Ukuba uthabatha nge-weekly ye-interferon, unombulelo kumthi wamakhemikhali. Oku kungenxa yokuba ngaphandle kwekhemistry ye-pegylation kufuneka ujobe i-interferon ukuya kathathu ngeveki. Ngamafutshane, i-pegylation yenza ukuba amayeza akho alula kwaye empeleni yenza kube ngcono.
Sibanzi
I-intergyon ye-Pegylated, ngokuqhelekileyo ibizwa ngokuba yi-peginterferon, ifom ye-interferon eqhelekileyo eyenza i- hepatitis C kwaye ayifumanekanga i- hepatitis B.
Umahluko phakathi kwe-interferon kunye ne-peginterferon yi-PEG, emele i-molecule ebizwa nge-polyethylene glycol. I-PEG ayenzi nto yokulwa nentsholongwane. Kodwa ngokuyifaka kwi-interferon (elwa ne-virus), i-interferon iya kuhlala emzimbeni (ngokukodwa igazi) ixesha elide.
Le nkqubo inceda izigulane ze-hepatitis zithatha i-interferon kuba kunokufuna ukufaka injini ye-interferon ukuya kwiihlandlo ezintathu ngeveki, kufuneka ijokeki enye kuphela ngeveki. Ukongezelela, ivelisa izinga eliphakamileyo lokuphendula nge-virologic .
Kukho iinguqulelo ezimbini ze-peginterferon, ezithengiswayo njengePegasys (eyaziwa ngokuba yi-peginterferon alfa-2a) kunye ne- PegIntron (eyaziwa ngokuba yi-peginterferon alfa-2b). Bobabini banamanyathelo afana ne-pharmokokinetic, kunye neentlukwano ezincinci phakathi kwababini.
Ukusebenza
Ngaphambi kokusungulwa kwama-anti-virus (DAAs) ngokukhawuleza ngo-2013-okubandakanya iziyobisi zikaSovaldi , iHarvoni , iDadlinza kunye ne- Viekira Pak , phakathi kwabanye-indlela efanelekileyo kakhulu yokunyanga i-hepatitis C yayinokudibanisa ne-peginterferon kunye ne- ribavirin .
Ulwaphulo oluninzi luyaziwa ngokuba negalelo eliphezulu lemiphumo yonyango, ezinye zazo ezinokuba zinzulu. Sekunjalo, ulwalamano oluhlangeneyo lukwazi ukuphumeza impendulo eqhubekayo ye-virologic (inkcazo yeklinikhi yokunyanga) malunga nama-50 ekhulwini amatyala.
Namhlanje, nge-DAA entsha yeklasi, ukusetyenziswa kwe-peginterferon kuye kwawa kakhulu, nangona ngamanye amaxesha kusekho umyalelo kwizifo zesifo esibindileyo kunye / okanye kwizigulane eziye zahluleka ukunyanga.
Lawulo
I-Peginterferon ijojowe kanye ngeveki. I-dose echanekileyo iya kuhluka ngohlobo lwezinto ezinje, kuquka i- genotype ye-virus yakho , uhlobo lwe-peginterferon oluya kulusebenzisa, kwaye izilwanyana ezihamba kunye nazo ziya kulawulwa kunye nazo. Umongikazi wakho uya kukufundisa indlela yokuphatha kakuhle ijojo, ngokuqhelekileyo ngaphantsi (kwinqaba). I-Peginterferon kufuneka ihlale ifriji, kwaye inaliti akumele isetyenziswe okanye isabelo.
Imiphumela
Iziphumo ezisecaleni ze-peginterferon ziyahlukahluka kumntu ukuya kumntu, kunye nabanye abantu abalawulayo baya kuba neziganeko ezimbi kakhulu xa abanye bebona iimpawu abazicingelayo. Iziphumo eziqhelekileyo ezichaphazelekayo nokusetyenziswa kwe-peginterferon zi:
- Izimpawu ezinjenge-Flu (intloko yesifo, umkhuhlane, amahlwitha, ama-acry aches)
- Ukungabikho
- Ukudandatheka nokuguquka kwemizwelo
- Ukutshatyalaliswa
- Isihlunu kunye nokuhlanza
- Utywala
- Ukukhathala okukhulu
- Ukuphelelwa kwesidlo
- Ukuhla ukusinda
Izigulane zonyango ziza kuthethwa ngeRuba Rage, imeko ebonakaliswa ukungaxhatshazi ngokubanzi kwaye ngezinye izikhathi, ngezinye izihlandlo eziphazamisayo zengqondo. Nangona eli gama libonisa imbangela yi-ribavirin, ngokuqhelekileyo idibene ne-peginterferon. Ngandlela-thile i-Anti-depressants imiselwe ukuba ilawule imeko, ingakumbi kwizigulane ezineengxaki ze-psychiatry zangaphambili.
Iindleko
Inkqubo epheleleyo yeyeza ye-peginterferon iyabiza kodwa ngenhlanhla, nge-DAA yeklasi elitsha, ubude bonyango bufutshane kakhulu kunaphambili.
I-Medicaid, i-Medicare kunye ne-inshurensi yabucala iya kubandakanya iindleko ze-interferon xa unyango lwe-hepatitis C luvunyiwe. Ukuhlawulwa kwe-Co-pay can be searched by the manufacturer of drugs for patient patients, kwakunye neenkqubo zokuncedisa isigulane (PAPs) kwizigulane ezingafumanekiyo okanye ezingenayo imali.
Ukungqinelana
Abanye abantu abane-hepatitis C akufanele bathathe i-peginterferon. Ezi zibandakanya abantu abaneemeko ezilandelayo:
- Isibindi esiphezulu, intliziyo, isifo okanye imiphunga
- Ezinye izifo ezizimele
- Ukudakumba okukhulu okanye ezinye izimo zengqondo
- Ukukhulelwa
- Ukuncelisa
Njalo qiniseka ukuba ugqirha wakho unembali yakho epheleleyo yonyango, kuquka ulwazi malunga naluphi na olunye unyango olungapheliyo unakho (umzekelo, i- HIV , isifo sikashukela) okanye naziphi na izicwangciso onokufuneka uzikhulelwe.
Imithombo:
Katzung, BG. I-Basic and Clinical Pharmacology, 10e. ENew York, kuMcGraw-Hill, ngo-2007.
UBrenner GM, uStevens, uCW. Pharmacology, 2e. Philadelphia, Saunders Elsevier, 2006.
Genentech. "I-Pegasys: eziphambili zeNgcaciso yoLwazi . "
Merck. "I-PegIntron: eziphambili zeenkcukacha zoLwazi."