Abantu ababalelwa kwizigidi ezili-16 bahlushwa yi-eye eye syndrome e-United States. Abasebenzi bezempilo bayalindela ukuba i- eye eye syndrome iya kukhula ngenxa yokuba abantu bethu begugile. Kwakhona, sonke sisebenzisa ikhomputha kwaye sininzi ngathi sibonakala sihamba ngeefowuni eziphathekayo, izixhobo zedijithali kunye neekhompyutha.
Yonke le mi sebenzi inxulumene neliso elomileyo.
Ukuqonda i-Dry Eye Syndrome
I-eye syndrome yamehlo yimeko apho amehlo akho angavelisi iinyembezi ezaneleyo zokugcoba nokunyusa inxalenye yangaphambili yeso. Iinyembezi zenziwa ngamakhulu eentlobo ezahlukeneyo zee-molecule eziquka i-lysozymes (iintsholongwane zendalo), iivithamini kunye neemaminerali, kunye ne-mucus, i-oyile kunye namanzi.
Ukuvelisa imveliso ngokukhawuleza kuncipha njengoko senzala. Xa sineminyaka engama-65, sinama-65 ekhulwini ngaphantsi kweendleko zokulila kunokuba senza kwi-18 kaninzi. Iimeko ezininzi ezizimeleyo zimehlo ezinomileyo njengengxenye yengxaki yabo. Bobabini izimo zonyango kunye namayeza athathwe ukuwaphatha angabangela isifo somlenze omile. Imimandla ethile, efana nemimoya yomoya okanye eyomileyo, inokunciphisa inani lezinyembezi okanye yenza iinyembezi ziphume ngokukhawuleza.
Umgangatho kunye nobungakanani
Nangona ubuninzi bezinyembezi kubalulekile, unokuba noomama obomileyo ukuba umgangatho wezinyembezi zakho awufanelekanga.
Kubalulekile ukuba nefilimu yokulila enempilo yokugcina imbonakalo ecacileyo. Ukuba neenyembezi neoli kakhulu okanye umqubu unobungozi nje ngokuba neqondo elinciphile lecandelo lemanzi yezinyembezi zakho.
Ezinye iinxalenye zezinyembezi zakho zinceda ukugcina ifilimu yakho yokulila. Uluhlu lweoli lwezinyembezi lunciphisa ukukhuphuka kwamanzi.
Ezinye iimeko ezenza ukungalingani kwinqwelo yeoli yezinyembezi i- blepharitis kunye ne- meibomian gland ukungasebenzi . Uluhlu lwe-muscus lunceda ukugcina iinyembezi zibopha phezulu kweso. Olunye uhlobo lwamehlo omile ngamanye amaxesha libhekiswa njengeliso elomileyo eliphumayo.
Njalo xa uqhafaza, ijwabu leso lihamba ngokuhamba kunye nentshukumo ephilileyo ekubhekeni kwempumlo yakho. Le ntshukumo ejikelezayo iqhubela phambili iinyembezi zakho ekhoneni liso lakho apho iindawo zokuhambisa amanzi, ezibizwa ngokuthi i- puncta , zinokukrazula iinyembezi zibe yimpumlo kunye nasemva emqaleni. Ngezinye iinyembezi ze-blink zisasazeka ngaphesheya kweso kwaye zihlambulule umphezulu we-cornea, isakhiwo esicacileyo se-dome-engxenyeni yangaphambili yelihlo.
Iimpawu zesifo somzimba esomileyo zivuthayo, zibetha, zibuhlungu obukhulu kwaye zimehlo ezikhathele. Abantu abaninzi abanobuhlungu bamehlo abomileyo bayakhalaza ngesimo esinjengesihlabathi esweni labo. Umbono uphinde uhlalutye.
Ukwelashwa Kwamehlo Omile
Ukunyangwa kwamehlo omile kuninzi ngokuxhomekeka kwimeko enzima. Uninzi unyango luqala ngezinye iinyembezi ezinokubakho. Iinyembezi zokwenza izinto zenzelwe ukuncedisa iinyembezi zendalo kunye nokunceda ekuphiliseni ubuso kweso. Ziyalelwe naphi na amaxesha athile ngosuku ngemini nganye.
Ngamhla, iinyembezi ezibonakalayo zifumaneka kwiintlobo ezahlukeneyo. Ezinye zilondolozo lwamahhala, ezinye zijolise ekunyuseni inxalenye yamanzi yezinyembezi, kwaye ezinye zihlose ukuzinzisa i-mucus kunye neoli yefestile yokulila. Ukutyelela ugqirha uya kugqiba ukuba uluphi uhlobo lwezinyembezi ezenziwayo.
Njengoko iimpawu zanda, i-gels kunye namafutha anqunywe. Iigels kunye namafutha athambisa ukusetyenziswa ngaphantsi ngenxa yeempembelelo zabo zecala. Nangona kunjalo, bazisa kakhulu uncedo kubantu abanomlingo omeleyo.
Unyango lwe-eye eye syndrome luquka iinkqubo ezinjenge-punct occlusion. Ukugqalwa kwamatyala yinkqubo apho izimpembelelo zesikhashana okanye ezisigxina zifakwe kwi-puncta, umsele wamanzi wokulila ukuze ugcine iinyembezi eziqhelekileyo.
Amaconsi esiso se-Steroid anqunywe kwiimeko ezinzima kakhulu kweso elomileyo.
Ngo-Oktobha 2003, i-Restasis yavunywa ukuba yonyango lwe-eye eye syndrome. Eli lixesha elivuyisayo kuba liyilisi-mvume yokuqala evunyiweyo ngokunyanga kwamehlo ename. I-Restasis ayiyiyo inyembezi, kodwa kunokuba ityhuse ekhuthaza ngokwenene imveliso yenkqantosi.
I-Cyclosporin A yikhemikhali e-Restasis yaye ithathwa njengesicatshulwa se-immunomodulatory. I-Immunomodulatory ithetha ukuba ichaphazela isistim somzimba sogonyamelo kwinqanaba elikhuthaza ukuveliswa kwemifanekiso yefilimu.
I-Restasis ijongayo iliso kwaye ithathwa kabini ngosuku, yonke imihla. I-Restasis isebenza kakuhle, kodwa ngokuthe rhoqo isigulane asiva okanye siyayiqonda inzuzo epheleleyo yokuthatha i-Restasis kwiinyanga ezintathu ukuya kwezi-4. Ngenxa yoko, ngamanye amaxesha kunzima ukuba oogqirha baxhamle kwizigulane ukuze baqhubeke bewuthatha. Ininzi yexesha, i-eye eye syndrome eyomileyo yimeko engapheliyo kwaye utshintsho lwangempela lwe-physiologic lwenzeka. Kuya kuthatha ixesha kunye naluphina uhlobo lwonyango ukubonisa ukuphucula kwangempela kuba ezo zinguqu zenyama zithatha ixesha elide ukuguqula.
I-Xiidra: Unyango olutsha
Kwiminyaka emininzi, i-Restasis yayisisigxina kuphela esilungiselelwe unyango lwamehlo omile. Nangona kunjalo, ngoJulayi 2016 isilwanyana sangena kwiimakethi zamehlo ezomileyo: i-Xiidra. I-Xiidra ngowokuqala kohlobo lwayo kwiqela elitsha leyeza elibizwa ngokuba ngumsebenzi we-lymphocyte-echaphazelekayo-anti-1 (LFA-1). Ngokutsho kovavanyo lwe-FDA, indlela yokwenziwa kwe-Xiidra yile ilandelayo.
I-Xiidra ngumsebenzi osebenzayo ngomlomo we-leukocyte ochaphazelekayo-1 (LFA-1) / intracellular adhesion molecule-1 (ICAM-1) inhibitor. I-LFA-1 yiprotheni yomhlaba weseli efunyenwe kwi-leukocytes kwaye ibingela ukusebenzisana kwe-LFA-1 kunye ne-cognate ligand intercellular adhesion molecule-1 (ICAM-1). I-ICAM-1 ingabonakaliswa ngokugqithiseleyo kwimizimba ekhulayo kunye ehlangeneyo kwisifo somlenze omile. Ukusebenzisana kwe-LFA-1 / ICAM-1 kunokuncedisa ekwakheni i-synapse ye-immunological eyenza ukusebenziswa kweT-cell nokufudukela ekujoliswe kuyo.
Ngoko, oko kuthetha ukuthini? Ngamanye amazwi, i-Xiidra ithatha iliso elomileyo ngokuphazamisa nokukhusela i-cascade evuthayo ejongene neempawu kunye nokutshintsha kwamehlo ezinxulumene nezifo zamehlo ezomileyo. Ukuvuvukala yinto eyenza ukuba iso lomsindo lube lusizi. Ukutshisa, ukugquma kunye nokubomvu kukubonakalisa ukuvuvukala kwaye oko kusenza sizive sibi. Kweminye uphando, iimpawu kunye neempawu ziphucula kwiintsuku ezimbini.
I-Xiidra iyisisombululo-esingasindisi esiluncedo kumabhodlela ngamanye, idibanisa ukuwa kwesibini kwimihlo kabini ngosuku. Indlela ye-Xiidra yesenzo ifana ne-Restasis kuba ithintela ukuphendula komzimba. Nangona kunjalo, i-Xiidra yiklasi ehluke ngokupheleleyo yeziyobisi. I-Restasis yinkqubo yokuxilongwa kwe-immunomodulatory medication eyenza ukunciphisa ukuvuvukala kwiingqungquthela zokulila, ukunceda ukukhusela umonakalo omkhulu. Kucatshangwa ukuba emva kokuthatha i-Restasis ixesha elide, ngaphezu kweenyanga ezintandathu, liyakwazi ukuphucula umkhiqizo weemfucuza kunye nokuphucula impilo yeeseli ze-goblet, ezibalulekileyo kwi-film stability. I-Xiidra ne-Restasis zombini zijolise kwi-cascade evuthayo. Nangona kunjalo, abazisebenzisani kunye nama-molecule athile ukuze kungabikho ubungqina obunokuthi bangasetyenziswa ngokudibeneyo.
Ngaba i-Xiidra FDA ivunyelwe?
I-Xiidra iye yavavanywa ngokupheleleyo kwaye ivunyiwe yi-FDA kwaye inokuphucula ngokuphawulekayo kuzo zombini iimpawu kunye nemiqondiso yesifo somlenze omile. Kwezinye iimeko zamehlo ezomileyo, i-punctate keratitis engapheliyo inokuphuhliswa kwi-surface corneal. I-Keratitis yukuvuvukala komhlaba ongabonakaliyo onokubonwa oogqirha ngokufaka idayi kwindawo.
Le nqubo ibizwa ngokuba yi-corneal staining. Ubuncwane bumele imeleko efile okanye eyenziwe yilelo ekhutshwe kwi-cornea. I-Xiidra yamkela isitampu se-FDA sokuvunywa kungekhona nje ukuphucula iimpawu kodwa ngokuqinisekileyo ukuphucula iimpawu zeso elomileyo, njenge-stainal staining. Enyanisweni, kwiingxelo ze-FDA, i-Xiidra ibonise ukuphucuka okukhulu kwiiveki ezimbini nje.
Ngubani Akufanele Asebenzise i-Xiidra?
I-Xiidra ayivunyelwanga ukusetyenziswa kunye ne-lens ukuze uxhumele iilensi zokudibanisa ngaphambi kokufaka kwaye ulinde imizuzu engama-15 ngaphambi kokuyibuyisela kwakhona. Imiphumo emibi ye-Xiidra ibandakanya ukutshisa, ukunambitheka kwentsimbi kunye nombono onqabileyo-ukuba unamava, qiniseka ukuthetha nodokotela wakho.
Izinto ezongeziweyo zokuqwalasela ngaphambi kokusebenzisa i-Xiidra
I-Xiidra ihlawula kwindawo ethile phakathi kwe-$ 400 ukuya kwii-450 kwizibonelelo ezingama-30 ngosuku, malunga neendleko ze-Restasis. Iindleko zibonakala zifana noko, kodwa i-Xiidra inemvume ye-FDA yokunyangwa kwamehlo omileyo kunye ne-Restasis inemvume yokwanda kweemveliso zentlungu, ngoko ke izinto ezinokukhuphisana zingadlala. Ugqirha wakho uyazi ukuba yeyiphi indlela engcono kwiimeko zakho, kodwa qalisa incoko uze ubuze isizathu sokuba umntu uphelele kunomnye.
> Umthombo:
> I-Xiidra (isisombululo se-lifitegrast ye-ophthalmic) 5% Ugqirha Ugqithisa i-Packet yolwazi, 2016 Shire US Inc, Lexington, MA 02421, Wonke amalungelo agcinwe. S24268 11/16