineenkcukacha zomntu okanye intsapho yomdlavuza we-thyroid (MTC) kunye nezigulane ezine-Multiple Endocrine Neoplasia syndrome hlobo 2 (MEN 2). Abantu abanokuvakalelwa ukuba baphumelele okanye nakweyiphi imveliso yomsebenzi akufanele bathathe i-Bydureon.
Ngaphambi kokuba uthathe i-Bydureon, kufuneka uxelele umniki wakho ukuba unembali ye-pancreatitis, amatye kwi-gallbladder yakho (gallstones), imbali yobunxila, okanye amanqanaba aphezulu e-blood triglyceride njengoko i-Bydureon ingenakucingelwa kuwe. Xa uthatha i-Bydureon, ukuba unesihlungu esiswini esingahambi, kufuneka uqhagamshelane nomboneleli wakho wonyango ngokukhawuleza njengoko oku kungabonakalisa ukuphazamiseka kwe-pancreatitis. I-Bydureon ayifanelekanga kwizigulane ezine-type 1 zeswekile.
Ngaba Le Yona Yodwa Ngamayeza Angenayo Yamayeza Kanye?
Okwangoku, i-Bydureon yimizuzu kuphela yeveki ekhuselweyo ngeyeza. Kodwa, ezinye iinkampani zisebenza kwiimimiselo kwaye ziqhuba iimvavanyo zeklinikhi. I-Bydureon imane nje isiqalo sokuthengiswa kwemarike yeswekile.
Imiphumela
Ngenxa yokuba i-Bydureon ilibazise ukukhupha isisu, iziphumo eziqhelekileyo ziquka ukuncwina nokuhlanza. I-casino iqhuma ngokuqhelekileyo xa kuqala ukuqala imishanguzo kwaye iyancipha ngaphezu kwexesha xa umzimba usebenzise iyeza. Ezinye iziphumo ezichaphazelekayo zibandakanya intloko, isifo sohudo, ubomvu kwisayithi yokujova.
> Imithombo:
> Wysham, uCarol, kunye. al. I-DURATION-NEO-1: i-HbA1c enkulu yokunciphisa ngokumiswa kwangaphandle kwiveki nganye nge-autoinjector ipen vs exenatide kabini imihla ngemihla ngokungafanelanga ukulawulwa kwesifo sikashukela. Septemba 29, 2014.
> Ahren, B & Schmitz, O. GLP-1 i-agonists ye-receptor kunye ne-DPP-4 inhibitors ekwonyango uhlobo lwesifo sikashukela. IHorm Metab Res. 2004 ngoNovemba-Dec; 36 (11-12): 867-76. NgoSeptemba 24, 2014.
> Reid, Timothy, MD. Ukukhetha ii-agonists ze-GLP-1 okanye i-DPP-4 inhibitors: ezilinganisa ubungqina bekliniki. Umbutho weSwekile waseMelika. Septemba 25, 2014.
> Ulawulo lwezoKutya noLawulo lweeDrug. I-Bydureon yeMicrosoft Guide . Septemba 25, 2014.