I-Hashimoto's thyroiditis yinto yesifo se-thyroid esisodwa esikuyo, e-United States, eyona nto ibangelwa yi-hypothyroidism, i-thyroid engasebenzi.
Iimeko ezingaqhelekanga ezinxulumene neHashimoto's thyroiditis ngu-Hashimoto's encephalopathy (isicatshulwa njenge-HE). I-encephalopathy ye-encyphalopathy yinkinga ye-neuroendocrine eneendlela ezingaqondwa kakuhle ngabagqirha nabaphandi.
Kucingelwa ukuba njengesifo sikaHashimoto, ukunyuka kwe-Hashimoto kukuzimela ngokwemvelo, kwaye kubangelwa inkqubo yokuzivikela yintsholongwane kodwa ephosakeleyo ejolise kumalungu omzimba, izigulane kunye nezicubu. Kwimeko ye-Hashimoto ye-encephalopathy ijolongo yinjongo.
Qaphela: Ngenxa yokuba kungekhona zonke izigulane ezinobungqina bentsholongwane kaHashimoto, ezinye iingcali zibonisa ukuba le meko kufuneka iqeshwe ukuba isuse ikhonkco ku-Hashimoto, kwaye endaweni yoko kuthiwa "i- steroid-respondence-sensitive response that is in your brain ."
Siyazi ukuba kwi-encephalopathy yeHashimoto, amanqanaba aphakamileyo e-antithyroid antibodies (i-thyroid peroxidase antibodies, okanye i-TPO) ibonakala ihambelana nokuvuvukala kwengqondo engabonakalisa kwiimpawu ezahlukileyo.
I-Hashimoto ye-Encephalopathy ivela phi ixesha elide?
I-encephalopathy ye-Hashimoto ithathwa njengeyinqabileyo (kunezigulane eziliqela ezili-12 ezifunyenwe zizifo e-United States) kodwa kunokwenzeka ukuba kukho abantu abaninzi abangaboniyo abangafunyanwanga okanye abangafumani kakuhle.
Ngenxa yokuba ayengaziwa kakuhle kwaye iimpawu zayo ziyi-neurological, kubulula ukuphazamiseka okanye ukungaboni kakuhle kwaye izibonakaliso ze-Hashimoto ezinokubangela i-encephalopathy zihlala zikhokelela ekuphazamiseleni kweengxaki zegazi.
Umyinge weminyaka yokuqala kwe-Hashimoto's encephalopathy ineminyaka engama-47 ubudala. Uninzi lwezigulane ze-HE ziyabasetyhini.
UYE unokubonakalisa ebuntwaneni xa kusenokwenzeka ukuba angayihoywa. Iimpawu eziselula zibandakanya ukutshatyalaliswa, ukudideka, kunye neengcamango. Ukwehla kwesantya esikolweni kwimeko eqhelekileyo, kunye nokuncipha kwengqondo okuqhubekayo. Amanqanaba e-antibody we-thyroid kufuneka ahlolwe kuyo nayiphi na intsha eselula eneempawu, nangona ezinye iimvavanyo zesehlo ze-thyroid ziqhelekile.
Ezinye zeempawu eziqhelekileyo kubantu abadala abane-Hashimoto's encephalopathy ziquka ezi zilandelayo:
- ukudideka
- kwengqondo kunye nokuziphatha kakubi
- ukuthuthumela
- ingxaki kunye neengxaki zokukhumbula
- i-spasms kunye ne-jerks kwiimisipha ezibizwa ngokuba yi-myoclonus
- ukungabikho koqhagamshelwano
- intloko
- ukukhubazeka ngokwengxenye
- iingxaki zokuthetha
- utshintsho lwabantu.
- ulwalamano.
- ukuziphatha okubi.
- ingxaki kunye neengxaki zokukhumbula.
- ukuxhamla
- ukulala okungavumelekanga
UTHIXA uqhubela phambili ngeendlela ezimbini: mhlawumbi njengesihlasela esichukumisayo, esifana nesigxina okanye ukuhlutha; okanye ngokuqhubela phambili kwintsholongwane, okanye nakwi-coma. Ngamanye amaxesha, izigulane zifunyaniswa ngephutha njengokuba zine-stroke, isifo se-Creutzfeldt-Jakob, isifo sengqondo sokugula okanye isifo se-Alzheimer.
Okwangoku, akukho vavanyo olucacileyo lwe-Hashimoto's encephalopathy. Nangona i-antibodies ye-thyroid ingaba phezulu, ingabikho.
Ngokufanayo, amazinga e-TSH anokukhathazeka okanye anokungaqhelekanga. Unyango ngeyeza le-hormone ye-substituted medication ayicombululi HE.
Ufunyaniswa ukuba ulawulwa kwezinye izizathu zeempawu.
Unyango lwe-Hashimoto's Encephalopathy
Ulwaphulo oluphambili lwe-Hashimoto's encephalopathy liyilwayo ye-corticosteroid drugs, njenge-prednisone. Izigulane ezininzi ziphendula ngokuphawulekayo kunyango lweziyobisi, kunye nexesha eliqhelekileyo lokunyanga elinesibini kwiiveki ezintandathu. Njengazo zonke izifo ezixhamla ngokuzenzekelayo, INYE ayithathwa njengeyonyango, kodwa kunokuba ithathwe. Emva kokuqala unyango, le ngxaki ihlala ixolelwa.
Ezinye izigulane ziyakwazi ukuyeka unyango lweziyobisi iminyaka emininzi, nangona kukho umngcipheko wokuphindaphinda kwakhona.
Ukongeza kwonyango le-steroid, ezinye iindlela zokwelapha ezifana ne-immunoglobulin kunye ne-plasma exchange exchange are considered options.
Nangona iyingqayizivele, i-encephalopathy ye-Hashimoto ingaba yimbangela yokudandatheka, ukutshatyalaliswa kancinci, okanye ukuxhalabisa. Kuze kube yilapho iimeko zizibonakaliswa zizibonakaliso ezinzulu okanye ezingaphendulanga iimpawu ze-neuropsychiatric, ukuba oogqirha abaninzi bajonga imiba ye-thyroid, iigununu, okanye imbali yentsapho yokukhubazeka komzimba.
Izigulane ezinamava kaHashimoto zijongene nomngeni wokuxilonga kunye nezifo ezinokukhubaza. Ngenhlanhla, abaninzi abantu baphendule unyango olufumanekayo. Ukuba unobungqina obunomdla obunokwenjenjalo, ugqirha awukwazi ukuchaza, qiniseka ukuba ubhekisele kwimbali yakho okanye yentsapho yeHashimoto's thyroiditis okanye ezinye iimeko ze-thyroid.
> Imithombo:
> I-Carbone A, kunye. al. "I-Hashimoto's encephalopathy (HE): ngaphantsi kwe-diagnostic-mediation-mediation." Endocrine. 2016 Nov; 54 (2): 572-573.
> Kaczmarczyk A, et al. "U-Hashimoto u-encephalopathy - ukungabonakali kwengqondo ngokuthe tye." I-Wiad Lek. 2016; 69 (6): 768-772.
> ULarent C et al. I-steroid-responsive encephalopathy ehambelana ne-autoimmune thyroiditis (SREAT): Impawu, unyango kunye nesiphumo kwiimeko ezingama-251 ezincwadi. " U-Autoimmun u-Revised 2016 Dec; 15 (12): 1129-1133. i-doi: 10.1016 / j.autrev.2016.09.008. Epub 2016 Sep 15.
> Litmeier S, et al. "I-serum yokuqala ye-serum ye-peroxidase antibodies kunye neziphumo zexesha elide kwi-SREAT." Acta Neurol Scand. Ngo-2016 Dec; 134 (6): 452-457. i-doi: 10.1111 / ane.12556.
PMID: 26757046