I-osteoarthritis ibizwa ngokuqhelekileyo njenge-arthritis yokugqoka kunye nokuphunga. Nangona kunjalo, abaphandi ngoku bafumanisa ukuba akukona ngokupheleleyo malunga ne-cartilage egugile. Kukho ezinye iindawo zomzimba ohlangeneyo, njengethambo le-subchondral, edlala indima ebalulekileyo kwi-osteoarthritis.
Yintoni i-Bone subchondral?
I-subchondral bone ithambo lesithambo ngaphantsi kwe- cartilage edibeneyo.
i--chondral ibhekisela kwi-cartilage, ngelixa isalathisi sendlela esezantsi. I-subchondral bone ithoxisa ngokuxakeka kwamalungu amaninzi.
Inemizila emininzi yegazi inikezela ngezondlo kunye ne-oksijini kwaye ithathe ama-waste. Njengoko i-cartilage ayinayo igalelo layo legazi, ubudlelwane obusondeleyo nesithambo se-subduondral sisisigcina isondlo esondla. Ezi nqanawa zinika isiqingatha se-hydration, i-oxygenation kunye ne-glucose ye-cartilage. Impilo kunye nomsebenzi wethambo le-subchondral liza kwenza umehluko kwimpilo ye-cartilage ephezu kwayo.
Yintoni eyenzekayo kwi-Osteoarthritis
Kwi-osteoarthritis, ithambo le-subchondral liba likhulu kunexesha eliqhelekileyo. Ubu bungqina bokuba ukuqina kuyenzeka ngaphambi kokuba i-cartilage ye-articular igqitheke-ibonisa ukuba ithambo le-subchondral lidlala indima ekuphuhliseni i-osteoarthritis. Izifundo ziye zafumanisa ukuba ngaphambi kokuba i-osteoarthritis ikhule apho kunokunyuka izinga lokubuyiswa kwethambo le-subchondral, njengoko lilinganiselwe ngu-scintigraphy.
Enye inqubo ibangela ukuba ithambo livuselelwe ukuze liphule kwaye lizilungiselele. Oku ngokwemvelo kukhupha izinto ezininzi ngeemveliso zelo metabolism ekunikezeni igazi okondla ithambo kunye ne-cartilage.
I-subchondral bone of attrition i-flattening or depress of surface articular.
Kubonakala kwintshontsho ye- knee osteoarthritis kwaye ubukho bayo buxela ukuba ukulahleka kwe-cartilage kuya kuphuhliswa kwaye nokuba ingaba igumbi lokuguqa liya kuba necala. I-subchondral bone bone i-edema-like lesions kunye ne-subchondral bone attrition zibonwa ndawonye. Enye inkolelo kukuba ukugqoka kunye nokugqabhuka emadolweni kubangele i-micro-fractures ehlala kwindawo yokulungisa. Lo msebenzi uvelisa i-enzyme kunye neeprotheni ezinokuba neziphumo ezingakumbi kwi-cartilage esondeleyo.
Abaphandi baye bafumanisa ukuba i-subchondral bone tissue ivelisa ama- cytokines amaninzi kunye nokukhula (iiprotheni) ezinokubangela ukuvuvukala kunye nokutshintsha kwimizimba yomzimba. Yintoni eyenzekayo kwaye yintoni na iikhemikhali ezinokuba yizona zijongene nazo zifuna uphando olungakumbi. Ingaba ukutshintsha kwethambo le-subchondral yintoni ekuveliseni ukulahleka kwe-cartilage okanye ukuba bayayilandela yini umbuzo wenkukhu-okanye-iqanda ukuze uphando olongezelelweyo. Yiyiphi eyokuqala? Ngaba enye inkqubo iyaqhuba kokubili? Ingaba kukho konke okubangelwa ukugqoka nokudiliza okanye kukho enye imbangela ebalulekileyo?
Ezinye iimeko ze-Bone Subchondral kwi-Osteoarthritis
- I-Subchondral Cyst : Oku kudla ngokubonakala kwi-osteoarthritis, isigxoba esigcwele amanzi esiya kwi-joint. Kuyinto eqhelekileyo ukufumana kwi-X-ray kodwa ayifuni ukucinywa okanye olunye unyango.
- I-Subchondral Sclerosis : Oku kwandiswa kwexinzelelo lweethambo okanye ukunyusa kwi-subchondral layer, ebonwe kwi-X-ray ye-osteoarthritis. Ngenye yeembonakaliso ze-radiographic yale mqathango.
Imithombo:
> Iimpawu zezinto eziphilayo kunye neengcingo zesithambo se-subchondral kwi-osteoarthritis. Biorheology. 7/26/2004. I-Radiology yophicotho: Oktobha 2000 - Umqulu 35 - Inkcazo 10-iphe 581-588
Rheumatology yanamhlanje. Umqulu 13, Inani 1. Matshi 2003. http://www.springerlink.com/content/j0d9m9yak10085hc/
UFrank W. Roemer, kunye. al. "Izilonda zamathambo zesigxina zamathambo zidibanisa kakhulu, kwaye ziqikelele ukuba i-subchondral bone of attrition longitudinally: MOST study." I-Osteoarthritis Cartilage 2010 Jan; 18 (1): 47. Ishicilelwe kwi-intanethi ngo-2009 Sept Sep 10. i-doi: 10.1016 / j.joca.2009.08.018