I-Rheumatoid Arthritis Isigulane kwiRituxan Study Study Developing Case of PML
Icala elibulalayo le-PML (i-letiencephalopathy multifocal leukoencephalopathy) ifunyenwe kwisifo sengqondo se- rheumatoid arthritis (RA) esithatha inxaxheba kwimeko yokwandisa ukukhusela i- Rituxan (rituximab). Ngenxa yoko, i-FDA kunye nomvelisi weziyobisi uye wakhupha isilumkiso kwaye iya kuhlaziya iRituxan imisela ulwazi ukufaka i-PML.
Yintoni i-PML?
I-PML yaziwa nangokuthi i-leukoencephalopathy ye-multifocal leukoencephalopathy.
Ngokutsho kweNational Institute of Neurological Disorders and Stroke, "i-progressive multifocal leukoencephalopathy (PML) ibangelwa ukusetyenziswa kwakhona kwegciwane eliqhelekileyo kwinkqubo yesantya yomntu omzimba onokukhubazeka. I-Polyomavirus JC (edlalwa ngokuba yi-JC virus) ithathwa Uninzi lwabantu kwaye alinangozi ngaphandle kwalabo abanokukhusela ukukhusela. "
Uyaziwa Ngakumbi nge-RA Umonde ophuhlisa i-PML?
I-RA isigulane saqala ukuvelisa intsholongwane ye-JC kunye ne-PML. Ukufa kwi-PML kwenzeka emva kweenyanga ezili-18 emva kokuba isiguli sifumane umthamo wokugqibela weRituxan kwisifundo sokwandisa ukhuseleko.
Isigulana se-RA saphinda sakha umdlavuza we-oropharyngeal ( umhlaza wesibeletho ) kwaye waphathwa nge-chemotherapy kunye neyezi-9 ezinyangeni ngaphambi kokuphuhlisa i-PML. Isigulane sinomlando wezobugqirha obunzima obunokuba negalelo ekuphuhlisweni kwe-PML. Ngaphandle kwe-RA, isigulane saba nesifo sikaSjogren kwaye singabonakali sisekela amazinga eC4.
Isigulane saphathwa nge-methotrexate, steroids, kunye ne-blocker ye-TNF ngaphambi kokuphathwa ngeRituxan. I-Methotrexate kunye ne-steroids nazo zisetyenzisiwe ngexesha kunye nangemva kwe-rituximab unyango.
Yintoni i-FDA eyenzayo ekuphenduleni imeko ye-PML?
I-FDA iphinda ibuye iphinde icwangcise imiyalelo kunye nokwazisa abaqeqeshi bezempilo kwileta kunye noluntu kwiwebhusayithi yalo malunga necala elibulalayo le-PML.
Yintoni ekufuneka i-RA izigulane zithathwe ngo-Rituxan?
Njengoko rhoqo, xubusha iingxaki zakho kunye nogqirha wakho. Iingcali zicebisa ukuba ukuba isigulane esiphathwe ngeRituxan sikhula iimpawu ze-neurologic - ukubonisana ne-neurologist, i-MRI yengqondo kunye nokugqithiswa kwe-lumbar kufuneka kuthathelwe ingqalelo. Izigulane eziphuhlisa i-PML kufuneka ziyeke i-Rituxan, mhlawumbi ziyeke okanye zinciphise ezinye i-immunosuppressants, ngelixa ziqwalasela unyango olutsha. Kodwa, akukho nonyango enokusombulula i-PML ukuba iyaqhubeka.
Imithombo:
I-FDA: I-Case of Death of Progressive Multifocal Leukoencephalopathy kuMguli ofumana iRituximab. News Guide Guide . Septemba 11, 2008.
FDA Medwatch. Ulwazi olubalulekileyo loKhuseleko ngokuphathelele kwi-Leukoencephalopathy ye-multifocal eqhubekayo kunye nokusetyenziswa kweRituxan. Septemba 11, 2008.