Ezi Antibodies ziyakuthi Zithintele, kodwa aziyikunyanzelisa iHormone Replacement
Ama-antibodies ngamaprotheni aveliswa ngumzimba wakho ophendula okanye azame ukutshabalalisa ama-antigens, ezizinto ezifana ne-virus kunye ne-bhakteria, ukuba umzimba uchonga nje.
Kwezinye iimeko, umzimba wakho uchonga ngokugqithiseleyo izigulane, izicubu kunye nezitho zangaphandle. Olu hlobo lokusabela luphawu lwesifo sokuzimela , kwaye ezi zikhusela, ezenza ukuhlaselwa okungafanelekanga kumzimba womntu, zibizwa ngokuba ngama-auto-immune antibodies.
Enye iklasi ye-antibodies ye-auto-immune isifo se -peroxidase (TPO) , kunye nobukho babo ("ukuzithemba") kukhombisa ukuba kukho isifo se-thyroid esisodwa, ngokuqhelekileyo iHashimoto's thyroiditis.
Ukuqonda uHashimoto's Thyroiditis
KwiHashimoto's thyroiditis, iintsholongwane ze-TPO zihlasela i-thyroid gland.
Ngokuhamba kwexesha, i-TPO antibodies ibangela ukuvuvukala kwaye ekugqibeleni inokutshabalalisa yonke into okanye inxalenye ye-thyroid gland. Njengoko i-thyroid iyakwazi ukuvelisa i-hormone ye-thyroid, ungase ube yintsholongwane. I-antibodies yeHashimoto inokubangela ukuba i-thyroid ibe ne-nodules, okanye ikhuliswe, eyaziwa njenge-goiter.
Nangona kunjalo, kunokuthatha ixesha lokuba umonakalo owonakalisayo kwi-thyroid yakho ibonakaliswe kwizinga lakho lokuhlola i-hormone ye-thyroid (TSH). Akuqhelekanga, eqinisweni, ukuba ne-TBO ezinokuthi zenze iinyanga ezinomnyaka okanye i-nyaka ngaphambi kokuba i-TSH yakho iphakame kwizinga apho ufumanisa khona nge-hypothyroidism.
Kubalulekile ukukhankanya, ngokunjalo, ukuba abanye abantu abazange bathuthuke ekubeni yi-hypothyroid, nangona benama-TB anesifo esihle.
I-TPO Antibodies, i-TSH ejwayelekile: Ngaba i-Treatment iqinisekisiwe?
Ngokuqhelekileyo, ukuba isiphumo sakho sovavanyo lwe-TSH siqhelekile (phakathi kwee-0.4 no-4.5 million iiyunithi zamazwe ngamazwe ngeli litre, okanye i-MU / L), unyango (kunye ne-hormone ye-hormone substitution drug) alunyanzelwanga, nangona i-TPO i-antibodies is positive.
Nangona kunjalo, ukuba i-TSH yakho iphakanyiswe ngokunyanisekileyo (masithi ukuhamba nge-6.0mU / L) kwaye i-thyroxine yakho (T4) i-hormone iyaqhelekileyo, "ukuzithoba" kwe-antibodies ze-TPO kunokugqirha ugqirha wakho ekuqaliseni unyango lwe-hormone ye-thyroid. Oku kungenxa yokuba unyango olusenokuba lunokuthintela ukuqhubela phambili kwale nto kuthiwa yi-hyplinroidism e-subclinical kwi-overt hypothyroidism.
Ugqirha wakho unokugqithisa ngakumbi ukunyanga i-hyplinroidism yakho encinci xa unempawu ezifana nokukhathala, ukuzithemba, okanye ukuxinezeleka, okanye unesinye isifo sokuzimela, umzekelo, isifo se-celiac.
Ubudala buya kudlala indima kwisigqibo sakho sobugqirha. Ngokuqhelekileyo, kukho umda ophezulu wokuqalisa imithi ye-hormone ye-thyroid endaweni yokudala kubantu abadala, kuba i-TSH yabo yesiseko isemgangathweni ophezulu.
ILizwi
Umgca olapha apha kukuba ama-antibodies e-thyroid aphilileyo abonisa inkqubo yokuzimela; Nangona kunjalo, bayisitye nje se-pie ye-thyroid kwaye abaqhelekanga ukuba ngaba awuyidingi unyango lwe-hormone ye-thyroid. Esikhundleni saloo nto, zinokukuchaphazela kunye nesigqibo sakho soogqirha, phakathi kwezinye izinto ezifana nobudala bakho, imbali yentsapho kunye neempawu.
Ngokubanzi kukulungele ukuthetha nodokotela wakho malunga neziphumo zeebhan ekhethekileyo kunye neempawu.
Ngale ndlela unokuqinisekisa ukuba ulungiselele i-thyroid yakho kunye nempilo yonke.
> Imithombo:
> Braverman, L, Cooper D. Werner & Ingbar's The Thyroid, 10 Edition. WLL / Wolters Kluwer; 2012.
> Davies TF. I-Pathogenesis yeHashimoto's thyroiditis (i-autoimmune thyroiditis engapheliyo). Ross DS, ed. Isemgangathweno. Waltham, MA: UpToDate Inc.
> Garber, J, Cobin, R, Gharib, H, kunye. al. "Izikhokelo zeCliniki zoLwazi lwe-Hypothyroidism kubantu abadala: I-Cosponsored yi-American Association of Clinical Endocrinologists kunye ne-American Thyroid Association." I-Endocrine Practice. I-Vol 18 No. 6 uNovemba / Disemba 2012.
> Jonklaas J et al. Izikhokelo zoLonyango lwe-Hypothyroidism: Lulungiswe nguMbutho we-American Thyroid Association Task Force kwi-Hormone Replacement. Thyroid . Ngomhla ka-1 ku-1: 1 (24): 1670-1751.
> Kent, uAthol. "Iingqungquthela ze-Thyroid ezinxulumene nokuHlaliswa kweNdlu kunye nokuQala kwangaphambi kokuzalwa." Iingxelo kwi-Obstetrics and Gynecology 4.3-4 (2011): 128-129. 2011.