Yintoni eyenza ihluke?
I-Zorvolex yile dolo ephantsi, ifom ye-diclofenac, i- NSAID (izidakamizwa ezichasene nezidakamizwa). Kuvunyiwe ukuba unyango lwe- osteoarthritis buhlungu ngo-2014. Yintoni eyenza ihluke kwezinye iindidi ze-diclofenac kunye nezinye ii-NSAID?
I-Zorvolex, eveliswe yi-Iroko Pharmaceuticals, LLC, yavunywa ngokusemthethweni ukuze yonyango lwabadala kubantu abahluphekileyo.
Ukuvunyelwa kweentlungu ze-osteoarthritis yinkcazelo eyongezelelweyo, ekubeni ingekho yonke imishanguzo kunye nonyango iphumelela ngokufanayo nawuphi na umntu onikezelweyo, wamkelwa njengendlela entsha yokufumana izigulane ze-osteoarthritis.
Iintlobo zeDiclofenac
I-Zorvolex ihluke njani kwi-diclofenac yesiqhelo kunye nefom yegama legama, i- Voltaren , yindlela ye-diclofenac, kunye ne-diclofenac? I-Zorvolex yenziwe nge-submicron i-diclofenac. Iincinci ze-submicron zingama-20 amaxesha amancinci kunobungakanani obufumaneka kwezinye iyeza zediclofenac. Iincinci ze-submicron, eziphunyeziweyo zisebenzisa i-SoluMatrix Fine Particle Technology, vumela ukuba izidakamizwa zichithwe ngokukhawuleza. I-Zorvolex yinto yokuqala ye-dose NSAID (i-nonsteroidal anti-inflammatory drug) ephuhlisiwe esebenzisa iSoluMatrix Fine Particle Technology evunyiwe yi-FDA.
Kufuneka ii-NSAID eziphantsi kweeDose
I-NSAID ye-dose ephantsi inceda ukujongana neengcebiso kunye neengcebiso ze-FDA.
Kwiminyaka emininzi edlulileyo, i-FDA ihlaziywe kwaye ikhupha izilumkiso kuzo zonke iziyobisi ze-NSAID. Kwacaciswa ngokucacileyo ukuba ii-NSAID zidibene nomngcipheko ophezulu weengxaki zentliziyo (umz., Ukuhlaselwa kwintliziyo kunye nesifo) kunye nokuphuma kwegazi kumzimba . Ngelo xesha, ezimbini ze-COX-2 ze-NSAID ezikhethiweyo-i- Vioxx (rofecoxib) kunye ne- Bextra (valdecoxib) - zatshitshiswa kwiimarike, kodwa ezininzi zahlala.
I-FDA ikwacetyiswa noogqirha ukuba bayinike (kwaye izigulane zizisebenzise) i-dose ephantsi kakhulu ye-NSAID ngexesha elifutshane kunokwenzeka, ngelixa liqwalasela ingqwalasela yomgomo.
Ulawulo / Isistim
Isilinganiso esinconywayo seZorvolex (isilonda somlomo) seentlungu ze-osteoarthritis singama-35 mg. kathathu ngosuku. (Qaphela: iifomsile ze-Zorvolex azizitshintshi kunye ne-Voltaren okanye iipilisi ze-diclofenac eziqhelekileyo. Isilinganisi kunye namandla angalingani.) Zorvolex 35 mg. i-capsule eluhlaza okwesibhakabhaka kunye ne-IP-204 eprintiweyo emzimbeni kunye ne-35 mg kwi-cap in inkino emhlophe.
Ukuthatha iZorvolex ngokutya kunokunciphisa ukusebenza-ayizange ifundwe. Kwakhona, izigulane ezinezifo eziziwayo (isibindi) zingadinga ukulungiswa kwemilinganiselo.
Izimpembelelo eziqhelekileyo
Ngokusekelwe kwizilingo zonyango, iziganeko eziqhelekileyo ezichaphazelekayo ezinxulumene neZorvolex ziquka i-edema, isicupunu, intloko yesisu, isisu, ukuhlanza, ukuqhwaba, i-pruritis, isifo sohudo, ukunyanzelisa, intlungu, kwimilenze, ubuhlungu besisu, sinusitis, ukwanda kwe-ALT (alanine aminotransferase), ukwanda kwegazi creatinine, ingozi yexinzelelo, kunye nokunyanzelisa.
Ukungqinelana
Izigulane ezingafanele zithathe iZorvolex zibandakanya: abo abane-hypersensitivity eyaziwayo kwi-diclofenac; izigulane ezine-asthma, imihlathi, okanye nayiphi na indlela yokuphendula emva kokuthatha i-aspirin okanye nayiphina i-NSAID; kunye nabo baneentlungu ezihambelana nombhoxo we-coronary bypass operation.
Izilumkiso kunye nokuqapha
Izilumkiso eziqhelekileyo ezihambelana nazo zonke ii-NSAID, ngokubhekiselele kwengozi eyongezelelekileyo yeziganeko zentliziyo kunye nezilonda zamathumbu kunye nokuphuma kwamanzi, nazo ziyasebenza kwiZorvolex. Ukulumka kufuneka kusetyenziswe ukuba izigulane ezinomlando wangaphambili wezilonda zamathumbu okanye ukuphuma kwegazi zichazwe ngeZorvolex. Ukuhlolwa kwegazi ngenxa yomsebenzi wesibindi kufuneka kwenziwe rhoqo ngezikhathi ukujonga ukungaqhelekanga. Izigulana ezithatha i-Zorvolex nazo zimele zibekwe iliso ngenxa yomshukela ophezulu, ukugcinwa kwamanzi, i-edema, kunye neentsholongwane . I-Anaphylactoid kunye neempembelelo ezininzi zesikhumba nazo zinokwenzeka.
I-Zorvolex ayifanele ithathwe nge-aspirin ekubeni ukwenza njalo kuya kwandisa umngcipheko wokuphuma kwegazi.
Ngokufanayo, iZorvolex akufanele ithathwe ngama-antiticoagulants kuba nayo iya kwandisa ingozi. Ukuba sele sele uthatha i-ACE inhibitor, i-diuretic, i-lithium, i-cyclosporine, okanye i- methotrexate , kufuneka isetyenziswe kuba ukusebenzisana kwezidakamizwa kuya kwenzeka.
Kubafazi abakhulelweyo, izifundo zezilwanyana zityhila ukuba iZorvolex ingabangela ingozi kumntwana. Emva kweentsuku ezingama-30, isilwanyana akufanele sithathwe. Uphando luye lwabonisa ukuba isicatshulwa singasifumana kubisi loluntu lwabahlengikazi.
> Imithombo:
> Ukumisela ulwazi. Zorvolex. Upapashwe ngoAgasti 2014.
> I-FDA iyavuma i-Zorvolex yoNyango lwe-Osteoarthritis Pain. HCPLive. Agasti 25, 2014.