Izizathu zokufunda okungamanga kwiimvavanyo zeTroroid
Ngeemeko ezininzi kubandakanya isifo se-thyroid, sibheke kwixabiso lebhubhoratri ukunyanga unyango. Nangona kunjalo ixabiso lebhan linokuba yimpembelelo kunaliphi na isizathu sezizathu. Ngenxa yesifo se-thyroid, i- thyroid evuselela i-hormone (TSH) uvavanyo luye lwabizwa ngokuba yi-gold test test ukuhlola umsebenzi we-thyroid kodwa akusoloko ichanekile. Kwaye ukunyanga umzimba wakho ngokusekelwe ekufundeni kwamanga kunokubangela ukuba uzive kakuhle.
Amagciwane e-Heterophile acingelwa ukuba yisinye sezizathu zokufunda okungamanga kule mvavanyo. Yintoni omele uyayizi malunga neepalathisi zeebhati kunye neziphumo ezingavumelekanga?
Izizathu zeZiphumo ezingavumelekanga zoVavanyo kwiGenerari
Nangona sisoloko sijonga iimvavanyo zebhabhathatyala ngokungapheliyo zinikezela zona zinikezela ngeenombolo zeenjongo zekhonkrithi, akunjalo ngaso sonke isikhathi. Enyanisweni, ngokusekelwe kwintsingiselo yodwa mhlawumbi uye waba nesiphumo sokuvavanya okanye ezimbini ezingalunganga ngexesha lakho lobomi.
Ngeemvavanyo ze-thyroid, imbangela ebalulekileyo ngoku kuthiwa i-heterophile antibodies. Masiqale ngokuxoxa ngala mabhinqa, qwalasela ezinye izizathu zokuvavanya iimvavanyo ezingavumelekanga, uze uthethe ngezinto onokuzenza kunye noko kufuneka ukwazi ukuba ngummeli kwimpilo yakho.
I-Heterophile Antibodies kunye neziphumo zoVavanyo lweTyroid
Ngo-2011, intlanganiso yonyaka ye-endocrinologists yaziswa ukuba i-heterophile antibodies ingafaka ingozi yeziphumo ezingalunganga kwi-TSH yokuvavanya.
Ama-antibodies ase-Heterophile ayaziwa nangokuthiwa ngama-antibodies anesilwanyana kwaye aphuhliswa ngenxa yokuchasana nezilwanyana ezifumaneka kwizilwanyana kunye neyeza zokuphilisa.
Uphuhliso lwama-antibodies ase-heterophile luyaxhaphaka xa ufumene igazi, ugonywe, okanye ukuba uye wabonakala kwizilwanyana ezithile (kungekhona izilwanyana zasekhaya).
Akuqinisekanga ukuba i-heterophile antibodies eziqhelekileyo ziphi, kodwa uqikelelo luvela kwipesenti enye ukuya kuma-80 ekhulwini labantu. Ukungafani okubanzi kwintlupheko kuxhomekeke kwindlela ulwaphulo-mthetho oluchongwa ngayo.
Ukwanda Kamuva kwi-Antibodies yamaHeterophile
Ingqalelo kukuba ukubonakala kwama-heterophile antibodies kuye kwanda ngokuphawulekayo ngo-2010. Kwimeko echazwe kwintlanganiso, kwafunyanwa ukuba i-4.4 ekhulwini yamakhulu eesampuli evivinywe yathinteka ngama-antibodies. Eyona nkxalabo kukuba i-TSH engaqhelekanga ibangela ukuba kuqhutywe uvavanyo, kodwa ukuba uvavanyo aluyi kwenzeka njalo. Ngako oko, ubukho balezi zikhuhlane ziba nefuthe elikhulu.
Impembelelo ye-Heterophile Antibodies
Iimpembelelo ze-heterophile antibodies zinokubaluleka kakhulu kuba izigqibo zonyango zivame ukuqhutywa ngokusekelwe kwinqanaba le-TSH . Iimpawu ziyabonwa ngokuqinisekileyo, kodwa umgangatho wegolide uhlala uhlala kwiTSH. Oko kuthetha ukuthini ukuba abantu abaphila neengxaki ze-thyroid kufuneka baqaphele oku kubakho iziphumo ezingaqhelekanga.
Ngexesha lokumangalela i-Heterophile Antibodies
Ekubeni i-TSH yindlela esemgangathweni yegolide yokwenza utshintsho kumachiza e-thyroid, ungazi njani ukuba unayo i-heterophile antibodies ezichaphazela amanqanaba akho?
Kubonakala ngathi ukungafani phakathi kwe-TSH kunye ne-T4 yamahhala kuyimpawu. Nabani na onempawu ezingqinelaniyo neempawu zabo okanye ezingalindelekanga ngokusekelwe kwimbali yabo okanye idosa langoku lamachiza kufuneka babe nokuvavanya.
Ezinye izizathu ezinokuthi zifundwa ngamanga kwiimvavanyo zeTroroid
Ukongeza kwii-anti-antibodies ze-heterophile, kukho iindlela ezininzi zokuhlola iimvavanyo ezingabangela ukufundwa kwamanga ukusuka kwiziphene kwigazi lakho ukudweba ekuxubeni kwibhulebhu, kwiiphoso ekuguquleleni amanani. Siyazi ukuba iimpazamo zonyango ziqhelekileyo, kwaye kubangelwa isizathu esibalulekileyo sokugula kwanokufa. Kungenzeka ukuba izihloko ezihlaselayo zibiza iziphoso zonyango kwisithathu sesibangeleko sokufa ziphosakeleyo, kodwa kunikezelwa ukuba kwakucatshangelwa ukuba ibhendi ebomvu ibe ngummeli wakho kwaye uthethe ukuba kukho into engabonakali kulungile kuwe.
Ngokomzekelo, ukuba unempawu ze hyperthyroidism kwaye iimvavanyo zakho zebhabhi zibonisa ukuba u-hypothyroid kwaye ngokufanayo. Ngamanye amaxesha into enokuyenza yinto yokuphinda iqhube ukuhlolwa kwebhu, okanye ukucela uvavanyo oluthile oluya kubonisa ukungafani kwaye lubonise impazamo ekhoyo.
Ubunzima beNgxaki Unokuthi uhlaziywe
Nangona ukuqikelelwa kobukho be-heterophile antibodies kuthathwa njenganda kwanda, ingxaki inokuba yinto engathà sina njengoko kucinga kuqala. Ezinye iingcali zelabhoratri zithi amaninzi amaninzi aqulethe i-antibodies ekhuselekileyo eya kuphelisa ingxaki ye-TSH ephakamileyo. Kuze kubekho ukuvumelana okumele ukwazi?
Oku kuthetha ntoni kuwe
Ukwazi konke oku, unokwenza ntoni ukuba ube ngummeli wakho kwisifo se-thyroid? Ingaba uhambelana namanqindi a-heterophile okanye enye indlela yephulo lebhu, uthetha nodokotela wakho ukuba ungaziva kakuhle kakhulu. Ukuba uye waphathwa nge-hypothyroidism kwexesha elithile, unokuqonda indlela ovakalelwa ngayo ukuba iyeza lakho lonyango liphezulu okanye liphantsi. Ukuba ungeva kakuhle, yenza isigqibo.
Ukuba uphathwe nge-hypothyroidism kwaye ube ne-TSH ebuyela emva ephakamileyo (mhlawumbi ephezulu), mhlawumbi ukuba ugqirha wakho uza kukwandisa umthamo wakho we-hormone ye-thyroid. Ukuba amazinga akho aphakamileyo we-TSH, nangona kunjalo, ngenxa ye-antibodies ye-heterophile, ukunyuka kwezilingo kungabangela ukugqithiswa kwemithi kunye neyeza-ezibangelwa i-hyperthyroidism . Kwizihlandlo ezingaqhelekanga, oku kubangele i-thyrotoxicosis enzima ( isithwathwa se-thyroid ).
Ukuba uziva kakuhle kwi-dosage yakho, kwaye unomphumo ophezulu wokuvavanya kwe-TSH, kufuneka ucele ugqirha wakho ukuba asebenzise i-Free T4 kunye novavanyo lwe-Free T3 , ukuphinda ukhangele ukuba ingahambelana nezinga eliphakamileyo le-TSH.
Ukuba awunayo i-Thyroid Disease kwaye ube ne-TSH ephakamileyo
Ukuba awunakufumanisa ukuba unesifo se-thyroid kwaye une-TSH ephakamileyo, kuya kuba kuhle ukuba unayo i-hypothyroidism. Emva koko, isifo se-thyroid siqhelekile. Ngexesha elifanayo, unokuba ne-heterophile antibodies eyenza ukuphakama kwaye kungabonwa ngephutha.
Ukuba oku kwenzeka kuwe, cela udokotela wakho ukuba asebenze i-T4 yamahhala kwaye ukhulule iimvavanyo ze-T3 ukuqinisekisa ukuxilongwa kwe-hypothyroidism. Ngaphandle kwesi sitshixo, unokungafunyanwa ngephutha nge hypothyroidism kwaye uqale unyango olubangelwa unyango-olubangelwa i-hypothyroidism.
Ngaphantsi kwii-Antibodies ze-Heterophile kunye novavanyo lwe-TSH lobuxoki
Akucaci ukuba izifo eziphilileyo ze-heterophile zihlala kubemi bonke, kodwa xa zikhona zingabangela i-TSH yezinga eliphezulu (ngezinye iilingo kodwa zingabanye). Ukunyangwa ngokusekelwe kwinqanaba leTSH lodwa kunokubangela ukuba iyeza hyperthyroidism zonyango zonyango ziyabini zonyango zonyango kunye nezo zifunyanwe ngephutha nge-hypothyroidism esekelwe kuvavanyo.
Ukuba i-TSH yakho iphakanyisiwe kwaye unayo impawu ye-hypothyroidism (ukuba uziva ulungile) cela udokotela wakho ukuba ahlole i-T4 yamahhala kunye nenqanaba lamahhala le-T3 ukulungelelanisa amanani akho kwaye ujonge ukungahambisani.
> Imithombo:
> I-American Thyroid Association. Ngqungquthela yonyaka we-81. Abstract 103. 2011.
> Chin, K., kunye neY. Pin. I-Heterophile Antibody Interference ne-Assay Assay. Ngonyango lwangaphakathi . 2008. 47 (23): 2033-7.
> Lewndowski, K. Odd Iziphumo zemiSebenzi yeeTroid: Ukungafani nokungahambisani noMthetho. Uphando lwe-Thyroid . 2013. 36 (iSiza 2): A37.
> Ukuphela kwexesha, iS S. Fulminant Intsholongwane yeNgqumbo ehambelaniswe nokuchithwa kwe-Thyroid Storm ngenxa yama-Antibodies eHeterophile. Isifo sikashukela kunye ne-Endocrinology . 2015. 1:12.
> Srichomkwun, P., Scherberg, N., Jaksic, J., noS S. Refetoff. I-Dagnmatic Dilemma kwi-Thyroid Imisebenzi yokuvavanywa ngenxa ye-Hormone Autoantibodies. Iingxelo zeeKliniki ze-AACE . 2017. 3 (1): e22-e25.