I-Compazine, i-Thorazine, kunye ne-Reglan ye-Migraine i-Attracks ne-Nausea
Ingaphezu kwesigamu sabantu bahlakulela isicupunu kunye nokuhlanza ngexesha lokuhlaselwa kwe-migraine. Ekubeni i-neurotransmitter dopamine ibandakanyekile njengomlamli omkhulu we-nausea ngexesha le-migraine, imishanguzo evimba i-dopamine receptors (ebizwa ngokuba ngabaphikisi be-dopamine) iyasebenza ekunciphiseni isicupunu kunye nokuhlanza. Kuyathakazelisa ukuba ezi antimetics nazo zinciphisa intlungu ye-migraine, kwaye ngoko ke isetyenziswe rhoqo njengonyango lonyango ekwenzeni imigraines enzima.
I-Compazine kwi-Treatment Migraine
I-Antipsychotics efana neCompazine (prochlorperazine) isetyenziselwa ukuphatha i-migraines ezinzima kunye ne-nausea ehambelana nayo.
Ukongezelela ekuphatheni izibilini ezinomsoco kunye nokuhlanza, iCompazine isetyenziselwa ukonyango lwe-schizophrenia kunye nokunyangwa kwexesha elifutshane lokukhathazeka okungapheliyo kwengqondo. I-Compazine ifumaneka njengamacwecwe, iifomsile ezikhutshwe ngokusisigxina, ifom ye-liquids yomlomo, i-suppositories kunye neengqayi-ezinikezwa nge-intravenously (nge-vein) okanye nge-intramuscularly (kwi-muscle). Ngenxa yobunzima bemilomo yomlomo kunye nesicathulo sokuhlanjululwa kwe-migraine kunye nokuhlanza, iCompazine inikezwa nge-intravenously okanye nge-intramuscularly ukwenzela ukukhulula impawu-ngokuqhelekileyo kwigumbi elingxamisekileyo, kwiziko lokunakekelwa ngokukhawuleza, okanye kwiklinikhi.
Imiphumo emibi yeCompazine ibandakanya ukulala, ukuxakeka, ukujonga umonakalo, ukusabela kwesikhumba, uxinzelelo lwegazi oluphantsi kunye ne-amenorrhea. Iimpembelelo ze-Extrapyramidal zinokuthi zenzeke njengama-spasms e-muscle, ukungazinzi, i- parkinsonism , okanye i-dyskinesia ye-tardive.
Isisombululo esingaqhelekanga kodwa esinokusongela ubomi kwiCompazine (kunye nezinye i-antipsychotics) yi-Neuroleptic Malignant syndrome, ebangela iimpawu ezahlukahlukeneyo kuquka imfiva, ukuqina komzimba kunye nokudideka.
I-Thorazine kwi-Treatment Migraine
I-Thorazine (i-chlorpromazine) ngenye indlela i-antipsychotic isetyenziselwa ukuphatha imigraines ekhuselekileyo kunye ne-nausea kunye nokuhlanza.
NjengaCompazine, kaninzi kunikezwa ngokusesikweni okanye ngokunyanzeliswa kwe-migraine kunye nesisulu somnxeba. Ngokwezibonelelo zalo, ngokutsho kwe-2013 kwi- Journal of Emergency Medicine , iTrarazine yaphucula intlungu yesifo, isisonguluko, kunye nobuthakathaka ekukhanyeni nasezithebeni kubantu abane-migraine xa kuthelekiswa nabantu abathabatha indawo ye-placebo (i-saline infusion). Kodwa kulolu cwaningo, abantu abaninzi babelala ukulala nokuzondwa xa besuka xa bethatha iTrazine, xa kuthelekiswa nabantu abafumana i-placebo.
Reglan kwi-Treatment Migraine
I-Reglan (i-metoclopramide) ikhusela i-dopamine receptors. Kodwa ngokungafani nezinye i-antipsychotics, isetyenziselwa ukwandisa i-gastric motility kubantu abanengxaki yokukhupha isisu, njengabantu abanesifo sikashukela. Efana neCompazine, i-Reglan iphinda isetyenziswe ukuphatha i-migraine-nausea kunye nokuhlanza, ngokukodwa kwigumbi loxinzelelo okanye ukunyamekela ngokukhawuleza, kwaye kuyasebenza. Enyanisweni, olunye uvavanyo luka-2013 lweCornrane luye lwafumanisa ukuba ukuhlanganiswa kwe-Reglan kunye ne-aspirin kwandise ukuhlanjululwa kwe-migraine-kunye nokuhlanza kunye nemiphumo emibini emalunga ne- triptan Imitrex (i-sumatriptan).
Nangona i-Reglan idla ukuba nemiphumo embalwa ngaphandle kwezinye i-antiemetics, eziqhelekileyo ziquka:
- ukungazinzi
- ukhathala
- ukungcola
- intloko
- kudideka
- iingxaki zokulala
NjengeCompazine, nangona kunjalo, iziphumo ezimbi ezinjengeempawu ze-extrapyramidal kunye ne-Neuroleptic Malignant Syndrome zinokuvela (ezinqabile kakhulu). Kwakhona, i-Reglan inokunyusa umngcipheko womntu wokudandatheka kunye neengcinga zokuzibulala.
Okukwintsusa
Ukuxutywa kwe-migraine kunye nokuhlanza, imithi evimba i-dopamine receptors kwingqondo (i-dopamine antagonists) isetyenziswa ngokuqhelekileyo, ngakumbi i-Compazine, iTrarazine, okanye i-Reglan. Nangona kusebenza kakuhle, la mayeza ayenomngcipheko. Qinisekisa ukuxelela ugqirha ukuphatha zonke iingxaki zempilo kunye neyeza, kuquka iivithamini, izongezelelo, kunye neengcali zonyango.
Imithombo:
Bigal ME, Bordini CA & Special JG. Intravenous chlorpromazine kwiphondo loncedo lotyando lwe-migraines: ityala elilawulwa ngokungahleliwe. Jemerg Med . 2002 Aug; 23 (2): 141-8.
I-Flake ZA, i-Linn BS kunye ne-Hornecker JR. Ukhetho oluchanekileyo lwe-antiemetics kwisimo sokubhabha. I-Fam Famician 2015 Mar 1; 91 (5): 29306.
ULáinez M JA, García-Casado A & Gascón. Ulawulo olufanelekileyo lwezonyameko ezinkulu kunye nokuhlanza kwi-migraine: ukuphucula iziphumo zesigulane. Isigulane seMiphumo yeziPhulo . 2013; 4: 61-73.
US Food and Drug Administration. Isikhokelo seMithi: iCompazine. Kufikeleleka ngoFebruwari 4, 2016.
US Food and Drug Administration. Isikhokelo seMithi: Reglan (i-metoclopramide injection). Kufumaneka ngoFebruwari 5 ka-2016.
INKCAZELO: Ulwazi olukule ndawo lusezinjongo zemfundo kuphela. Akufanele isetyenziswe njengendawo yokunyamekelwa ngumntu ogqirha. Nceda ubone ugqirha wakho ukuze ufumane unyango kunye nonyango malunga nayiphi na impawu okanye imeko yonyango .