Iimeko ezithile ezizimeleyo zibizwa ngokuba ngezinye izifo "ezingabonakaliyo" izifo. Umntu ofumana i-flare engenzi-mali angabonakali ukugula kwangaphandle kwabanye; kunjalo, yena ubhekene nobunzima obuguqukayo emzimbeni kwaye unzima ukuqhubeka. Ngokutsho kukaDkt. Bonnie Feldman, umseli weDrBonnie360-Ukuqhagamshelana kwakho ngokuzimela, kuthatha iminyaka eyi-3.6 kunye noogqirha abangama-5 ukuba bafikelele kwi-autoimmune diagnostic.
Ngokuqhelekileyo, abantu banikwa igama elibanzi, elingachazwanga lomqathango kunye neempawu ezizenzekelayo.
Oku kuthetha ukuba abantu abaninzi bahlala kwimingcipheko iminyaka emininzi ngaphambi kokugqitywa ngokufanelekileyo. Nangona kunjalo, kwizigulane ezininzi-kwaye kukho ama-250 000 amatyala amatsha ngamnye ngonyaka-ukufumana ukuxilongwa ngokufanelekileyo kukuphela kohambo olude. Unonyango olulinganayo lwezonyango luhlala lubonisa uphawu kwaye lithembele kwiziyobisi ezingasoloko zisebenza ngendlela ehlala njalo kunye / okanye zineempembelelo ezingathandekiyo. Ngenxa yoko, abaninzi abantu baya kwiindlela zokudibanisa. Ngokomzekelo, ukutya kuvela njengendlela yokwenza imimiselo nokunyusa izinga lobomi bomntu.
Ezinye iingcali zikholelwa ukuba izixhobo zedijithali kunye nobuchwepheshe bezobugcisa zingabangela ukuba kubekho unyango olungcono kwizigulane ezinezifo ezizimele. I-teknoloji inokudibanisa iintlobo ezahlukeneyo zezigulane ezizimele (kuneemeko ezingaphezu kwe-100 ezihambelana phantsi kwe-umbrella) kunye nokuvumela ukwabelana kwedatha.
I-teknoloji ingakwazi kwakhona ukukunceda ukwakha ibhuloho phakathi kweyory and practice. Imibutho efana noDrBonnie360 ihlose ukudibanisa iteknoloji yedijithali kunye nokufunyaniswa kwenzululwazi yakutsha kunye nokuguqulwa kwendlela yokuphila ukuze abantu abahlala nezimo ezizimeleyo bakwazi ukukhulisa impilo yabo.
Umgudu njenge-Autoimmune Organ
Uphando olutshanje lugqithise ibhodlo njengelungu eliphambili lomzimba wokuxhatshazwa komzimba, ubuchopho kunye namayeza ezinokuhlala kunye nathi. UProfesa uMichael Kosiewicz weYunivesithi yaseLouisville, onomdla okhethekileyo wokuphanda ngokuzimela kunye ne-microbiota, wapapasha amanqaku amanqaku kulo mbandela, kubandakanya enye ichaza ubudlelwane obuyinkimbinkimbi phakathi kwama-bacterial gut and development of other diseases. Uchaza ukuba ukusebenzisana phakathi kwe-microbiota yegulane kunye neeseli zamasosha omzimba zidlala indima ebalulekileyo ekuphuhlisweni kweemeko ezivuthayo, njengezifo ezizimelayo kunye nezofo.
Lo mbono usengumntwana; Nangona kunjalo, kungenelelo oluninzi oluphuhliswayo olujolise kumathunga kwaye luhlala lubandakanya utshintsho lokutya kunye nokunciphisa uxinzelelo. Ukubandakanya izigulane, izixhobo zedijithali zinokukunceda kakhulu kwaye zikuncede utshintsho lokuziphatha, kunye nokuncedisa ukutya kunye neendlela zokuphila eziyimfuneko ukuze zibuyiselwe. Iintlawulo ezipheleleyo ze-fecal nazo ziba yinto enokubaluleka kwabanye abantu abanezifo ezivuthayo. Le nyango isele isetyenziselwa ukusulela iiCdirecty infections kunye ne-Irritable Bowel Disease (IBD). Kulindeleke ukuba iinkqubo ezifanayo ziza kuphuhliswa kwezinye iimeko ezinxulumene ne-microbiota.
Ukujonga kwiNkcazo eSebenzayo yeZifo eziMzimbeni
Inkulumo ye-TEDx ka-2011, eyanikelwa nguDkt. Terry Wahls, yaqalisa ingxoxo malunga nokunyangwa okupheleleyo kwezifo ezizimele. U-Wahls, onokuxilongwa kwe-multiple sclerosis (MS), wabonisa ukuba iingxaki zokuzimela komntu kufuneka ziqwalaselwe kumgangatho weselula. Wazinikela ekuhlolisweni kwesayensi yesifo sakhe, kwaye ngenxa yoko, waphucula imeko yakhe. Ngelo xesha, wenza lo bulwazi lufumaneke kuwo wonke umntu. Izigulane ezininzi zagqiba ekubeni zilandele ukukhokela kwakhe ngokufikelela kwiintetho zee-intanethi nakwiimpapasho. U-Wahls wenza icebo-protocol-elibizwa ngokuba ngu-Wahls protocol-ejolise ekuncedeni okunokondla kunye nokuguquka kwendlela yokuphila, kwaye yena kunye nabalingani bakhe benza uphando oluqhubekayo ukuqinisekisa nokuphuhlisa ngakumbi.
Batshanje ukwenza uvavanyo olusandululwanga olungenamsebenzi olubonakalisa ukutya kwe-Paleolithic kunokuphucula ukukhathala, umgangatho wobomi kunye nomsebenzi ohamba phambili wesandla kubantu abanobuninzi be-sclerosis. UDkt. Wahls kunye neqela lakhe bakholelwa ukuba ukutya kwe-Paleo kufuneka kuthathelwe ingqalelo njengokwenza unyango lwe-multiple sclerosis kwaye lisetyenziswe ngaphezu kweminye imithi ekhoyo.
Ezinye iingcali ezizimeleyo zibonisa ukuba ukuqonda imbangela engundoqo yeengxaki ezizimeleyo, izigulana kufuneka zinikeze idatha yazo kwaye zisebenze ekufumaneni iindima eziqhelekileyo ezinokuthi zibhekiselele kwisizathu.
Ukubonakaliswa koBomi beeSayensi (i-TLS) yinkampani eyaziwayo ukukwazi ukwabelana ngolwazi. Isebenzisa izicwangciso zokusasazeka kunye nokuvula izinto ezintsha kwaye kaninzi kunako ukunciphisa iindleko zokuvavanywa kwezonyango ngokuqwalasela ingeniso yesigulane. Isicwangciso esinye isibonelelo senkampani sifaka iilingo ezintle. Oku kunciphisa isidingo sokutyelela amasayithi eekliniki kwaye kusenza wonke umntu athathe inxaxheba. I-TLS ineeprojekthi ezininzi zophando eziqhubekayo, ezivela ekuhloliseni ukwamkelwa kwe-telemedicine kwizigulane ezine-IBD zokufunda imiphumo ye-lisinopril (i-ACE inhibitor) kwizigulane ze-MS.
Ukubhala Ukuphumelela Nokunika Ithemba
Nangona abaninzi banokucinga ukuba izifo ezizimeleyo ziphilwanga, baninzi abanye bafuna ukuphucula kakhulu imeko yabo emva kokuba baqalise ukutshintsha kwezinto ezithile zobomi. Ezi zihlandlo zihlala zibhekwa njengama-anecdotes, ezingabikho naluphi na uhlobo lwesayensi yolwazi. I-teknoloji yedijithali inokunceda ukurekhoda nokufunda abantu abaphumeleleyo kwaye bayisebenzise njengezifundo zecala ezinokuthi ziqiniseke iindlela ezithile zokuphatha izimo ezizimeleyo.
Ukuba abantu abaphuculweyo bayaphononongwa ngokwesayensi, izazinzulu ziyakwazi ukuba zeziphi iindlela zokwenza unyango olufanelekileyo. Ngelishwa, zifundo ezimbalwa ezicwangcisiweyo kunye nezicatshulwa ngokufanelekileyo ziye zaqhutywa ukuza kube yimini. Uphando malunga nokuzimela ngokubanzi luye lwahlukana phakathi koluntu oluhlukeneyo, ngoko ke ludinga ukuba inxalenye ehlangeneyo idlulele iintlobo ezahlukeneyo zokungena kunye nokuzisa ulwazi olufanayo. UDkt. Martha Herbert waseHarvard Medical School unxusa ugqirha lwentlalo ukuba lihlolisise imozulu kunye nesondlo sabantwana abazithobileyo ngokunyamekileyo, kunye nokufumanisa ukuba kutheni kwenzeka ukuba abantu bafumaneke. Umsebenzi wakhe ugxile kwiingxaki ze-thyroid kunye ne-autism (eye yadibaniswa nokuvuvukala komzi) kwaye ihlola indima yeeprotheni zokutya ngokuzimela. Ngokuqokelelwa kwedatha, izicwangciso zokulungisa izixhobo ezizimeleyo ziza kufunyanwa kwaye ziqhutywe phambili.
> Imithombo
> I-Irish A, u-Erickson C, u-Wahls T, u-Snetselaar L, u-Darling W. Ukuhlolwa kokuhlolwa kweengxaki zokuhlaziywa kwe-Paleolithic yokungenelela kwindlela yokutya ekunyangeni ukubuyiswa kwakhona kwe-sclerosis ezininzi: isifundo somqhubi. Izifo ze-Neurological and Neuromuscular Disease , 2017; 7: 1-17.
> Kamada N, Seo S, Chen G, Nunez G. Indima ye-microbiota yegciwane kwisifo sokuzikhusela kunye nokuvuvukala. Ukuhlolwa Kwemvelo Immunology , 2013; 13 (5): 321-335.
> Kharrazian D, Herbert M, Vojdani A. I-Immunological Reactivity esebenzisa ii-Antioclonal ne-Polyclonal Antibodies ze-Sites ezijoliswe kwi-Thyroid Target ngeProteins. Umbhalo woPhando lwe-Thyroid, ngo- 2017
> Kosiewicz M, Chhabra A, Alard P, Dryden G. Ulwalamano phakathi kwe-micro microota kunye nokuphuhliswa kwezifo ezihambelana neeseli. I-FEBS Letters , 2014; 588 (22): 4195-4206.