Yintoni ebangela i-Graft vs Izifo zeHlabathi kwaye ingaba ikhuselwe?
Yiyiphi isifo se-graft versus host (GVHD), kutheni kwenzeka ntoni, njani kuphathwa ngayo, kwaye ingayinqandwa?
I-Graft vs.us Izifo eziHlabathi (iGVHD) - Inkcazo
Isifo se-graft versus host (GVHD) sisisiphumo esisecaleni somnxeba we- allogeneic okanye i-stem cell transplants . Nangona amathuba okuphuhlisa i-GVHD ahluka, ama-40% ukuya kuma-80% abemkeli be-transplant afumana i-GVHD ngenye indlela okanye enye.
I-GVHD idla ngokukhawuleza, kodwa ngezinye iinkqubo inokuba nzima ngokwaneleyo ukuba ibe yingozi yokuphila. Eli nqaku liza kukuthatha ngokubaluleka kwesi siphumo sokubaluleka okubalulekileyo kwaye kunokubangela ukunyuka.
Izizathu - Kutheni i-Graft Versus Infused Harm (GVHD) ivela?
Umnkantso okanye iiseli ezinamahlumela ezifakelwa kwisigulane ziqulethe iiseli zegazi zomnikeli. Olunye uhlobo lweseli yegazi olukhoyo kwiiseli zegazi ezinikelwe yiT cell (okanye i-T i-lymphocyte.) Iiseli ze-T zinesisindo ezinamandla kwi-immune system efuna abahlaseli njengabaktheriya kunye ne-virus kunye namanye amaseli angaphandle. Ingxaki ngokutshintshwa kukuba loo maseli e-donor ngoku aqonda iiseli kummkeli njengento yangaphandle. Ngako oko umnikeli (iiseli zengxube) ahlasele ummkeli (umphathi wokufakelwa.)
Ngaphambi kokuba kwenziwe ukufakelwa, abaxhasi kunye nabanikezeli be-transplant i-HLA ifanelana nokunciphisa amathuba okuhlaselwa, nangona ngaphandle kokuba umdlalo ufana (umzekelo, ukusuka kwimbini efanayo) kuhlala kudala ithuba lokuphuhlisa i-GVHD.
Ziziphi iiMpawu zoHlelo lweGraft Versus Host (GVHD)?
Iimpawu eziqhelekileyo ze-GVHDdepend nokuba ingaba yingozi (ekuqaleni) okanye ingapheliyo.
- I-GVHD eqhelekileyo - I-GVHD eqhelekileyo ivela kwiintsuku ezili-100 zokutshintshwa kwaye ngokuqhelekileyo iyakuthinta ulusu (ulwandle,) amathumbu, nesibindi. Abantu banokuba nama-rashes abaluleke kakhulu ezandleni zabo nasezintwini, kwaye iindawo zesikhumba zinokuthi zitshintshe. Ukubandakanywa kwamathumbu kungabangela i-nasusea, i-cramps yesisu, kunye nesifo sohudo, kanti ukubandakanyeka kwesibindi kuvame ukuphumela kwi-jaundice - ukuhlaziywa okwesibhakabhaka kwesikhumba.
- I-GVHD engapheliyo-GVHD engapheliyo ivela emva kweentsuku ezili-100 kwaye inokuxhamla okanye ingahambelani ne-GVHD enzima. Kuye kwenzeka ngokuqhelekileyo kubantu abaye bafumana impendulo enzima. I-GVHD engapheliyo ihlala ichaphazela iindawo ezininzi zomzimba. Ukongeza kokubandakanyeka kwesikhumba, amathumbu, nesibindi njengendlela yokuphendula ngokukhawuleza, i-GVHD engapheliyo ihlala iquka amehlo oomileyo okanye utshintsho lombono, intlungu kunye nokuqina kumalungu, ukuqina kwesikhumba kunye nokuxubha kunye nokuguqulwa, kunye nokukhathala, ubunzima beentlungu kunye nobuhlungu obungapheliyo . Izimpawu ezingapheliyo zinokuba nefuthe elide elide kumgangatho wobomi kunye nomgangatho wobomi.
Ngaba iGraft Versus Host (GVHD) ingazikhusela?
I-GVHD yimeko enokuba nzima kakhulu, kwaye impumelelo okanye ukungaphumeleli kokutshintshwa kuxhomekeke kuninzi ekukhuseleni okanye ukunciphisa imiphumo emibi yalo mqathango. Kukho iindlela ezininzi zokuba i-GVHD incitshiswe. Ezi ziquka ukulingana kwe-HLA ngokuchanekileyo , ukusebenzisa iziyobisi ukunciphisa i-GVHD, nokususa iiseli zeT kwigazi lomnikezeli. Ngenxa yezizathu ezithile, ke, ukususa iiseli ze-T kunokuba nefuthe elibi kwimpumelelo yokufakelwa kwezinye iindlela.
Ukulawulwa ngokunyameko kweempawu zokuqala ze-GVHD kunokuba luncedo, ngokunjalo ngokunyamekela ukukhanya kwelanga, njengoko kubonakala ngathi le nto ibangela ukunyuka kweGVHD.
I-Graft versus Host Disease (GVHD) ithathwa njani?
I-GVHD ayilula ukuyiphatha. Iquka uvavanyo kunye nokuguqulwa kweziyobisi ezinikezelwa rhoqo ukukhusela i-GVHD. Kwakhona kuquka ukuongeza izidakamizwa ezintsha, ngokukodwa i-steroids, ukuyeka umonakalo kwizitho zommkeli wokufakelwa. Ngamanye amaxesha, xa i-steroids ingonelanga ukulawula kakuhle imeko, ezinye iziyobisi zingadinga ukongezwa.
Imithombo:
Bayraktar, U., kunye noJ. Nates. Iziphumo zokunyamekela ezinzulu kwizigulane ze-hematopoietic stem cell transplantation. I-World Journal ye-Clinical Oncology . 2016. 7 (1): 98-105.
I-Chao, N. Ukubonakaliswa kwezonyango, ukuxilongwa, kunye nokufakwa kwezifo eziphambili. Updated 05/04/15. http://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-grading-of-acute-graft-versus-host-disease