Ingaba i-Antibiotic Treatment iphumelele kwi-Rheumatoid Arthritis?
Imbali yoPhando lweNkcazo kunye neNyango
Ngaphandle kolunye unyango olwaziwayo lweentsholongwane ezingama-100 ze- arthritis , unyango kunye nokujamelana neempawu ezibuhlungu ziba yintloko yokukhathalela izigulane kunye noogqirha. Ngama-1930, imbangela yebhakteria ye- rheumatoid arthritis yaphandwa, kodwa uphando lwaluhlala ixesha elifutshane ngaphandle kweemeko ezahlukileyo zonyango osulelekileyo okanye olwahlukileyo .
Ngomnyaka we-1939, inkokheli yokuqala yokuqala ngokuphathelele isifo esasisifo esasifumene nesifo se-rheumatoid arthritis yavela xa i-mycoplasma, ibhakteria e-atypical-like-bacteria, yayingabikho kwimizimba yezigulane. Abaphandi babesele babonisa ukuba i-mycoplasmas ibangela i-arthritis kwiigundane, iinkozi, iinkukhu, iibhokhwe kunye neenkomo. Baye bafumanisa i-mycoplasmas kumaphecana e-genitourinary abantu, ngokukodwa amabhinqa.
Ngo-1949 kwi-International Congress kwi-Rheumatic Diseases ubuhlobo obukhoyo phakathi kwe-mycoplasmas kunye nezifo ezidibeneyo zabikwa. Emva kokufumana enye yezibonelelo zoPhando zeZiko lezeMpilo zikazwelonke (NIH) ngo-1950, uThomas McPherson Brown, MD kunye nabo basebenzisana neyunithi yocwaningo lwe-arthritis babika unyaka olandelayo ukuba indlela yokugula yesifo se-rheumatoid yayiyi-reaction immunologic ye-antigen kunye ne-antibody ( kunye ne-mycoplasma njenge-antigen engathandwayo) kunokuba luhlobo oluthatsayo nolutshintshisayo.
Ngo-1955, iyunithi yophando yabika ukuba i-mycoplasmas, ngokungafani ne-bacteria kunye neentsholongwane zingaphila kwiinkcubeko zeseli ezingenayo ngaphandle kokutshabalalisa iiseli zamathambo. Ukuqhubela phambili ukuxhasa i-mycoplasmas njenge-agent agent / antigen, ngowe-1964 iziganeko eziphezulu ze-mycoplasma antibodies egazini lezigulane ze-rheumatoid arthritis kunye nezigulane ze- lupus zifunyenwe, ezibonisa ukusuleleka kwangoku okanye kwangaphambili.
Kwakhona kwaziwa ukuba yi-4: 1 iziganeko eziphezulu ze-mycoplasma antibodies kumabhinqa abonisa ukuba ulungelelaniso kunye neziphumo eziphezulu ze-rheumatoid arthritis kuma-female.
Unyango lwe-antibiotics
Imizamo yokubonisa ukuphumelela kwonyango lweTetracycline yaqaliswa kwaye yaqala ingxelo ngaphezu kweminyaka engama-40 edlulileyo nguTomas McPherson Brown, MD. Kwiiveki ezimbini emva kokufa kukaBruwn ngo-1989, i-NIH yacela izicelo zezibonelelo zonyango ezilawulwa yi-tetracycline unyango lwe-rheumatoid arthritis ayifunayo. Iziphumo eziphambili zezilingo zeklinikhi, ezaziwa ngoku njengeMira okanye iMinocycline kwi-Arthritis yeRumatoid, zazithembisa kwaye i-NIH yacela izicelo zezibonelelo zezifundo ze-mycoplasma kunye nezinye izifo ezithathelwanayo njengezizathu zezifo ze-rheumatoid ngo-1993, kunye nesifundo sokuqhubela isifo se-antibiotic i-rheumatoid arthritis ngo-1994.
Isiphumo sesilingo se-MIRA sonyango sathi, "Izigulane ezithotyelwa kwi-RA ephantsi ukuya kwi-intanethi ngoku zikhethwa ngenye i-arhente yonyango. unyango lwe-rhumatoid.
"Kutheni iArthritis?"
Kuyo yonke le minyaka, iingcamango ezijolise kwi-mycoplasma njenge-arhente echaphazelekayo kunye ne-tetracycline njengoko unyango lwe-antibiotic olukhethiweyo luye lwaphazamiseka ngenxa yokungabikho kwemali eyaneleyo yophando olungakumbi kunye nezopolitiko.
"Kutheni iArthritis?" nguHarold W. Clark, Ph.D., omnye osebenza kunye noBrown, uvavanya izifo ze-rhumatoid, iminyaka emininzi yophando, ukukhangela unyango kunye nokukhungathekiswa kwabaphandi abanomdla we-anti-mycoplasma unyango owawunakucatshwa iminyaka engama-40 urhulumente kunye nemibutho eyahlukileyo ye-arthritis. UClak ukholelwa ukuba iinzame zaphazamiseka ngenxa yokuba unyango olukhuselekileyo, olulula luyisongela ukwakhiwa kwezonyango kuba izigulane ziza kufuna uncedo olunganyanga lwonyango.
Amagqirha amaninzi ahlala engathembeki kwaye awanakucetyisi unyango lwe-antibiotics kwizigulane zabo. I-Arthritis Foundation yayibonakala ingabonakaliyo nangona emva kokuba unyango lwe-antibiotics lubhekwa njengekhuselekile kwaye lusebenza.
Umqondisi wezobugcisa usiseko wathi akazange ajonge unyango njengento yokuphucula kunye nokufunda ngokuthe xaxa kunye nokusetyenziswa kwexesha elide le-minocycline.
Ngokwe-American College of Rheumatology, "i-Minocycline imiselwe izigulane ezineempawu zesifo se-rheumatoid esincinci. Ngamanye amaxesha kuhlanganiswe namanye amayeza ukunyanga izigulane ngeempawu eziqhubekayo zalolu hlobo lwe-arthritis."
Imithombo:
Kutheni iArthritis? Ukukhangela iCause kunye neCure ye-Rheumatoid Arthritis, nguHarold W. Clark, Ph.D., 1997
Cannon, uMichael. IMinocycline (iMinocin). Ikholeji yaseMerika yaseRheumatology. Ukuhlaziywa ngoMatshi 2015.