I-Acromegaly yintlupheko ye-hormonal apho kukho ukwanda kwe-hormone yokukhula. Ukuba ukuphazamiseka kukuqala ekufikeni komntwana, kuthiwa yi-gigantism.
Uninzi lweziganeko ze-acromegaly zibangelwa i-tumor (non-cancerous) ye-tumor ye-pituitary gland kwingqondo. I-tumor ikhiqiza i-hormone yokukhula ngokweqile, kwaye njengoko ikhula ixhomekeka kwiisishu zeengqondo ezijikelezileyo.
Uninzi lwezi zihlamba zenzeke ngokukhawuleza kwaye azizuzi njengefa.
Kwiimeko ezimbalwa, i-acromegaly ibangelwa i-tumor kwenye indawo emzimbeni, njengemiphunga, i-pancreas okanye i-adrenal glands.
Iimpawu
Ezinye izicubu zikhula ngokukhawuleza kwaye zivelise i-hormone yokukhula encinci, ngoko i-acromegaly ayibonakali iminyaka emininzi. Ezinye iimvumi, ngakumbi kubantu abatsha, zikhula ngokukhawuleza kwaye zivelise i-hormone enkulu yokukhula. Iimpawu ze-acromegaly zivela kwi-hormone yokukhula kunye nokuxineka kwe-tumor kwiisishu zeengqondo, kwaye zingabandakanya:
- Ukukhula okungavamile kwezandla kunye neenyawo
- Utshintsho lwezinto zobuso: i-brow ebonakalayo, umhlathi ophantsi, neempumlo; umlomo omkhulu nolwimi
- Arthritis
- Intloko
- Ubunzima bokubona
- Ikhumba elincinci, elibi, elinamafutha
- Ukunciphisa okanye ukuphefumula ukuphefumula ngelixa ulele (ukulala nge-apnea)
- Ukuphosa nokukhupha isikhumba
- Ukukhathala nobuthathaka
- Ukwandiswa kwezitho ezinjengebindi, ipeni, izintso, intliziyo
I-Acromegaly ingabangela nesifo sikashukela , uxinzelelo lwegazi oluphezulu kunye nesifo senhliziyo.
Ukuba i-tumor ikhula ebuntwaneni, i-gigantism ibangelwa ukukhula kwethambo elingavamile. Umdala omdala ukhula kakhulu (kwimeko enye, ukuya kwii-intshi ezili-9 ubude ubude).
Ukuxilongwa
Ukuvavanya izinga lokukhula kwehomoni egazini ngexesha lovavanyo lomlomo lwe-glucose ukunyamezela luhlobo oluthembekileyo lokuqinisekisa ukuxilongwa kwe-acromegaly.
Oogqirha banokulinganisela amanqanaba egazi enye ihomoni, ebizwa ngokuba yi-insulin-like growth factor I (IGF-I), elawulwa yi-hormone yokukhula. Amanqanaba aphezulu e-IGF-ndidla ngokubonisa i-acromegaly. Ukusebenzisa i-computed tomography (CT) okanye i-imagination magnetic resonance imaging (MRI) yeengqondo, oogqirha banokukhangela i-tumor pituitary ukuba i-acromegaly iyaxelwa.
Unyango
Utyando lwe-acromegaly lujoliswe ku:
- Ukunciphisa amanqanaba okukhula kwehommone eveliswayo
- Ukunciphisa ingcinezelo yokuba isisu se-pituitary sinokubeka iicyunu zengqondo
- Ukunciphisa okanye ukuguqula iimpawu ze-acromegaly.
Iindlela eziphambili zonyango zi:
- Ugqirha ukususa i-tumor-pituitary - kwiimeko ezininzi, unyango olunempumelelo.
- Amachiza okunciphisa umlinganiselo we-hormone yokukhula kunye nokunciphisa i-tumor - iProlodel (bromocriptine), iSandostatin (octreotide), kunye neSomatuline Depot (lanreotide).
- Uphulo lwe-radiation - ukulahla izicubu ezingenakususwa ngokupheleleyo ngokuhlinzwa.
- Iimithi ezivimbela imiphumo ye-hormone yokukhula kunye nokwehlisa i-IGF-I-Somavert (pegvisomant).
Uphando
Abaphandi eYunivesithi yaseFederico II yaseNaples e-Italy bafunde abantu abangama-86 abane-acromegaly abaye banikwe unyango ngaphambi nangemva kokususwa ngokukhawuleza (ukuhlengahlengiswa) kwezicubu zabo.
Bafumene ukuba ukuthengiswa kwe-75% ye-tumor-secreting tumor kuphuculise impendulo kumachiza. Uphando lwapapashwa kwimiba kaJanuwari 2006 yeNcwadi ye-Clinical Endocrinology & Metabolism .
Imithombo:
> Mhlobo, KE "I-Acromegaly: unyango olutsha." Ulawulo lweCancer: Umbhalo we-Moffitt Cancer Centre 9 (2002).
> "Acromegaly." Ulwazi malunga ne-Endocrine kunye neMetabolic Diseases. NgoMeyi 2008. Isiko seSizwe seSifo sikashukela kunye neNtsholongwane kunye neeNtsholongwane zeNtliziyo.