Ukwazi iSitha Sakho
Umonakalo womlenze obangelwa zizifo zokuphefumula ngokuphindaphindiweyo yiyona nto ibangela ukufa kwabantu abane- cystic fibrosis . Ukukwazi ezinye zezifo onokujamelana nazo kunokukunceda ulungiselele imingeni ezayo kwaye ucwangcise iindlela zokunciphisa ingozi yakho. Ezi zinto zilandelayo azikho rhoqo kwiindawo eziphilileyo, kodwa zixinzeleleke kakhulu kubantu abaneCF.
Aspergillus
I-Aspergillus yi-fungus eyenzeka ngokuqhelekileyo kwimeko, ngoko kunzima ukuba akunakwenzeka ukuphepha ukudibana naye. Kubantu abaninzi, i- Aspergillus ayiyingozi kodwa i-15 ekhulwini yabantu abane-cystic fibrosis, ingakhokelela kwimeko esongela ubomi ebizwa ngokuba yi-aspergillosis (ABPA) ye-bronchopulmonary.
Kule meko, uya kuba ne- Aspergillus kwi-mucus emiphakeni yakho kodwa ayiyiyo ingenelo. Esikhundleni saloo nto, kubangela ukuphendulwa kwamagciwane okugqithiseleyo kunye nama-antibodies kunye namaseli omzimba, okwenza i-eosinophilic pneumonia. Iimpawu zibandakanya ukukhwehlela ngamanqatha angcolileyo okanye amanqatha kwi-sputum yakho. Uya kuba neempawu ezinjenge-asthma ezifana nokuvinjelwa kwesondo kunye nomoya. Kwiimeko ezinzima, unakho unomkhuhlane, intloko, kunye nokulahleka kwesidlo. Kufunyaniswa uvavanyo lwe- Skin prick test for Aspergillus antigen kunye novavanyo lwegazi lwe- Aspergillus precipitins kunye ne-IgE antibodies kunye ne-X-ray okanye CT.
Unyango lunomlomo we-prednisone njengoko i-corticosteroids ekhuselweyo ayisebenzi kakuhle kwi-ABPA. Ukuba i-ABPA iyaqhubeka, unokuphathwa ngophilisi olukhuselayo. Izigulana zilandelwa ngesifuba se-X-rays, iimvavanyo zomsebenzi wamapulmoni, kunye neemvavanyo zelabhu njengomonakalo wamaphaphu zingaqhubeka zikhona ngaphandle kweenguqu kwiimpawu. Kukho umngcipheko wokwanda ngokusisigxina kwe-airways ephakathi, eyaziwa ngokuba yi-bronchiectasis, kunye nokutshatyalaliswa kwemiphunga.
Pseudomonas aeruginosa
Ingaphezulu kwesiqingatha sabo bonke abantu abane-cystic fibrosis baya kulwa nosulelo lwemiphunga elibangelwa yi-bacteria Pseudomonas aeruginosa ngexesha elithile ebomini babo. Enyanisweni, yimizimba ebonakalayo ngokuqhelekileyo kwi-CF ehlobene nemiphunga yezifo zamaphaphu. Ngaloo ndlela, uP. aeruginosa nayo ibhaktheriya ejongene nokufa kwabantu abaninzi abaneCF.
I-P. aeruginosa ibhakteria eqhelekileyo ifumaneke kuyo yonke indawo emhlabeni, iinkomfa, imvula, kunye nezinye iindawo ezinomanzi, ngoko ayikwazi ukunqandwa. Kunzima ukulahla xa kuhlasela umzila wokuphefumula.
Ifom ye-tobramycin, ebizwa ngokuba yi-TOBI, isetyenziselwa ukunyanga izifo ezingapheliyo ze- Pseudomonas kubantu abane-cystic fibrosis. I-powder eyomileyo I-TOBI i-Podhaler iye yaphuhliswa.
Burkholderia cepacia
I-Burkholderia cepacia , eyayibizwa ngokuba yiPseudomonas cepacia , iyinto engabonakaliyo kodwa ebalulekileyo kubantu abane-cystic fibrosis. Nangona iimeko zakho ziyakuthanda ukuba awuze uhlangabezane neBurkholderia cepacia , kufuneka ube nolwazi oluyisiseko malunga nokuba yintoni na ukunciphisa ingozi yokuyifumana.
Nangona kusekusingqongileyo, iintlobo ezithintela abantu ngoku ziboniswa ukuba zisasazeka kumntu kumntu. Inokwenza i-colonize imiphunga kwaye ibangele intsholongwane eyenza ukuba ihlaziye ngokukhawuleza ukusebenza komphunga. Ingasasazeka kuwo wonke umzimba obangela i-cepacia syndrome ngokutshabalalisa ngokukhawuleza kwemiphunga. Oku kunokukhokelela ekufeni. Iphathwe ngonyango oludibeneyo njengoko lunokumelana nemithi eminingi yokulwa namachiza.
MRSA
I- Staphylococcus aureus engamelana ne-Methicillin (MRSA ), iba yinkxalabo eqhelekileyo kubantu abane-cystic fibrosis. I-MRSA ingafumaneka kwesikhumba, ngamanxeba, kumchamo, kunye nezinye iindawo zomzimba kodwa imiphunga yindawo eqhelekileyo yokusuleleka kwe-MRSA kulabo abaneCF.
UMasipala we-MRSA usasazeka ngokuqhagamshelana ngqo nangokungahambelani kunye kwaye unokufunyanwa kuluntu okanye esibhedlele. Ukusebenzisa ukulawula ukutheleleka kakuhle kunokunceda ukunciphisa umngcipheko.
> Imithombo:
> Gautam, V .; Singhal, L .; noRay, uP. " Burkholderia cepacia complex: Beyond pseudomonas kunye ne-acinetobacter." I-Ind J Med Microb. 2011; 29 (1): 4-12.
> Ortega VE. I-Bronchopulmonary Aspergillosis (ABPA). I-Merck Manual Professional Professional Version. http://www.merckmanuals.com/professional/pulmonary-disorders/asthma-and-related-disorders/allergic-bronchopulmonary-aspergillosis-abpa#.
> I-Ramphal R. Izifo ngenxa yeeNdawo zePseudomonas kunye neeNxulumene eziNxulumeneyo. Ku: Kasper D, Fauci A, Hauser S, uLongo D, Jameson J, Loscalzo J. eds. Iinqununu zeHarrison ze-Internal Medicine, 19e . New York, NY: McGraw-Hill; 2015.