I-antigen ye-Cancer 27.29 (i-CA 27.29) yonyango lwegazi olwenziwe ngokukhethekileyo kubantu abanomdlavuza wesibele. Ingomnye wamanqaku omhlaza wesifo somhlaza ongasetyenziselwa ukubeka esweni isikolo sesifo. Enye inguqu yolu vavanyo ibizwa ngokuba yi-"truquant BR radioimmunoassay test."
I-CA 27.29 yi-antigen-oko kukuthi, uhlobo oluthile lweprotheni olukhoyo kummandla weeseli kwaye luveliswa ngumzimba othiwa yi-MUC-1.
I-CA-27 "i-glycoproteins," (i-glyco ithetha iswekile) kwaye inokuthi ibe khona phezu kwamaseli e-epithelial afana neeseli zomhlaza zesisu. Iiseli zomhlaza zesifuba zinokukhupha iikopi zeprojekthi ze-CA 27.29 ukuya kwigazi.
Igazi I-CA 27.29 imilinganiselo ngokuqhelekileyo ingaphantsi kwe-40 U / ml. Ngomdlavuza, amazinga e-Ca-27 anganyuka, ixabiso eliphakamileyo, ngakumbi kunokwenzeka ukuba oku kungabonisa ukuba khona komhlaza.
Sibanzi
Inokukunceda ukuphula iindlela ezahlukeneyo zokuhlolwa kwe-biomarker ye-CA 27.29:
- Ukuxilongwa-Olu vavanyo alisoloko lwenziwa ukuba luhlolisise umdlavuza webele , ubuncinane bodwa. Kukhankanyiwe apha ukunika ingqalelo ukuba uvavanyo lwe-CA 27.29 luphela luvavanyo lwamazi olusetyenziswa ngokukhethekileyo ukucacisa ubukho beeseli zomhlaza zesisu. Ukuba unayo okanye ucinga ukuba unokuqala umdlavuza webele, le mvavanyo ingenziwa ukwenzela ukuba uncede uhlolwe.
- Ukubeka iliso unyango-Uvavanyo lwe-CA 27.29 luvame ukunyamekela ukuphendula impendulo yakho kwizonyango zomhlaza zesisu . Ukuba amazinga akho aphakama, kunokubonisa ukuba umhlaza wakho ubuya okanye uphuthuke, kwaye kungenokwenzeka ukuba ulungelelanise unyango lwakho ngokufanelekileyo. Ukuba amanqanaba akho awela, ingabonisa ukuba unyango lwakho luphumelela ngokubulala umhlaza wakho.
- Ukujonga ukuphindaphinda kwangaphambili-Ukuba unyango lwakho lomhlaza wesisu sele lugqityiwe, lo vavanyo lwenziwa rhoqo kwixesha eliqhelekileyo ukufumana ukuphindaphinda kokutsha komhlaza wakho. Ukuphakama kwe-CA 27.29 kwenzeka, ngokuqhelekileyo, malunga neenyanga ezintlanu ngaphambi kokuphindaphinda kubonakala ngokusekelwe kwiimpawu okanye kwizifundo zokucinga. Nangona kunjalo, kusekho impikiswano malunga nokuba ingafumani ukuphindaphinda komhlaza ngaphambi kokuba iimpawu zenze umehluko kunyango kwaye, ekugqibeleni, isiphumo sesi sifo.
- Ukujonga umhlaza wesifo se-metastatic (ukuhlolwa kwesimo) -Uvavanyo luya kunceda abo abanomdlavuza webele we-metastatic bayazi ukuba umdlavuza wabo uyaqhubeka. Oko kwathiwa, amazinga aphakamileyo anokuhlala ixesha elide kwaye, kwiphando elithile, amaphesenti angama-30 abantu ayenamanqanaba aphakamileyo aqhubekayo kwiinyanga ezimbini ukuya kwethathu emva kokuqala kokonyango olufanelekileyo.
Olu vavanyo alukhuthazwa njengendlela yokujonga umhlaza wesifuba , okanye njengendlela yokuxilonga umdlavuza webele, yinto engaboniyo into yokuba izazinzulu zibhekisela njengexabiso lokuqikelela.
Ngaphezu koko, oogqirha bahluka ngokugqithiseleyo kwizenzo zabo zokuyalela lo vavanyo. Abanye oogqirha bagxininisa ukuvavanya, kanti abanye bahlala becwangcisa rhoqo.
Imida
Kubalulekile ukuqaphela imida yokuhlolwa kwe-CA 27.29. Ekujongeni unyango lwe-metastatic-breast disease-indlela oku kusetshenziselwa ngayo le mvavanyo-kubalulekile ukuphinda uqaphele ukuba amanqanaba aphezulu e-CA 27.29 aqhubekeka kwiinyanga ezintathu emva kokuba unyango lugqityiwe.
Ngamanye amagama, ukuba uvavanyo luyenziwe emva kweenyanga ezimbalwa emva kokugqiba unyango, amanqanaba ayenokuphakama nokuba uyaphendula kakuhle kunyango.
Ekubeni uvavanyo lwe-CA 27.29 luphela luvavanyo olusetyenziswa ngokukhethekileyo ukufumanisa ubukho beeseli zomhlaza zesisu, kubonakala ngathi kuya kulandelwa ngokuphindaphindiweyo ukukhangela umdlavuza wesibele.
Nangona kunjalo, njengoko kuphawulwe, uvavanyo alukho xabiso lokuqikelela ekuqaliseni ubukho bomhlaza wesibeleko.
Ixabiso elifanelekileyo lokubikezela libhekisela kwimeko yokuba unesi sifo xa uvavanya ukuba unesi sifo. Kukho iimvavanyo ezininzi kwiyeza ezinokubonakala zinengqiqo njengendlela yokuphonononga isifo, kodwa kusezifundo, ukungabi nokuchaneka ukwenza umehluko kwimilinganiselo yokusinda.
Umlinganiselo wokugqibela xa uvavanyo lusetyenziswa ukufumana ukuphindaphinda. Kukhona ingxoxo eninzi malunga nokuba ukufumana ukuphindaphindiwe komhlaza wesifuba kusenokuba nokwenza umehluko. Ngethuba, ekuqalekeni, kubonakala ngathi kuya kuba neenzuzo kulo mkhuba, uphando alufumananga ukuba amazinga okusinda aphucula xa kuphinda kufumaneke umdlavuza wesifuba kusasa.
Ingxenye yokudideka ixhomekeke kwiinjongo zonyango lokuqala lomhlaza wesisu ngokubhekisana nomdlavuza webele we-metastatic. Ngethuba lokuqala lomdlavuza webele, iinjongo ngokuqhelekileyo ukunyanga kwesi sifo ukuze unyange umhlaza (okanye ubuncinci ukuwugcina ungabuyi.) Kodwa unyango olusisigxina, alukho umgomo wesifo somhlaza wesifo se-metastatic (nangona oku kungatshintsha kwikamva elikufutshane) njengoko kungabonakali ukwenza ummahluko kwizinga lokusinda. Kunoko, iinjongo kukuba ngokuqhelekileyo zisebenzisa umlinganiselo omncinci wonyango onokwenzeka ukulawula eso sifo.
Mngcipheko
Uvavanyo luvavanyo lwegazi olulula ke ngoko ingozi incinci. Izingozi ezinokuthi zibandakanye ukuxhalaxana kunye novavanyo oluqhelekileyo okanye umphumo wokuvavanya ongakhange ubonise ngokuchanekileyo isimo somhlaza wakho.
Ekubeni lo vavanyo lwenziwa nje kuphela njengengxenye yomdlavuza wokulondoloza, umngcipheko kaninzi awukhathazeki kakhulu. I-CA 27.29 ayiyilo vavanyo olugqibeleleyo, kodwa ludla luncedo kunye nezinye iimvavanyo, ezifana nokucinga, ukuphonononga ukuphindaphinda nokuphendula unyango.
Iingxaki zeZiko eliphakamileyo le-CA27.29 kwiiNtsholongwane ezingezange-Breast Cancer
Ezinye i-cancer, kunye neemeko ezinobungozi, kunokubangela izinga eliphakamileyo le-CA 27.29. Iintsholongwane ezingabangela umphumo ophakamileyo ziquka:
- Umhlaza wemiphunga
- Umhlaza wesifo
- Umhlaza wePancretic
- Umhlaza weColon
- Umhlaza we-ovari
- Umhlaza weprostate
Imiqathango ye-Benign engakhuphula i-CA 27.29 ibandakanya:
- I-ovarian cysts
- Iimeko zesifuba saseBenign zebele kunye neentso
- Izifo zesibindi, ezifana ne-cirrhosis-kwisifundo esinye, ngabantu abaphakamileyo be-CA 27.29 kodwa bengenayo umdlavuza, imbangela yayiyi- cirrhosis 25 yeepesenti yexesha
Ukongeza kwi-CA 27.29, kukho ezinye iimpawu zokuxuba ezingasetyenziselwa ukujonga umhlaza wesifuba. Ezi ziquka:
I-KI-67 ayisetyenziswanga ukujonga umhlaza wesifuba.
Uninzi ngokuqhelekileyo, okanye uvavanyo lwe-CA 27.29 okanye uvavanyo lwe-CA 15-3 liya kulawulwa, kodwa kungabini bobabini.
ILizwi
I-CA 27.29 ingasetyenziselwa iinjongo eziliqela ezahlukahlukeneyo ngomhlaza wesifuba kwaye yiyo enye i-biomarker esetyenziswe ngokukhethekileyo ukucacisa ubukho beeseli zomhlaza zesisu. Oko kwathiwa, kukho ezinye i-cancer kunye neemeko ezinobungozi ezingakhokelela kumazinga aphakamileyo.
Kwakhona kubalulekile ukuqonda imida yokuvavanya xa isetyenziselwa ukuhlola umdlavuza webele. Kwaye kufuneka uvavanyo luhlale lusetyenziswa kunye nezinye iziphumo, ezifana nokuhlolwa ngokomzimba, ukuhlolwa kwegazi kunye nezifundo zokucinga.
Isishwankathelo, ukubaluleka kwalolu vavanyo kubasetyhini abanomdlavuza wesibeleko kukuba kunokubonelela ngolwazi kwaye kukukhokele kunye nodokotela wakho ukuba:
- Impendulo yakho kunyango
- Isimo somhlaza wakho
- Ubunokwenzeka bokuphindaphinda kwangoko
> Imithombo
> I-American Society of Clinic Oncology. Ii-Biomarkers ukukhokela unyango lwe-Canast Metastatic Breast Cancer. Julayi 2015.
> Poznak, C., Somerfield, M., Bast, R. et al. Ukusetyenziswa kwee-Biomarkers ukukhokela izigqibo malunga neNyango yokuXhonywa kweNkxaso yabasetyhini abane-Metastatic Breast Cancer: I-American Society ye-Clinical Oncology Clinical Practice Guideline. Umbhalo we-Clinical Oncology . 2015. 33 (24): 2695-2704.