Iinkqubo ezintathu eziyinhloko zesistim se-nervous system (central brain and spinal cord), inkqubo ye-nervous system (izitho kunye namalungu), kunye nenkqubo ye-nervous autonomic (inkqubo yokulawula, ukugcina i-homeostasis emzimbeni). Indima ye-lupus kwi-system ye-nervous system ihlala ingacacile.
Kule ngqungquthela, siza kugxininisa kwinkqubo yesistim ephakathi kunye nezinye iindlela i- lupus ichaphazela ngayo inkqubo.
I-Central Central yeNervous System
Imiphumo ye-lupus kwinkqubo ye-nervous central ibanzi. I-Lupus inokubangela ubuninzi beenkqubo zesisongomso seentambo, kubandakanywa, kodwa kungaphelelanga, ukungasebenzi, ukutshatyalaliswa, ukubetha, kunye neentloko. Ezi ngxaki zinxulumene ne-vasculopathy (isifo esithinta imithwalo yegazi), i-autoantibodies, isifo se-cardiovascular and acceleratory molecules. Izigulane zeLupus nazo zinokuvelisa inkqubo ye-nervous system ye-vasculitis.
I-vasculitis ye-nervous central (i-CNS vasculitis) ichanekile ukuvuvukala kwengqondo kunye nemithambo yegazi yomgogodla kwaye mhlawumbi iyinkxalabo enzulu kakhulu ehambisana ne-systemic lupus erythematosus (SLE). Ukubonakala kwayo njengesifo esiyintloko sisisiseko esingaphantsi kwesifo sayo sesibini, njengesi-SLE.
Iimpawu kunye neempawu zesistim se-central vasculitis ziquka amafiva aphezulu, ukuxhamla (ixesha elilodwa okanye eliqhubekayo), ingqondo yengqondo, ukuqina kwentamo, kunye neentloko ezinzima ezingaphenduliyo unyango oluqhelekileyo.
Ukuxubha kunye nemivimbo ingase ivele ngokuzimeleyo kwi-vasculitis kwaye ingadibana ne-autoantibodies eyandisa ingozi yokubetha.
I-CNS vasculitis kunzima ukuxilonga kwaye ngamanye amaxesha kuthathwa njengesifo sokuxilongwa esivela kumzamo weqela. Uninzi lweemvavanyo, ezifana ne-CT (i-computed tomography), i-MRIs (i-imagination magnontic resonance), kunye neesampuli zamanzi empompo zibonelela ngakumbi kunokuba zifumane ukuxilongwa.
Le nto ichazwe ngokubanzi, kodwa xa sele ifunyenwe, oogqirha banokunyanga i-CNS vasculitis eyiyo ngokudibanisa kwamanani aphezulu e- corticosteroids kunye ne-cyclophosphamide, enikwa kwisibhedlele.
Phantse i-10% yazo zonke izigulane ze-lupus zingahlangabezana nale fom ye-vasculitis kwaye yindlela ephela yenkqubo yesistim ephakathi kwenqanaba lase-American College of Rheumatology yokuchaza i-SLE.
Ukungasebenzi kweCognitive
Izigulane ze-Lupus zingathi zidideke, ngamanye amaxesha, zibe nzima ukuziveza ngokwazo, kwaye zifumane ukukhubazeka kwememori, zonke ezihambelana nezifo zabo. Ngokubambisana, le miqondiso kunye neempawu zibhalwe njengobunzima bokuqonda . Isizathu sokuba badibene ne-lupus asiyazi.
Iimpawu ezinxulumene nokungasebenzi komzimba zihlala zilawulwa ngamathambo okanye i-corticosteroids. Olunye unyango lwendlela yokuziphatha lunokubakho luncedo.
Intloko
Iintsholongwane ezichaphazelekayo i-lupus zifana ne-migraines ngamandla abo kwaye zihlala ziphathwa ngokufanayo. I-Corticosteroids inokukunceda.
Fibromyalgia
Kuqikelelwa ukuba malunga ne-20% yabantu abahluphekayo be- SLE nabo bane-fibromyalgia, i-disorder eyenza intlungu yesisu kunye nokukhathala kwiindawo ezithile zomzimba, njengentamo, amahlombe, umva, isango, iingalo kunye nemilenze.
Babizwa ngokuba "ngamanqaku eethenda" kuba banesithintelo kwisithintelo. Oku kuvame ukuphathwa ngamachiza enyango kunye nonyango, nangona iziphumo zentsholongwane zengxaki ziphathwa ngamanyathelo okuxhatshazwayo kunye nokucebisa.
Oko Ugqirha Ufuna Ukukwazi
Kubalulekile ukuvumela ugqirha wakho ukuba uyazi ukuba unobandezelekayo naziphi na iimpawu okanye iimpawu ezinokuthi zidibaniswe nenkqubo yesifo. Ugqirha wakho uya kufuna ukuqonda isizathu esona.
Unako ukuqhuba iimvavanyo eziliqela, kubandakanya ukuhlolwa ngokomzimba kunye nokuhlolwa kwebhubhoratri, okubandakanya umsebenzi wegazi kunye nokuhlaziywa kwegazi. Iimviwo ezichanekileyo zokumisela kunye nokufumana inkqubo ye-nervous involvement in lupus ziquka:
- Isilinganiselo sokuhlalisa, ukuhlolwa okungafunekiyo okuhlolisisa ngokuchanekileyo ukuba kungakanani ukuvuvukala emzimbeni.
- Uvavanyo lwe-ANA (i-anti-nuclear antibody), oluchaza i-autoantibodies ezihlasela izicubu zomzimba kunye neeseli.
- Uvavanyo lwe-Anti-DNA, oluqinisekisa ukuba kukho i-antibodies eziveliswa kwizinto eziphathekayo kwi-cell.
- Uvavanyo lwe-anti-ribosomal P.
- Ukuzalisa, uvavanyo lwegazi olulinganisa umsebenzi weeprotheni ezithile kwindawo ethile yamanzi egazini.
Ugqirha wakho unokukwazi ukuqhuba uchungechunge lweemvavanyo ze-neurological ezifana ne-CT, SPECT (i-photon enye ye-phosphate emission tomography) okanye i-MRI, i-electroencephalogram, umpompo womgcini (ukujonga iiseli, iiprotheni kunye ne-antineuronal antibodies), okanye i-PET (positron emission scanography).
Unyango
Iinkatho ezithile zonyango ziphawulwe phantsi kweentlobo ezingasentla, kodwa kufuneka kuqatshelwe ukuba impendulo kwonyango ngayinye iqhubela i-gamut ephawulekayo ukuya ekugqibeleni. Kodwa ininzi, ukubandakanyeka kwenkqubo ye-nervous is reversible.
Imithombo:
> Uhlelo lweNervous. Lupus Foundation yaseMelika. Ja nuwari 2008.
> Yintoni iVasculitis ?. I-Heart Heart, i-Lung ne-Blood Institute. Agasti 2006.
> Yintoni Okufuneka Uyazi Ngokwe-Central Nervous System ye-Vasculitis. Kliniki yaseCleveland. Isebe leRheumatic and Immunologic Diseases. Oktobha 2006.
> Iinkcukacha ezifutshane malunga neFibromyalgia. Isiko seSizwe seArthritis kunye neMisculoskeletal kunye Nezifo Zesikhumba.