Ukusetyenziswa kwama-antiplatelet agents ezifana ne-aspirin okanye i-clopidogrel (i-Plavix) yindlela efanelekileyo yokukhusela isithintelo . Ngamanye amaxesha, xa abantu behlushwa i-aspirin ngelixa besithatha i-aspirin rhoqo, babonwa "ukungaphumeleli kwe-aspirin", kwaye abanye oogqirha bathi izigulane kufuneka zongeze i-agent ye-antiplatelet yesibini kwi-regimen ukwenzela ukukhusela imivimbo eminye.
Kodwa ubungqina bokuba yinto enengqiqo yokwenzayo ayinanto, kwaye ukwenza oku, kwindlela yokujonga uluntu, kunokuthi kubangele ubungozi ngaphezu kokulungileyo.
Ubuncinane oku kuhlaziywa kwangoko kwincwadi kwimiba yokuphuma kwegazi xa i-aspirin kunye nezinye i-antithrombotic ezisetyenziswayo kunye kunye nokukhuselwa kwe-stroke prevention kubonakala ngathi. Uphononongo lubonisa umngcipheko ophezulu kakhulu wokuphuma kwegazi xa i-aspirin isetyenziselwa ukudibanisa ne-clopidogrel, okanye i- coumadin . Amanani athile egaziweyo anikwe ingxelo anjengale ndlela: 4.8% nge-aspirin yedwa, 2.9% kunye ne-clopidogrel yedwa, 3.6% kunye ne-aspirin kunye ne-Aggrenox, kodwa i-10.1% i-aspirin kunye ne-clopidogrel, kunye no-16.8% kunye ne-aspirin kunye ne-coumadin.
Ukuphuma kwegazi okukhulu kwenzeka kwi-rate ye-1% ne-aspirin yedwa, i-0.85% nge-clopidogrel, kodwa i-1.7% ne-aspirin kunye ne-clopidogrel, kunye no-2.5% kunye ne-aspirin kunye ne-coumadin. Kwaye ngokudabukisayo oku kuhamba ngaphandle kokunye ukukhuselwa kwesifo xa i- aspirin kunye ne-Plavix zisetyenziswa kunye.
Ezi manani zibhekiselele kwaye zifanele ziqwalaselwe ngamandla ngaphambi kokuba i-aspirin kunye ne-clopidogrel (Plavix) zisetyenziselwa ukukhuselwa kwesibini.
Okokuthi, i-aspirin kunye ne-Plavix esebenzisene kunye kunokunceda ukukhusela imivimbo, njengoko kuboniswe ngophando olupapashwe kwi-New England Journal of Medicine apho ukuhlanganiswa kwe-aspirin kunye ne-clopidogrel kunciphise umngcipheko wokubetha kokuqala kubantu abane-fibrillation ye-atrial abangakwazi thabatha i-coumadin ngezizathu ezahlukahlukeneyo.
Nangona umngcipheko wokuphuma kwamanzi uphinde wanda kakhulu kuloo manani xa kuthelekiswa nalawo athabatha i-aspirin yedwa, iinzuzo zokudibanisa i-aspirin kunye ne-clopidogrel zingaphaya kweengozi.